C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats.
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C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats. / Montkowski, A; Jahn, Holger; Ströhle, A; Poettig, M; Holsboer, F; Wiedemann, Klaus.
In: BRAIN RES, Vol. 792, No. 2, 2, 1998, p. 358-360.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats.
AU - Montkowski, A
AU - Jahn, Holger
AU - Ströhle, A
AU - Poettig, M
AU - Holsboer, F
AU - Wiedemann, Klaus
PY - 1998
Y1 - 1998
N2 - As evidence exists that C-type natriuretic peptide (CNP) exerts effects opposing those of atrial natriuretic peptide (ANP), we studied the behavioural properties of CNP after central infusion in rats by their performance in the elevated plus maze. Doses of 0.5 microg and 5 microg i.c.v. had distinct anxiogenic properties. Our data suggest opposing effects of CNP and ANP on anxiety-related behaviour in rats, which appear to be mediated via different receptor occupation and brain regions by a corticotropin-releasing hormone (CRH)-dependent mechanism.
AB - As evidence exists that C-type natriuretic peptide (CNP) exerts effects opposing those of atrial natriuretic peptide (ANP), we studied the behavioural properties of CNP after central infusion in rats by their performance in the elevated plus maze. Doses of 0.5 microg and 5 microg i.c.v. had distinct anxiogenic properties. Our data suggest opposing effects of CNP and ANP on anxiety-related behaviour in rats, which appear to be mediated via different receptor occupation and brain regions by a corticotropin-releasing hormone (CRH)-dependent mechanism.
M3 - SCORING: Zeitschriftenaufsatz
VL - 792
SP - 358
EP - 360
JO - BRAIN RES
JF - BRAIN RES
SN - 0006-8993
IS - 2
M1 - 2
ER -