Cryo-EM structures of actin binding proteins as tool for drug discovery
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Cryo-EM structures of actin binding proteins as tool for drug discovery. / Dahlstroem, Christian; Paraschiakos, Themistoklis; Sun, Han; Windhorst, Sabine.
In: BIOCHEM PHARMACOL, Vol. 214, 08.2023, p. 115680.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Cryo-EM structures of actin binding proteins as tool for drug discovery
AU - Dahlstroem, Christian
AU - Paraschiakos, Themistoklis
AU - Sun, Han
AU - Windhorst, Sabine
N1 - Copyright © 2023 Elsevier Inc. All rights reserved.
PY - 2023/8
Y1 - 2023/8
N2 - Cellular actin dynamic is controlled by a plethora of actin binding proteins (ABPs), including actin nucleating, bundling, cross-linking, capping, and severing proteins. In this review, regulation of actin dynamics by ABPs will be introduced, and the role of the F-actin severing protein cofilin-1 and the F-actin bundling protein L-plastin in actin dynamics discussed in more detail. Since up-regulation of these proteins in different kinds of cancers is associated with malignant progression of cancer cells, we suggest the cryogenic electron microscopy (Cryo-EM) structure of F- actin with the respective ABP as template for in silico drug design to specifically disrupt the interaction of these ABPs with F-actin.
AB - Cellular actin dynamic is controlled by a plethora of actin binding proteins (ABPs), including actin nucleating, bundling, cross-linking, capping, and severing proteins. In this review, regulation of actin dynamics by ABPs will be introduced, and the role of the F-actin severing protein cofilin-1 and the F-actin bundling protein L-plastin in actin dynamics discussed in more detail. Since up-regulation of these proteins in different kinds of cancers is associated with malignant progression of cancer cells, we suggest the cryogenic electron microscopy (Cryo-EM) structure of F- actin with the respective ABP as template for in silico drug design to specifically disrupt the interaction of these ABPs with F-actin.
U2 - 10.1016/j.bcp.2023.115680
DO - 10.1016/j.bcp.2023.115680
M3 - SCORING: Review article
C2 - 37399949
VL - 214
SP - 115680
JO - BIOCHEM PHARMACOL
JF - BIOCHEM PHARMACOL
SN - 0006-2952
ER -