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Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells

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Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells. / Ziętara, Natalia; Łyszkiewicz, Marcin; Witzlau, Katrin; Naumann, Ronald; Hurwitz, Robert; Langemeier, Jörg; Bohne, Jens; Sandrock, Inga; Ballmaier, Matthias; Weiss, Siegfried; Prinz, Immo; Krueger, Andreas.

In: P NATL ACAD SCI USA, Vol. 110, No. 18, 30.04.2013, p. 7407-12.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ziętara, N, Łyszkiewicz, M, Witzlau, K, Naumann, R, Hurwitz, R, Langemeier, J, Bohne, J, Sandrock, I, Ballmaier, M, Weiss, S, Prinz, I & Krueger, A 2013, 'Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells', P NATL ACAD SCI USA, vol. 110, no. 18, pp. 7407-12. https://doi.org/10.1073/pnas.1221984110

APA

Ziętara, N., Łyszkiewicz, M., Witzlau, K., Naumann, R., Hurwitz, R., Langemeier, J., Bohne, J., Sandrock, I., Ballmaier, M., Weiss, S., Prinz, I., & Krueger, A. (2013). Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells. P NATL ACAD SCI USA, 110(18), 7407-12. https://doi.org/10.1073/pnas.1221984110

Vancouver

Ziętara N, Łyszkiewicz M, Witzlau K, Naumann R, Hurwitz R, Langemeier J et al. Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells. P NATL ACAD SCI USA. 2013 Apr 30;110(18):7407-12. https://doi.org/10.1073/pnas.1221984110

Bibtex

@article{25a15fd8695747baad4570995f73708a,
title = "Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells",
abstract = "T-cell receptor (TCR) signal strength determines selection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development. Members of the miR-181 family constitute the most abundantly expressed microRNA at this stage of T-cell development. Here we show that deletion of miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually abrogated early invariant natural killer T (iNKT) cell development, resulting in a dramatic reduction in iNKT cell numbers in thymus as well as in the periphery. Increased concentrations of agonist ligand rescued iNKT cell development in miR-181a/b-1(-/-) mice. Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection.",
keywords = "Animals, Cell Proliferation, Clonal Selection, Antigen-Mediated/immunology, Ligands, Mice, Mice, Inbred C57BL, MicroRNAs/genetics, Natural Killer T-Cells/cytology, Receptors, Antigen, T-Cell, alpha-beta/metabolism",
author = "Natalia Zi{\c e}tara and Marcin {\L}yszkiewicz and Katrin Witzlau and Ronald Naumann and Robert Hurwitz and J{\"o}rg Langemeier and Jens Bohne and Inga Sandrock and Matthias Ballmaier and Siegfried Weiss and Immo Prinz and Andreas Krueger",
year = "2013",
month = apr,
day = "30",
doi = "10.1073/pnas.1221984110",
language = "English",
volume = "110",
pages = "7407--12",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "18",

}

RIS

TY - JOUR

T1 - Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells

AU - Ziętara, Natalia

AU - Łyszkiewicz, Marcin

AU - Witzlau, Katrin

AU - Naumann, Ronald

AU - Hurwitz, Robert

AU - Langemeier, Jörg

AU - Bohne, Jens

AU - Sandrock, Inga

AU - Ballmaier, Matthias

AU - Weiss, Siegfried

AU - Prinz, Immo

AU - Krueger, Andreas

PY - 2013/4/30

Y1 - 2013/4/30

N2 - T-cell receptor (TCR) signal strength determines selection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development. Members of the miR-181 family constitute the most abundantly expressed microRNA at this stage of T-cell development. Here we show that deletion of miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually abrogated early invariant natural killer T (iNKT) cell development, resulting in a dramatic reduction in iNKT cell numbers in thymus as well as in the periphery. Increased concentrations of agonist ligand rescued iNKT cell development in miR-181a/b-1(-/-) mice. Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection.

AB - T-cell receptor (TCR) signal strength determines selection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development. Members of the miR-181 family constitute the most abundantly expressed microRNA at this stage of T-cell development. Here we show that deletion of miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually abrogated early invariant natural killer T (iNKT) cell development, resulting in a dramatic reduction in iNKT cell numbers in thymus as well as in the periphery. Increased concentrations of agonist ligand rescued iNKT cell development in miR-181a/b-1(-/-) mice. Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection.

KW - Animals

KW - Cell Proliferation

KW - Clonal Selection, Antigen-Mediated/immunology

KW - Ligands

KW - Mice

KW - Mice, Inbred C57BL

KW - MicroRNAs/genetics

KW - Natural Killer T-Cells/cytology

KW - Receptors, Antigen, T-Cell, alpha-beta/metabolism

U2 - 10.1073/pnas.1221984110

DO - 10.1073/pnas.1221984110

M3 - SCORING: Journal article

C2 - 23589855

VL - 110

SP - 7407

EP - 7412

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 18

ER -