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Current and Future Concepts for the Treatment of Impaired Fracture Healing

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Current and Future Concepts for the Treatment of Impaired Fracture Healing. / Schlickewei, Carsten W; Kleinertz, Holger; Thiesen, Darius M; Mader, Konrad; Priemel, Matthias; Frosch, Karl-Heinz; Keller, Johannes.

in: INT J MOL SCI, Jahrgang 20, Nr. 22, 19.11.2019.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Schlickewei, CW, Kleinertz, H, Thiesen, DM, Mader, K, Priemel, M, Frosch, K-H & Keller, J 2019, 'Current and Future Concepts for the Treatment of Impaired Fracture Healing', INT J MOL SCI, Jg. 20, Nr. 22. https://doi.org/10.3390/ijms20225805

APA

Schlickewei, C. W., Kleinertz, H., Thiesen, D. M., Mader, K., Priemel, M., Frosch, K-H., & Keller, J. (2019). Current and Future Concepts for the Treatment of Impaired Fracture Healing. INT J MOL SCI, 20(22). https://doi.org/10.3390/ijms20225805

Vancouver

Schlickewei CW, Kleinertz H, Thiesen DM, Mader K, Priemel M, Frosch K-H et al. Current and Future Concepts for the Treatment of Impaired Fracture Healing. INT J MOL SCI. 2019 Nov 19;20(22). https://doi.org/10.3390/ijms20225805

Bibtex

@article{5c52e92623f34cf78e28cefd71952588,
title = "Current and Future Concepts for the Treatment of Impaired Fracture Healing",
abstract = "Bone regeneration represents a complex process, of which basic biologic principles have been evolutionarily conserved over a broad range of different species. Bone represents one of few tissues that can heal without forming a fibrous scar and, as such, resembles a unique form of tissue regeneration. Despite a tremendous improvement in surgical techniques in the past decades, impaired bone regeneration including non-unions still affect a significant number of patients with fractures. As impaired bone regeneration is associated with high socio-economic implications, it is an essential clinical need to gain a full understanding of the pathophysiology and identify novel treatment approaches. This review focuses on the clinical implications of impaired bone regeneration, including currently available treatment options. Moreover, recent advances in the understanding of fracture healing are discussed, which have resulted in the identification and development of novel therapeutic approaches for affected patients.",
author = "Schlickewei, {Carsten W} and Holger Kleinertz and Thiesen, {Darius M} and Konrad Mader and Matthias Priemel and Karl-Heinz Frosch and Johannes Keller",
year = "2019",
month = nov,
day = "19",
doi = "10.3390/ijms20225805",
language = "English",
volume = "20",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "22",

}

RIS

TY - JOUR

T1 - Current and Future Concepts for the Treatment of Impaired Fracture Healing

AU - Schlickewei, Carsten W

AU - Kleinertz, Holger

AU - Thiesen, Darius M

AU - Mader, Konrad

AU - Priemel, Matthias

AU - Frosch, Karl-Heinz

AU - Keller, Johannes

PY - 2019/11/19

Y1 - 2019/11/19

N2 - Bone regeneration represents a complex process, of which basic biologic principles have been evolutionarily conserved over a broad range of different species. Bone represents one of few tissues that can heal without forming a fibrous scar and, as such, resembles a unique form of tissue regeneration. Despite a tremendous improvement in surgical techniques in the past decades, impaired bone regeneration including non-unions still affect a significant number of patients with fractures. As impaired bone regeneration is associated with high socio-economic implications, it is an essential clinical need to gain a full understanding of the pathophysiology and identify novel treatment approaches. This review focuses on the clinical implications of impaired bone regeneration, including currently available treatment options. Moreover, recent advances in the understanding of fracture healing are discussed, which have resulted in the identification and development of novel therapeutic approaches for affected patients.

AB - Bone regeneration represents a complex process, of which basic biologic principles have been evolutionarily conserved over a broad range of different species. Bone represents one of few tissues that can heal without forming a fibrous scar and, as such, resembles a unique form of tissue regeneration. Despite a tremendous improvement in surgical techniques in the past decades, impaired bone regeneration including non-unions still affect a significant number of patients with fractures. As impaired bone regeneration is associated with high socio-economic implications, it is an essential clinical need to gain a full understanding of the pathophysiology and identify novel treatment approaches. This review focuses on the clinical implications of impaired bone regeneration, including currently available treatment options. Moreover, recent advances in the understanding of fracture healing are discussed, which have resulted in the identification and development of novel therapeutic approaches for affected patients.

U2 - 10.3390/ijms20225805

DO - 10.3390/ijms20225805

M3 - SCORING: Review article

C2 - 31752267

VL - 20

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 22

ER -