CRIP1 expression in monocytes related to hypertension
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CRIP1 expression in monocytes related to hypertension. / Schweigert, Olga; Adler, Julia; Längst, Natalie; Aïssi, Dylan; Duque Escobar, Jorge; Tong, Teng; Müller, Christian; Trégouët, David-Alexandre; Lukowski, Robert; Zeller, Tanja.
in: CLIN SCI, Jahrgang 135, Nr. 7, 16.04.2021, S. 911-924.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - CRIP1 expression in monocytes related to hypertension
AU - Schweigert, Olga
AU - Adler, Julia
AU - Längst, Natalie
AU - Aïssi, Dylan
AU - Duque Escobar, Jorge
AU - Tong, Teng
AU - Müller, Christian
AU - Trégouët, David-Alexandre
AU - Lukowski, Robert
AU - Zeller, Tanja
N1 - © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
PY - 2021/4/16
Y1 - 2021/4/16
N2 - Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related genetic factors and is a risk factor for stroke, ischemic heart disease and renal failure. Although circulating monocytes and tissue macrophages contribute to the pathogenesis of hypertension, the underlying mechanisms are poorly understood. Cysteine rich protein 1 (CRIP1) is highly expressed in immune cells, and CRIP1 mRNA expression in monocytes associates with blood pressure (BP) and is up-regulated by proinflammatory modulation suggesting a link between CRIP1 and BP regulation through the immune system. To address this functional link, we studied CRIP1 expression in immune cells in relation to BP using a human cohort study and hypertensive mouse models. CRIP1 expression in splenic monocytes/macrophages and in circulating monocytes was significantly affected by angiotensin II (Ang II) in a BP-elevating dose (2 mg/kg/day). In the human cohort study, monocytic CRIP1 expression levels were associated with elevated BP, whereas upon differentiation of monocytes to macrophages this association along with the CRIP1 expression level was diminished. In conclusion, CRIP1-positive circulating and splenic monocytes seem to play an important role in hypertension related inflammatory processes through endogenous hormones such as Ang II. These findings suggest that CRIP1 may affect the interaction between the immune system, in particular monocytes, and the pathogenesis of hypertension.
AB - Hypertension is a complex and multifactorial disorder caused by lifestyle and environmental factors, inflammation and disease-related genetic factors and is a risk factor for stroke, ischemic heart disease and renal failure. Although circulating monocytes and tissue macrophages contribute to the pathogenesis of hypertension, the underlying mechanisms are poorly understood. Cysteine rich protein 1 (CRIP1) is highly expressed in immune cells, and CRIP1 mRNA expression in monocytes associates with blood pressure (BP) and is up-regulated by proinflammatory modulation suggesting a link between CRIP1 and BP regulation through the immune system. To address this functional link, we studied CRIP1 expression in immune cells in relation to BP using a human cohort study and hypertensive mouse models. CRIP1 expression in splenic monocytes/macrophages and in circulating monocytes was significantly affected by angiotensin II (Ang II) in a BP-elevating dose (2 mg/kg/day). In the human cohort study, monocytic CRIP1 expression levels were associated with elevated BP, whereas upon differentiation of monocytes to macrophages this association along with the CRIP1 expression level was diminished. In conclusion, CRIP1-positive circulating and splenic monocytes seem to play an important role in hypertension related inflammatory processes through endogenous hormones such as Ang II. These findings suggest that CRIP1 may affect the interaction between the immune system, in particular monocytes, and the pathogenesis of hypertension.
KW - Angiotensin II/administration & dosage
KW - Animals
KW - Blood Pressure
KW - Carrier Proteins/genetics
KW - Cell Differentiation
KW - Cohort Studies
KW - Disease Models, Animal
KW - Humans
KW - Hypertension/chemically induced
KW - Macrophages
KW - Male
KW - Monocytes/metabolism
KW - NG-Nitroarginine Methyl Ester/administration & dosage
KW - Spleen
KW - Transcriptome
U2 - 10.1042/CS20201372
DO - 10.1042/CS20201372
M3 - SCORING: Journal article
C2 - 33782695
VL - 135
SP - 911
EP - 924
JO - CLIN SCI
JF - CLIN SCI
SN - 0143-5221
IS - 7
ER -