Cytoglobin overexpression protects against damage-induced fibrosis.
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Cytoglobin overexpression protects against damage-induced fibrosis. / Xu, Ruian; Harrison, Phillip M; Chen, Miao; Li, Linyan; Tsui, Tung Yu; Fung, Peter C W; Cheung, Pik-to; Wang, Guangji; Li, Hua; Diao, Yong; Krissansen, Geoffrey W; Xu, Sue; Farzaneh, Farzin.
in: MOL THER, Jahrgang 13, Nr. 6, 6, 2006, S. 1093-1100.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cytoglobin overexpression protects against damage-induced fibrosis.
AU - Xu, Ruian
AU - Harrison, Phillip M
AU - Chen, Miao
AU - Li, Linyan
AU - Tsui, Tung Yu
AU - Fung, Peter C W
AU - Cheung, Pik-to
AU - Wang, Guangji
AU - Li, Hua
AU - Diao, Yong
AU - Krissansen, Geoffrey W
AU - Xu, Sue
AU - Farzaneh, Farzin
PY - 2006
Y1 - 2006
N2 - Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis.
AB - Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis.
M3 - SCORING: Zeitschriftenaufsatz
VL - 13
SP - 1093
EP - 1100
JO - MOL THER
JF - MOL THER
SN - 1525-0016
IS - 6
M1 - 6
ER -