Cryo-EM structures of actin binding proteins as tool for drug discovery

Christian Dahlstroem; Themistoklis Paraschiakos; Han Sun; Sabine Windhorst

doi:10.1016/j.bcp.2023.115680

Cryo-EM structures of actin binding proteins as tool for drug discovery

Standard

Cryo-EM structures of actin binding proteins as tool for drug discovery. / Dahlstroem, Christian; Paraschiakos, Themistoklis; Sun, Han; Windhorst, Sabine.

in: BIOCHEM PHARMACOL, Jahrgang 214, 08.2023, S. 115680.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Dahlstroem, C, Paraschiakos, T, Sun, H & Windhorst, S 2023, 'Cryo-EM structures of actin binding proteins as tool for drug discovery', BIOCHEM PHARMACOL, Jg. 214, S. 115680. https://doi.org/10.1016/j.bcp.2023.115680

APA

Dahlstroem, C., Paraschiakos, T., Sun, H., & Windhorst, S. (2023). Cryo-EM structures of actin binding proteins as tool for drug discovery. BIOCHEM PHARMACOL, 214, 115680. https://doi.org/10.1016/j.bcp.2023.115680

Vancouver

Dahlstroem C, Paraschiakos T, Sun H, Windhorst S. Cryo-EM structures of actin binding proteins as tool for drug discovery. BIOCHEM PHARMACOL. 2023 Aug;214:115680. https://doi.org/10.1016/j.bcp.2023.115680

Bibtex

@article{89fd62587da94af19a63dba0e37ac95e,

title = "Cryo-EM structures of actin binding proteins as tool for drug discovery",

abstract = "Cellular actin dynamic is controlled by a plethora of actin binding proteins (ABPs), including actin nucleating, bundling, cross-linking, capping, and severing proteins. In this review, regulation of actin dynamics by ABPs will be introduced, and the role of the F-actin severing protein cofilin-1 and the F-actin bundling protein L-plastin in actin dynamics discussed in more detail. Since up-regulation of these proteins in different kinds of cancers is associated with malignant progression of cancer cells, we suggest the cryogenic electron microscopy (Cryo-EM) structure of F- actin with the respective ABP as template for in silico drug design to specifically disrupt the interaction of these ABPs with F-actin.",

author = "Christian Dahlstroem and Themistoklis Paraschiakos and Han Sun and Sabine Windhorst",

year = "2023",

month = aug,

doi = "10.1016/j.bcp.2023.115680",

language = "English",

volume = "214",

pages = "115680",

journal = "BIOCHEM PHARMACOL",

issn = "0006-2952",

publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Cryo-EM structures of actin binding proteins as tool for drug discovery

AU - Dahlstroem, Christian

AU - Paraschiakos, Themistoklis

AU - Sun, Han

AU - Windhorst, Sabine

PY - 2023/8

Y1 - 2023/8

N2 - Cellular actin dynamic is controlled by a plethora of actin binding proteins (ABPs), including actin nucleating, bundling, cross-linking, capping, and severing proteins. In this review, regulation of actin dynamics by ABPs will be introduced, and the role of the F-actin severing protein cofilin-1 and the F-actin bundling protein L-plastin in actin dynamics discussed in more detail. Since up-regulation of these proteins in different kinds of cancers is associated with malignant progression of cancer cells, we suggest the cryogenic electron microscopy (Cryo-EM) structure of F- actin with the respective ABP as template for in silico drug design to specifically disrupt the interaction of these ABPs with F-actin.

AB - Cellular actin dynamic is controlled by a plethora of actin binding proteins (ABPs), including actin nucleating, bundling, cross-linking, capping, and severing proteins. In this review, regulation of actin dynamics by ABPs will be introduced, and the role of the F-actin severing protein cofilin-1 and the F-actin bundling protein L-plastin in actin dynamics discussed in more detail. Since up-regulation of these proteins in different kinds of cancers is associated with malignant progression of cancer cells, we suggest the cryogenic electron microscopy (Cryo-EM) structure of F- actin with the respective ABP as template for in silico drug design to specifically disrupt the interaction of these ABPs with F-actin.

U2 - 10.1016/j.bcp.2023.115680

DO - 10.1016/j.bcp.2023.115680

M3 - SCORING: Review article

C2 - 37399949

VL - 214

SP - 115680

JO - BIOCHEM PHARMACOL

JF - BIOCHEM PHARMACOL

SN - 0006-2952

ER -