Current and Future Concepts for the Treatment of Impaired Fracture Healing
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Current and Future Concepts for the Treatment of Impaired Fracture Healing. / Schlickewei, Carsten W; Kleinertz, Holger; Thiesen, Darius M; Mader, Konrad; Priemel, Matthias; Frosch, Karl-Heinz; Keller, Johannes.
In: INT J MOL SCI, Vol. 20, No. 22, 19.11.2019.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Current and Future Concepts for the Treatment of Impaired Fracture Healing
AU - Schlickewei, Carsten W
AU - Kleinertz, Holger
AU - Thiesen, Darius M
AU - Mader, Konrad
AU - Priemel, Matthias
AU - Frosch, Karl-Heinz
AU - Keller, Johannes
PY - 2019/11/19
Y1 - 2019/11/19
N2 - Bone regeneration represents a complex process, of which basic biologic principles have been evolutionarily conserved over a broad range of different species. Bone represents one of few tissues that can heal without forming a fibrous scar and, as such, resembles a unique form of tissue regeneration. Despite a tremendous improvement in surgical techniques in the past decades, impaired bone regeneration including non-unions still affect a significant number of patients with fractures. As impaired bone regeneration is associated with high socio-economic implications, it is an essential clinical need to gain a full understanding of the pathophysiology and identify novel treatment approaches. This review focuses on the clinical implications of impaired bone regeneration, including currently available treatment options. Moreover, recent advances in the understanding of fracture healing are discussed, which have resulted in the identification and development of novel therapeutic approaches for affected patients.
AB - Bone regeneration represents a complex process, of which basic biologic principles have been evolutionarily conserved over a broad range of different species. Bone represents one of few tissues that can heal without forming a fibrous scar and, as such, resembles a unique form of tissue regeneration. Despite a tremendous improvement in surgical techniques in the past decades, impaired bone regeneration including non-unions still affect a significant number of patients with fractures. As impaired bone regeneration is associated with high socio-economic implications, it is an essential clinical need to gain a full understanding of the pathophysiology and identify novel treatment approaches. This review focuses on the clinical implications of impaired bone regeneration, including currently available treatment options. Moreover, recent advances in the understanding of fracture healing are discussed, which have resulted in the identification and development of novel therapeutic approaches for affected patients.
U2 - 10.3390/ijms20225805
DO - 10.3390/ijms20225805
M3 - SCORING: Review article
C2 - 31752267
VL - 20
JO - INT J MOL SCI
JF - INT J MOL SCI
SN - 1661-6596
IS - 22
ER -