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CRIP1 expression in monocytes related to hypertension

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CRIP1 expression in monocytes related to hypertension. / Schweigert, Olga; Adler, Julia; Längst, Natalie; Aïssi, Dylan; Duque Escobar, Jorge; Tong, Teng; Müller, Christian; Trégouët, David-Alexandre; Lukowski, Robert; Zeller, Tanja.

In: CLIN SCI, Vol. 135, No. 7, 16.04.2021, p. 911-924.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schweigert, O, Adler, J, Längst, N, Aïssi, D, Duque Escobar, J, Tong, T, Müller, C, Trégouët, D-A, Lukowski, R & Zeller, T 2021, 'CRIP1 expression in monocytes related to hypertension', CLIN SCI, vol. 135, no. 7, pp. 911-924. https://doi.org/10.1042/CS20201372

APA

Schweigert, O., Adler, J., Längst, N., Aïssi, D., Duque Escobar, J., Tong, T., Müller, C., Trégouët, D-A., Lukowski, R., & Zeller, T. (2021). CRIP1 expression in monocytes related to hypertension. CLIN SCI, 135(7), 911-924. https://doi.org/10.1042/CS20201372

Vancouver

Schweigert O, Adler J, Längst N, Aïssi D, Duque Escobar J, Tong T et al. CRIP1 expression in monocytes related to hypertension. CLIN SCI. 2021 Apr 16;135(7):911-924. https://doi.org/10.1042/CS20201372

Bibtex

@article{50fdc2655efb432d9e9d3aaedadea372,
title = "CRIP1 expression in monocytes related to hypertension",
abstract = "Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related genetic factors and is a risk factor for stroke, ischemic heart disease and renal failure. Although circulating monocytes and tissue macrophages contribute to the pathogenesis of hypertension, the underlying mechanisms are poorly understood. Cysteine rich protein 1 (CRIP1) is highly expressed in immune cells, and CRIP1 mRNA expression in monocytes associates with blood pressure (BP) and is up-regulated by proinflammatory modulation suggesting a link between CRIP1 and BP regulation through the immune system. To address this functional link, we studied CRIP1 expression in immune cells in relation to BP using a human cohort study and hypertensive mouse models. CRIP1 expression in splenic monocytes/macrophages and in circulating monocytes was significantly affected by angiotensin II (Ang II) in a BP-elevating dose (2 mg/kg/day). In the human cohort study, monocytic CRIP1 expression levels were associated with elevated BP, whereas upon differentiation of monocytes to macrophages this association along with the CRIP1 expression level was diminished. In conclusion, CRIP1-positive circulating and splenic monocytes seem to play an important role in hypertension related inflammatory processes through endogenous hormones such as Ang II. These findings suggest that CRIP1 may affect the interaction between the immune system, in particular monocytes, and the pathogenesis of hypertension.",
keywords = "Angiotensin II/administration & dosage, Animals, Blood Pressure, Carrier Proteins/genetics, Cell Differentiation, Cohort Studies, Disease Models, Animal, Humans, Hypertension/chemically induced, Macrophages, Male, Monocytes/metabolism, NG-Nitroarginine Methyl Ester/administration & dosage, Spleen, Transcriptome",
author = "Olga Schweigert and Julia Adler and Natalie L{\"a}ngst and Dylan A{\"i}ssi and {Duque Escobar}, Jorge and Teng Tong and Christian M{\"u}ller and David-Alexandre Tr{\'e}gou{\"e}t and Robert Lukowski and Tanja Zeller",
note = "{\textcopyright} 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.",
year = "2021",
month = apr,
day = "16",
doi = "10.1042/CS20201372",
language = "English",
volume = "135",
pages = "911--924",
journal = "CLIN SCI",
issn = "0143-5221",
publisher = "PORTLAND PRESS LTD",
number = "7",

}

RIS

TY - JOUR

T1 - CRIP1 expression in monocytes related to hypertension

AU - Schweigert, Olga

AU - Adler, Julia

AU - Längst, Natalie

AU - Aïssi, Dylan

AU - Duque Escobar, Jorge

AU - Tong, Teng

AU - Müller, Christian

AU - Trégouët, David-Alexandre

AU - Lukowski, Robert

AU - Zeller, Tanja

N1 - © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

PY - 2021/4/16

Y1 - 2021/4/16

N2 - Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related genetic factors and is a risk factor for stroke, ischemic heart disease and renal failure. Although circulating monocytes and tissue macrophages contribute to the pathogenesis of hypertension, the underlying mechanisms are poorly understood. Cysteine rich protein 1 (CRIP1) is highly expressed in immune cells, and CRIP1 mRNA expression in monocytes associates with blood pressure (BP) and is up-regulated by proinflammatory modulation suggesting a link between CRIP1 and BP regulation through the immune system. To address this functional link, we studied CRIP1 expression in immune cells in relation to BP using a human cohort study and hypertensive mouse models. CRIP1 expression in splenic monocytes/macrophages and in circulating monocytes was significantly affected by angiotensin II (Ang II) in a BP-elevating dose (2 mg/kg/day). In the human cohort study, monocytic CRIP1 expression levels were associated with elevated BP, whereas upon differentiation of monocytes to macrophages this association along with the CRIP1 expression level was diminished. In conclusion, CRIP1-positive circulating and splenic monocytes seem to play an important role in hypertension related inflammatory processes through endogenous hormones such as Ang II. These findings suggest that CRIP1 may affect the interaction between the immune system, in particular monocytes, and the pathogenesis of hypertension.

AB - Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related genetic factors and is a risk factor for stroke, ischemic heart disease and renal failure. Although circulating monocytes and tissue macrophages contribute to the pathogenesis of hypertension, the underlying mechanisms are poorly understood. Cysteine rich protein 1 (CRIP1) is highly expressed in immune cells, and CRIP1 mRNA expression in monocytes associates with blood pressure (BP) and is up-regulated by proinflammatory modulation suggesting a link between CRIP1 and BP regulation through the immune system. To address this functional link, we studied CRIP1 expression in immune cells in relation to BP using a human cohort study and hypertensive mouse models. CRIP1 expression in splenic monocytes/macrophages and in circulating monocytes was significantly affected by angiotensin II (Ang II) in a BP-elevating dose (2 mg/kg/day). In the human cohort study, monocytic CRIP1 expression levels were associated with elevated BP, whereas upon differentiation of monocytes to macrophages this association along with the CRIP1 expression level was diminished. In conclusion, CRIP1-positive circulating and splenic monocytes seem to play an important role in hypertension related inflammatory processes through endogenous hormones such as Ang II. These findings suggest that CRIP1 may affect the interaction between the immune system, in particular monocytes, and the pathogenesis of hypertension.

KW - Angiotensin II/administration & dosage

KW - Animals

KW - Blood Pressure

KW - Carrier Proteins/genetics

KW - Cell Differentiation

KW - Cohort Studies

KW - Disease Models, Animal

KW - Humans

KW - Hypertension/chemically induced

KW - Macrophages

KW - Male

KW - Monocytes/metabolism

KW - NG-Nitroarginine Methyl Ester/administration & dosage

KW - Spleen

KW - Transcriptome

U2 - 10.1042/CS20201372

DO - 10.1042/CS20201372

M3 - SCORING: Journal article

C2 - 33782695

VL - 135

SP - 911

EP - 924

JO - CLIN SCI

JF - CLIN SCI

SN - 0143-5221

IS - 7

ER -