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Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

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Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. / Loyal, Lucie; Braun, Julian; Henze, Larissa; Kruse, Beate; Dingeldey, Manuela; Reimer, Ulf; Kern, Florian; Schwarz, Tatjana; Mangold, Maike; Unger, Clara; Dörfler, Friederike; Kadler, Shirin; Rosowski, Jennifer; Gürcan, Kübrah; Uyar-Aydin, Zehra; Frentsch, Marco; Kurth, Florian; Schnatbaum, Karsten; Eckey, Maren; Hippenstiel, Stefan; Hocke, Andreas; Müller, Marcel A; Sawitzki, Birgit; Miltenyi, Stefan; Paul, Friedemann; Mall, Marcus A; Wenschuh, Holger; Voigt, Sebastian; Drosten, Christian; Lauster, Roland; Lachman, Nils; Sander, Leif-Erik; Corman, Victor M; Röhmel, Jobst; Meyer-Arndt, Lil; Thiel, Andreas; Giesecke-Thiel, Claudia.

in: SCIENCE, Jahrgang 374, Nr. 6564, 08.10.2021, S. eabh1823.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Loyal, L, Braun, J, Henze, L, Kruse, B, Dingeldey, M, Reimer, U, Kern, F, Schwarz, T, Mangold, M, Unger, C, Dörfler, F, Kadler, S, Rosowski, J, Gürcan, K, Uyar-Aydin, Z, Frentsch, M, Kurth, F, Schnatbaum, K, Eckey, M, Hippenstiel, S, Hocke, A, Müller, MA, Sawitzki, B, Miltenyi, S, Paul, F, Mall, MA, Wenschuh, H, Voigt, S, Drosten, C, Lauster, R, Lachman, N, Sander, L-E, Corman, VM, Röhmel, J, Meyer-Arndt, L, Thiel, A & Giesecke-Thiel, C 2021, 'Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination', SCIENCE, Jg. 374, Nr. 6564, S. eabh1823. https://doi.org/10.1126/science.abh1823

APA

Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., Kern, F., Schwarz, T., Mangold, M., Unger, C., Dörfler, F., Kadler, S., Rosowski, J., Gürcan, K., Uyar-Aydin, Z., Frentsch, M., Kurth, F., Schnatbaum, K., Eckey, M., ... Giesecke-Thiel, C. (2021). Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. SCIENCE, 374(6564), eabh1823. https://doi.org/10.1126/science.abh1823

Vancouver

Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U et al. Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. SCIENCE. 2021 Okt 8;374(6564):eabh1823. https://doi.org/10.1126/science.abh1823

Bibtex

@article{098de83c0aae4b12ade30a36d8087140,
title = "Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination",
abstract = "The functional relevance of preexisting cross-immunity to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemiccoronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4+T cells are ubiquitous but decreasewith age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830)and demonstrate that preexisting spike- and S816-830–reactive T cells were recruited into immuneresponses to SARS-CoV-2 infection and their frequency correlated with anti–SARS-CoV-2-S1-IgGantibodies. Spike–cross-reactive T cells were also activated after primary BNT162b2 COVID-19messenger RNA vaccination and displayed kinetics similar to those of secondary immune responses.Our results highlight the functional contribution of preexisting spike–cross-reactive T cells inSARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapidinduction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic ormild COVID-19 disease courses.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Asymptomatic Diseases, BNT162 Vaccine, CD3 Complex/immunology, CD4-Positive T-Lymphocytes/immunology, COVID-19/immunology, COVID-19 Vaccines/immunology, Cross Reactions, Female, Humans, Immunity, Immunodominant Epitopes/immunology, Male, Middle Aged, Open Reading Frames, Peptide Fragments/immunology, SARS-CoV-2/genetics, Spike Glycoprotein, Coronavirus/immunology, Vaccination, Young Adult",
author = "Lucie Loyal and Julian Braun and Larissa Henze and Beate Kruse and Manuela Dingeldey and Ulf Reimer and Florian Kern and Tatjana Schwarz and Maike Mangold and Clara Unger and Friederike D{\"o}rfler and Shirin Kadler and Jennifer Rosowski and K{\"u}brah G{\"u}rcan and Zehra Uyar-Aydin and Marco Frentsch and Florian Kurth and Karsten Schnatbaum and Maren Eckey and Stefan Hippenstiel and Andreas Hocke and M{\"u}ller, {Marcel A} and Birgit Sawitzki and Stefan Miltenyi and Friedemann Paul and Mall, {Marcus A} and Holger Wenschuh and Sebastian Voigt and Christian Drosten and Roland Lauster and Nils Lachman and Leif-Erik Sander and Corman, {Victor M} and Jobst R{\"o}hmel and Lil Meyer-Arndt and Andreas Thiel and Claudia Giesecke-Thiel",
year = "2021",
month = oct,
day = "8",
doi = "10.1126/science.abh1823",
language = "English",
volume = "374",
pages = "eabh1823",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6564",

}

RIS

TY - JOUR

T1 - Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

AU - Loyal, Lucie

AU - Braun, Julian

AU - Henze, Larissa

AU - Kruse, Beate

AU - Dingeldey, Manuela

AU - Reimer, Ulf

AU - Kern, Florian

AU - Schwarz, Tatjana

AU - Mangold, Maike

AU - Unger, Clara

AU - Dörfler, Friederike

AU - Kadler, Shirin

AU - Rosowski, Jennifer

AU - Gürcan, Kübrah

AU - Uyar-Aydin, Zehra

AU - Frentsch, Marco

AU - Kurth, Florian

AU - Schnatbaum, Karsten

AU - Eckey, Maren

AU - Hippenstiel, Stefan

AU - Hocke, Andreas

AU - Müller, Marcel A

AU - Sawitzki, Birgit

AU - Miltenyi, Stefan

AU - Paul, Friedemann

AU - Mall, Marcus A

AU - Wenschuh, Holger

AU - Voigt, Sebastian

AU - Drosten, Christian

AU - Lauster, Roland

AU - Lachman, Nils

AU - Sander, Leif-Erik

AU - Corman, Victor M

AU - Röhmel, Jobst

AU - Meyer-Arndt, Lil

AU - Thiel, Andreas

AU - Giesecke-Thiel, Claudia

PY - 2021/10/8

Y1 - 2021/10/8

N2 - The functional relevance of preexisting cross-immunity to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemiccoronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4+T cells are ubiquitous but decreasewith age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830)and demonstrate that preexisting spike- and S816-830–reactive T cells were recruited into immuneresponses to SARS-CoV-2 infection and their frequency correlated with anti–SARS-CoV-2-S1-IgGantibodies. Spike–cross-reactive T cells were also activated after primary BNT162b2 COVID-19messenger RNA vaccination and displayed kinetics similar to those of secondary immune responses.Our results highlight the functional contribution of preexisting spike–cross-reactive T cells inSARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapidinduction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic ormild COVID-19 disease courses.

AB - The functional relevance of preexisting cross-immunity to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemiccoronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4+T cells are ubiquitous but decreasewith age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830)and demonstrate that preexisting spike- and S816-830–reactive T cells were recruited into immuneresponses to SARS-CoV-2 infection and their frequency correlated with anti–SARS-CoV-2-S1-IgGantibodies. Spike–cross-reactive T cells were also activated after primary BNT162b2 COVID-19messenger RNA vaccination and displayed kinetics similar to those of secondary immune responses.Our results highlight the functional contribution of preexisting spike–cross-reactive T cells inSARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapidinduction of immunity after primary SARS-CoV-2 immunization and the high rate of asymptomatic ormild COVID-19 disease courses.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Asymptomatic Diseases

KW - BNT162 Vaccine

KW - CD3 Complex/immunology

KW - CD4-Positive T-Lymphocytes/immunology

KW - COVID-19/immunology

KW - COVID-19 Vaccines/immunology

KW - Cross Reactions

KW - Female

KW - Humans

KW - Immunity

KW - Immunodominant Epitopes/immunology

KW - Male

KW - Middle Aged

KW - Open Reading Frames

KW - Peptide Fragments/immunology

KW - SARS-CoV-2/genetics

KW - Spike Glycoprotein, Coronavirus/immunology

KW - Vaccination

KW - Young Adult

U2 - 10.1126/science.abh1823

DO - 10.1126/science.abh1823

M3 - SCORING: Journal article

C2 - 34465633

VL - 374

SP - eabh1823

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6564

ER -