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Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial

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Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial. / Meyer, Kristina; Hindi Attar, Catherine; Fiebig, Jana; Stamm, Thomas; Bassett, Tyler R; Bauer, Michael; Dannlowski, Udo; Ethofer, Thomas; Falkenberg, Irina; Jansen, Andreas; Juckel, Georg; Kircher, Tilo; Mulert, Christoph; Leicht, Gregor; Rau, Anne; Rauh, Jonas; Ritter, Dirk; Ritter, Philipp; Trost, Sarah; Vogelbacher, Christoph; Walter, Henrik; Wolter, Sarah; Hautzinger, Martin; Bermpohl, Felix.

In: BIOL PSYCHIAT-COGN N, Vol. 8, No. 7, 07.2023, p. 750-759.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meyer, K, Hindi Attar, C, Fiebig, J, Stamm, T, Bassett, TR, Bauer, M, Dannlowski, U, Ethofer, T, Falkenberg, I, Jansen, A, Juckel, G, Kircher, T, Mulert, C, Leicht, G, Rau, A, Rauh, J, Ritter, D, Ritter, P, Trost, S, Vogelbacher, C, Walter, H, Wolter, S, Hautzinger, M & Bermpohl, F 2023, 'Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial', BIOL PSYCHIAT-COGN N, vol. 8, no. 7, pp. 750-759. https://doi.org/10.1016/j.bpsc.2023.02.008

APA

Meyer, K., Hindi Attar, C., Fiebig, J., Stamm, T., Bassett, T. R., Bauer, M., Dannlowski, U., Ethofer, T., Falkenberg, I., Jansen, A., Juckel, G., Kircher, T., Mulert, C., Leicht, G., Rau, A., Rauh, J., Ritter, D., Ritter, P., Trost, S., ... Bermpohl, F. (2023). Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial. BIOL PSYCHIAT-COGN N, 8(7), 750-759. https://doi.org/10.1016/j.bpsc.2023.02.008

Vancouver

Meyer K, Hindi Attar C, Fiebig J, Stamm T, Bassett TR, Bauer M et al. Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial. BIOL PSYCHIAT-COGN N. 2023 Jul;8(7):750-759. https://doi.org/10.1016/j.bpsc.2023.02.008

Bibtex

@article{a39d591709ff44d0829013a4e9d2c446,
title = "Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial",
abstract = "BACKGROUND: In bipolar disorder (BD), the alternation of extreme mood states indicates deficits in emotion processing, accompanied by aberrant neural function of the emotion network. The present study investigated the effects of an emotion-centered psychotherapeutic intervention on amygdala responsivity and connectivity during emotional face processing in BD.METHODS: In a randomized controlled trial within the multicentric BipoLife project, euthymic patients with BD received one of two interventions over 6 months: an unstructured, emotion-focused intervention (FEST), where patients were guided to adequately perceive and label their emotions (n = 28), or a specific, structured, cognitive behavioral intervention (SEKT) (n = 31). Before and after interventions, functional magnetic resonance imaging was conducted while patients completed an emotional face-matching paradigm (final functional magnetic resonance imaging sample of patients completing both measurements: SEKT, n = 17; FEST, n = 17). Healthy control subjects (n = 32) were scanned twice after the same interval without receiving any intervention. Given the focus of FEST on emotion processing, we expected FEST to strengthen amygdala activation and connectivity.RESULTS: Clinically, both interventions stabilized patients' euthymic states in terms of affective symptoms. At the neural level, FEST versus SEKT increased amygdala activation and amygdala-insula connectivity at postintervention relative to preintervention time point. In FEST, the increase in amygdala activation was associated with fewer depressive symptoms (r = 0.72) 6 months after intervention.CONCLUSIONS: Enhanced activation and functional connectivity of the amygdala after FEST versus SEKT may represent a neural marker of improved emotion processing, supporting the FEST intervention as an effective tool in relapse prevention in patients with BD.",
keywords = "Humans, Bipolar Disorder, Brain Mapping, Neural Pathways, Amygdala, Emotions/physiology, Psychotherapy",
author = "Kristina Meyer and {Hindi Attar}, Catherine and Jana Fiebig and Thomas Stamm and Bassett, {Tyler R} and Michael Bauer and Udo Dannlowski and Thomas Ethofer and Irina Falkenberg and Andreas Jansen and Georg Juckel and Tilo Kircher and Christoph Mulert and Gregor Leicht and Anne Rau and Jonas Rauh and Dirk Ritter and Philipp Ritter and Sarah Trost and Christoph Vogelbacher and Henrik Walter and Sarah Wolter and Martin Hautzinger and Felix Bermpohl",
note = "Copyright {\textcopyright} 2023. Published by Elsevier Inc.",
year = "2023",
month = jul,
doi = "10.1016/j.bpsc.2023.02.008",
language = "English",
volume = "8",
pages = "750--759",
journal = "BIOL PSYCHIAT-COGN N",
issn = "2451-9022",
publisher = "Elsevier Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial

AU - Meyer, Kristina

AU - Hindi Attar, Catherine

AU - Fiebig, Jana

AU - Stamm, Thomas

AU - Bassett, Tyler R

AU - Bauer, Michael

AU - Dannlowski, Udo

AU - Ethofer, Thomas

AU - Falkenberg, Irina

AU - Jansen, Andreas

AU - Juckel, Georg

AU - Kircher, Tilo

AU - Mulert, Christoph

AU - Leicht, Gregor

AU - Rau, Anne

AU - Rauh, Jonas

AU - Ritter, Dirk

AU - Ritter, Philipp

AU - Trost, Sarah

AU - Vogelbacher, Christoph

AU - Walter, Henrik

AU - Wolter, Sarah

AU - Hautzinger, Martin

AU - Bermpohl, Felix

N1 - Copyright © 2023. Published by Elsevier Inc.

PY - 2023/7

Y1 - 2023/7

N2 - BACKGROUND: In bipolar disorder (BD), the alternation of extreme mood states indicates deficits in emotion processing, accompanied by aberrant neural function of the emotion network. The present study investigated the effects of an emotion-centered psychotherapeutic intervention on amygdala responsivity and connectivity during emotional face processing in BD.METHODS: In a randomized controlled trial within the multicentric BipoLife project, euthymic patients with BD received one of two interventions over 6 months: an unstructured, emotion-focused intervention (FEST), where patients were guided to adequately perceive and label their emotions (n = 28), or a specific, structured, cognitive behavioral intervention (SEKT) (n = 31). Before and after interventions, functional magnetic resonance imaging was conducted while patients completed an emotional face-matching paradigm (final functional magnetic resonance imaging sample of patients completing both measurements: SEKT, n = 17; FEST, n = 17). Healthy control subjects (n = 32) were scanned twice after the same interval without receiving any intervention. Given the focus of FEST on emotion processing, we expected FEST to strengthen amygdala activation and connectivity.RESULTS: Clinically, both interventions stabilized patients' euthymic states in terms of affective symptoms. At the neural level, FEST versus SEKT increased amygdala activation and amygdala-insula connectivity at postintervention relative to preintervention time point. In FEST, the increase in amygdala activation was associated with fewer depressive symptoms (r = 0.72) 6 months after intervention.CONCLUSIONS: Enhanced activation and functional connectivity of the amygdala after FEST versus SEKT may represent a neural marker of improved emotion processing, supporting the FEST intervention as an effective tool in relapse prevention in patients with BD.

AB - BACKGROUND: In bipolar disorder (BD), the alternation of extreme mood states indicates deficits in emotion processing, accompanied by aberrant neural function of the emotion network. The present study investigated the effects of an emotion-centered psychotherapeutic intervention on amygdala responsivity and connectivity during emotional face processing in BD.METHODS: In a randomized controlled trial within the multicentric BipoLife project, euthymic patients with BD received one of two interventions over 6 months: an unstructured, emotion-focused intervention (FEST), where patients were guided to adequately perceive and label their emotions (n = 28), or a specific, structured, cognitive behavioral intervention (SEKT) (n = 31). Before and after interventions, functional magnetic resonance imaging was conducted while patients completed an emotional face-matching paradigm (final functional magnetic resonance imaging sample of patients completing both measurements: SEKT, n = 17; FEST, n = 17). Healthy control subjects (n = 32) were scanned twice after the same interval without receiving any intervention. Given the focus of FEST on emotion processing, we expected FEST to strengthen amygdala activation and connectivity.RESULTS: Clinically, both interventions stabilized patients' euthymic states in terms of affective symptoms. At the neural level, FEST versus SEKT increased amygdala activation and amygdala-insula connectivity at postintervention relative to preintervention time point. In FEST, the increase in amygdala activation was associated with fewer depressive symptoms (r = 0.72) 6 months after intervention.CONCLUSIONS: Enhanced activation and functional connectivity of the amygdala after FEST versus SEKT may represent a neural marker of improved emotion processing, supporting the FEST intervention as an effective tool in relapse prevention in patients with BD.

KW - Humans

KW - Bipolar Disorder

KW - Brain Mapping

KW - Neural Pathways

KW - Amygdala

KW - Emotions/physiology

KW - Psychotherapy

U2 - 10.1016/j.bpsc.2023.02.008

DO - 10.1016/j.bpsc.2023.02.008

M3 - SCORING: Journal article

C2 - 36898634

VL - 8

SP - 750

EP - 759

JO - BIOL PSYCHIAT-COGN N

JF - BIOL PSYCHIAT-COGN N

SN - 2451-9022

IS - 7

ER -