Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
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Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. / Loyal, Lucie; Braun, Julian; Henze, Larissa; Kruse, Beate; Dingeldey, Manuela; Reimer, Ulf; Kern, Florian; Schwarz, Tatjana; Mangold, Maike; Unger, Clara; Dörfler, Friederike; Kadler, Shirin; Rosowski, Jennifer; Gürcan, Kübrah; Uyar-Aydin, Zehra; Frentsch, Marco; Kurth, Florian; Schnatbaum, Karsten; Eckey, Maren; Hippenstiel, Stefan; Hocke, Andreas; Müller, Marcel A; Sawitzki, Birgit; Miltenyi, Stefan; Paul, Friedemann; Mall, Marcus A; Wenschuh, Holger; Voigt, Sebastian; Drosten, Christian; Lauster, Roland; Lachman, Nils; Sander, Leif-Erik; Corman, Victor M; Röhmel, Jobst; Meyer-Arndt, Lil; Thiel, Andreas; Giesecke-Thiel, Claudia.
In: SCIENCE, Vol. 374, No. 6564, 08.10.2021, p. eabh1823.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
AU - Loyal, Lucie
AU - Braun, Julian
AU - Henze, Larissa
AU - Kruse, Beate
AU - Dingeldey, Manuela
AU - Reimer, Ulf
AU - Kern, Florian
AU - Schwarz, Tatjana
AU - Mangold, Maike
AU - Unger, Clara
AU - Dörfler, Friederike
AU - Kadler, Shirin
AU - Rosowski, Jennifer
AU - Gürcan, Kübrah
AU - Uyar-Aydin, Zehra
AU - Frentsch, Marco
AU - Kurth, Florian
AU - Schnatbaum, Karsten
AU - Eckey, Maren
AU - Hippenstiel, Stefan
AU - Hocke, Andreas
AU - Müller, Marcel A
AU - Sawitzki, Birgit
AU - Miltenyi, Stefan
AU - Paul, Friedemann
AU - Mall, Marcus A
AU - Wenschuh, Holger
AU - Voigt, Sebastian
AU - Drosten, Christian
AU - Lauster, Roland
AU - Lachman, Nils
AU - Sander, Leif-Erik
AU - Corman, Victor M
AU - Röhmel, Jobst
AU - Meyer-Arndt, Lil
AU - Thiel, Andreas
AU - Giesecke-Thiel, Claudia
PY - 2021/10/8
Y1 - 2021/10/8
N2 - The functional relevance of preexisting cross-immunity to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemiccoronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4+T cells are ubiquitous but decreasewith age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830)and demonstrate that preexisting spike- and S816-830–reactive T cells were recruited into immuneresponses to SARS-CoV-2 infection and their frequency correlated with anti–SARS-CoV-2-S1-IgGantibodies. Spike–cross-reactive T cells were also activated after primary BNT162b2 COVID-19messenger RNA vaccination and displayed kinetics similar to those of secondary immune responses.Our results highlight the functional contribution of preexisting spike–cross-reactive T cells inSARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapidinduction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic ormild COVID-19 disease courses.
AB - The functional relevance of preexisting cross-immunity to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemiccoronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4+T cells are ubiquitous but decreasewith age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830)and demonstrate that preexisting spike- and S816-830–reactive T cells were recruited into immuneresponses to SARS-CoV-2 infection and their frequency correlated with anti–SARS-CoV-2-S1-IgGantibodies. Spike–cross-reactive T cells were also activated after primary BNT162b2 COVID-19messenger RNA vaccination and displayed kinetics similar to those of secondary immune responses.Our results highlight the functional contribution of preexisting spike–cross-reactive T cells inSARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapidinduction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic ormild COVID-19 disease courses.
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Asymptomatic Diseases
KW - BNT162 Vaccine
KW - CD3 Complex/immunology
KW - CD4-Positive T-Lymphocytes/immunology
KW - COVID-19/immunology
KW - COVID-19 Vaccines/immunology
KW - Cross Reactions
KW - Female
KW - Humans
KW - Immunity
KW - Immunodominant Epitopes/immunology
KW - Male
KW - Middle Aged
KW - Open Reading Frames
KW - Peptide Fragments/immunology
KW - SARS-CoV-2/genetics
KW - Spike Glycoprotein, Coronavirus/immunology
KW - Vaccination
KW - Young Adult
U2 - 10.1126/science.abh1823
DO - 10.1126/science.abh1823
M3 - SCORING: Journal article
C2 - 34465633
VL - 374
SP - eabh1823
JO - SCIENCE
JF - SCIENCE
SN - 0036-8075
IS - 6564
ER -