Critical role of CD28 in protective immunity against Salmonella typhimurium

H W Mittrücker; A Köhler; T W Mak; S H Kaufmann

Critical role of CD28 in protective immunity against Salmonella typhimurium

Standard

Critical role of CD28 in protective immunity against Salmonella typhimurium. / Mittrücker, H W; Köhler, A; Mak, T W; Kaufmann, S H.

in: J IMMUNOL, Jahrgang 163, Nr. 12, 15.12.1999, S. 6769-76.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mittrücker, HW, Köhler, A, Mak, TW & Kaufmann, SH 1999, 'Critical role of CD28 in protective immunity against Salmonella typhimurium', J IMMUNOL, Jg. 163, Nr. 12, S. 6769-76.

APA

Mittrücker, H. W., Köhler, A., Mak, T. W., & Kaufmann, S. H. (1999). Critical role of CD28 in protective immunity against Salmonella typhimurium. J IMMUNOL, 163(12), 6769-76.

Vancouver

Mittrücker HW, Köhler A, Mak TW, Kaufmann SH. Critical role of CD28 in protective immunity against Salmonella typhimurium. J IMMUNOL. 1999 Dez 15;163(12):6769-76.

Bibtex

@article{04ecacfed7bf419999cad520ca49e513,

title = "Critical role of CD28 in protective immunity against Salmonella typhimurium",

abstract = "Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28-/- mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with attenuated aroA- S. typhimurium. More detailed analysis revealed that CD28-/- animals did not mount a T-dependent Ab response and were highly impaired in the production of IFN-gamma. Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen.",

keywords = "Animals, Antibodies, Bacterial, Antibody Specificity, Antigens, CD28, Carrier Proteins, Cation Transport Proteins, Genetic Predisposition to Disease, Immune Sera, Immunity, Innate, Interferon-gamma, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Salmonella Infections, Animal, Salmonella typhimurium, T-Lymphocytes",

author = "Mittr{\"u}cker, {H W} and A K{\"o}hler and Mak, {T W} and Kaufmann, {S H}",

year = "1999",

month = dec,

day = "15",

language = "English",

volume = "163",

pages = "6769--76",

journal = "J IMMUNOL",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "12",

}

RIS

TY - JOUR

T1 - Critical role of CD28 in protective immunity against Salmonella typhimurium

AU - Mittrücker, H W

AU - Köhler, A

AU - Mak, T W

AU - Kaufmann, S H

PY - 1999/12/15

Y1 - 1999/12/15

N2 - Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28-/- mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with attenuated aroA- S. typhimurium. More detailed analysis revealed that CD28-/- animals did not mount a T-dependent Ab response and were highly impaired in the production of IFN-gamma. Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen.

AB - Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28-/- mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with attenuated aroA- S. typhimurium. More detailed analysis revealed that CD28-/- animals did not mount a T-dependent Ab response and were highly impaired in the production of IFN-gamma. Thus, CD28 cosignaling is crucial for immunity against S. typhimurium. To our knowledge, this is the first report describing an essential role for CD28 in protective immunity against an intracellular microbial pathogen.

KW - Animals

KW - Antibodies, Bacterial

KW - Antibody Specificity

KW - Antigens, CD28

KW - Carrier Proteins

KW - Cation Transport Proteins

KW - Genetic Predisposition to Disease

KW - Immune Sera

KW - Immunity, Innate

KW - Interferon-gamma

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Mutant Strains

KW - Salmonella Infections, Animal

KW - Salmonella typhimurium

KW - T-Lymphocytes

M3 - SCORING: Journal article

C2 - 10586076

VL - 163

SP - 6769

EP - 6776

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 12

ER -