Critical role of CD28 in protective immunity against Salmonella typhimurium
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Critical role of CD28 in protective immunity against Salmonella typhimurium. / Mittrücker, H W; Köhler, A; Mak, T W; Kaufmann, S H.
In: J IMMUNOL, Vol. 163, No. 12, 15.12.1999, p. 6769-76.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Critical role of CD28 in protective immunity against Salmonella typhimurium
AU - Mittrücker, H W
AU - Köhler, A
AU - Mak, T W
AU - Kaufmann, S H
PY - 1999/12/15
Y1 - 1999/12/15
N2 - Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28-/- mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with attenuated aroA- S. typhimurium. More detailed analysis revealed that CD28-/- animals did not mount a T-dependent Ab response and were highly impaired in the production of IFN-gamma. Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen.
AB - Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28-/- mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with attenuated aroA- S. typhimurium. More detailed analysis revealed that CD28-/- animals did not mount a T-dependent Ab response and were highly impaired in the production of IFN-gamma. Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen.
KW - Animals
KW - Antibodies, Bacterial
KW - Antibody Specificity
KW - Antigens, CD28
KW - Carrier Proteins
KW - Cation Transport Proteins
KW - Genetic Predisposition to Disease
KW - Immune Sera
KW - Immunity, Innate
KW - Interferon-gamma
KW - Membrane Proteins
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Mutant Strains
KW - Salmonella Infections, Animal
KW - Salmonella typhimurium
KW - T-Lymphocytes
M3 - SCORING: Journal article
C2 - 10586076
VL - 163
SP - 6769
EP - 6776
JO - J IMMUNOL
JF - J IMMUNOL
SN - 0022-1767
IS - 12
ER -