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Cytoglobin overexpression protects against damage-induced fibrosis.

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Cytoglobin overexpression protects against damage-induced fibrosis. / Xu, Ruian; Harrison, Phillip M; Chen, Miao; Li, Linyan; Tsui, Tung Yu; Fung, Peter C W; Cheung, Pik-to; Wang, Guangji; Li, Hua; Diao, Yong; Krissansen, Geoffrey W; Xu, Sue; Farzaneh, Farzin.

In: MOL THER, Vol. 13, No. 6, 6, 2006, p. 1093-1100.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Xu, R, Harrison, PM, Chen, M, Li, L, Tsui, TY, Fung, PCW, Cheung, P, Wang, G, Li, H, Diao, Y, Krissansen, GW, Xu, S & Farzaneh, F 2006, 'Cytoglobin overexpression protects against damage-induced fibrosis.', MOL THER, vol. 13, no. 6, 6, pp. 1093-1100. <http://www.ncbi.nlm.nih.gov/pubmed/16581302?dopt=Citation>

APA

Xu, R., Harrison, P. M., Chen, M., Li, L., Tsui, T. Y., Fung, P. C. W., Cheung, P., Wang, G., Li, H., Diao, Y., Krissansen, G. W., Xu, S., & Farzaneh, F. (2006). Cytoglobin overexpression protects against damage-induced fibrosis. MOL THER, 13(6), 1093-1100. [6]. http://www.ncbi.nlm.nih.gov/pubmed/16581302?dopt=Citation

Vancouver

Xu R, Harrison PM, Chen M, Li L, Tsui TY, Fung PCW et al. Cytoglobin overexpression protects against damage-induced fibrosis. MOL THER. 2006;13(6):1093-1100. 6.

Bibtex

@article{764bd1fb6d8b422c8a17ce2ebf7baee3,
title = "Cytoglobin overexpression protects against damage-induced fibrosis.",
abstract = "Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis.",
author = "Ruian Xu and Harrison, {Phillip M} and Miao Chen and Linyan Li and Tsui, {Tung Yu} and Fung, {Peter C W} and Pik-to Cheung and Guangji Wang and Hua Li and Yong Diao and Krissansen, {Geoffrey W} and Sue Xu and Farzin Farzaneh",
year = "2006",
language = "Deutsch",
volume = "13",
pages = "1093--1100",
journal = "MOL THER",
issn = "1525-0016",
publisher = "NATURE PUBLISHING GROUP",
number = "6",

}

RIS

TY - JOUR

T1 - Cytoglobin overexpression protects against damage-induced fibrosis.

AU - Xu, Ruian

AU - Harrison, Phillip M

AU - Chen, Miao

AU - Li, Linyan

AU - Tsui, Tung Yu

AU - Fung, Peter C W

AU - Cheung, Pik-to

AU - Wang, Guangji

AU - Li, Hua

AU - Diao, Yong

AU - Krissansen, Geoffrey W

AU - Xu, Sue

AU - Farzaneh, Farzin

PY - 2006

Y1 - 2006

N2 - Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis.

AB - Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis.

M3 - SCORING: Zeitschriftenaufsatz

VL - 13

SP - 1093

EP - 1100

JO - MOL THER

JF - MOL THER

SN - 1525-0016

IS - 6

M1 - 6

ER -