Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial
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Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial. / Meyer, Kristina; Hindi Attar, Catherine; Fiebig, Jana; Stamm, Thomas; Bassett, Tyler R; Bauer, Michael; Dannlowski, Udo; Ethofer, Thomas; Falkenberg, Irina; Jansen, Andreas; Juckel, Georg; Kircher, Tilo; Mulert, Christoph; Leicht, Gregor; Rau, Anne; Rauh, Jonas; Ritter, Dirk; Ritter, Philipp; Trost, Sarah; Vogelbacher, Christoph; Walter, Henrik; Wolter, Sarah; Hautzinger, Martin; Bermpohl, Felix.
in: BIOL PSYCHIAT-COGN N, Jahrgang 8, Nr. 7, 07.2023, S. 750-759.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Daring to Feel: Emotion-Focused Psychotherapy Increases Amygdala Activation and Connectivity in Euthymic Bipolar Disorder-A Randomized Controlled Trial
AU - Meyer, Kristina
AU - Hindi Attar, Catherine
AU - Fiebig, Jana
AU - Stamm, Thomas
AU - Bassett, Tyler R
AU - Bauer, Michael
AU - Dannlowski, Udo
AU - Ethofer, Thomas
AU - Falkenberg, Irina
AU - Jansen, Andreas
AU - Juckel, Georg
AU - Kircher, Tilo
AU - Mulert, Christoph
AU - Leicht, Gregor
AU - Rau, Anne
AU - Rauh, Jonas
AU - Ritter, Dirk
AU - Ritter, Philipp
AU - Trost, Sarah
AU - Vogelbacher, Christoph
AU - Walter, Henrik
AU - Wolter, Sarah
AU - Hautzinger, Martin
AU - Bermpohl, Felix
N1 - Copyright © 2023. Published by Elsevier Inc.
PY - 2023/7
Y1 - 2023/7
N2 - BACKGROUND: In bipolar disorder (BD), the alternation of extreme mood states indicates deficits in emotion processing, accompanied by aberrant neural function of the emotion network. The present study investigated the effects of an emotion-centered psychotherapeutic intervention on amygdala responsivity and connectivity during emotional face processing in BD.METHODS: In a randomized controlled trial within the multicentric BipoLife project, euthymic patients with BD received one of two interventions over 6 months: an unstructured, emotion-focused intervention (FEST), where patients were guided to adequately perceive and label their emotions (n = 28), or a specific, structured, cognitive behavioral intervention (SEKT) (n = 31). Before and after interventions, functional magnetic resonance imaging was conducted while patients completed an emotional face-matching paradigm (final functional magnetic resonance imaging sample of patients completing both measurements: SEKT, n = 17; FEST, n = 17). Healthy control subjects (n = 32) were scanned twice after the same interval without receiving any intervention. Given the focus of FEST on emotion processing, we expected FEST to strengthen amygdala activation and connectivity.RESULTS: Clinically, both interventions stabilized patients' euthymic states in terms of affective symptoms. At the neural level, FEST versus SEKT increased amygdala activation and amygdala-insula connectivity at postintervention relative to preintervention time point. In FEST, the increase in amygdala activation was associated with fewer depressive symptoms (r = 0.72) 6 months after intervention.CONCLUSIONS: Enhanced activation and functional connectivity of the amygdala after FEST versus SEKT may represent a neural marker of improved emotion processing, supporting the FEST intervention as an effective tool in relapse prevention in patients with BD.
AB - BACKGROUND: In bipolar disorder (BD), the alternation of extreme mood states indicates deficits in emotion processing, accompanied by aberrant neural function of the emotion network. The present study investigated the effects of an emotion-centered psychotherapeutic intervention on amygdala responsivity and connectivity during emotional face processing in BD.METHODS: In a randomized controlled trial within the multicentric BipoLife project, euthymic patients with BD received one of two interventions over 6 months: an unstructured, emotion-focused intervention (FEST), where patients were guided to adequately perceive and label their emotions (n = 28), or a specific, structured, cognitive behavioral intervention (SEKT) (n = 31). Before and after interventions, functional magnetic resonance imaging was conducted while patients completed an emotional face-matching paradigm (final functional magnetic resonance imaging sample of patients completing both measurements: SEKT, n = 17; FEST, n = 17). Healthy control subjects (n = 32) were scanned twice after the same interval without receiving any intervention. Given the focus of FEST on emotion processing, we expected FEST to strengthen amygdala activation and connectivity.RESULTS: Clinically, both interventions stabilized patients' euthymic states in terms of affective symptoms. At the neural level, FEST versus SEKT increased amygdala activation and amygdala-insula connectivity at postintervention relative to preintervention time point. In FEST, the increase in amygdala activation was associated with fewer depressive symptoms (r = 0.72) 6 months after intervention.CONCLUSIONS: Enhanced activation and functional connectivity of the amygdala after FEST versus SEKT may represent a neural marker of improved emotion processing, supporting the FEST intervention as an effective tool in relapse prevention in patients with BD.
KW - Humans
KW - Bipolar Disorder
KW - Brain Mapping
KW - Neural Pathways
KW - Amygdala
KW - Emotions/physiology
KW - Psychotherapy
U2 - 10.1016/j.bpsc.2023.02.008
DO - 10.1016/j.bpsc.2023.02.008
M3 - SCORING: Journal article
C2 - 36898634
VL - 8
SP - 750
EP - 759
JO - BIOL PSYCHIAT-COGN N
JF - BIOL PSYCHIAT-COGN N
SN - 2451-9022
IS - 7
ER -