C-reactive protein is not a screening tool for late periprosthetic joint infection
Standard
C-reactive protein is not a screening tool for late periprosthetic joint infection. / Fink, Bernd; Schlumberger, Michael; Beyersdorff, Julian; Schuster, Philipp.
In: J ORTHOP TRAUMATOL, Vol. 21, No. 1, 24.02.2020, p. 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - C-reactive protein is not a screening tool for late periprosthetic joint infection
AU - Fink, Bernd
AU - Schlumberger, Michael
AU - Beyersdorff, Julian
AU - Schuster, Philipp
PY - 2020/2/24
Y1 - 2020/2/24
N2 - BACKGROUND: Preoperative diagnosis of periprosthetic joint infection (PJI) is important because of the therapeutic consequences. The aim of the present study is to investigate whether the serum C-reactive protein (CRP) level can be used as a screening tool for late PJI.MATERIALS AND METHODS: A cohort of 390 patients with revision surgery of total hip prostheses (200) or total knee prostheses (190) was assessed for late PJI by determining CRP serum level and performing preoperative aspiration with cultivation and intraoperative tissue analyses with cultivation and histologic examination, using the Musculoskeletal Infection Society (MSIS) and International Consensus Meeting (ICM) criteria.RESULTS: A total of 180 joints were rated as PJI (prevalence 46%). Of these, 42.8% (77) showed a CRP level below 10 mg/L and 28.3% (51) showed a normal CRP level of less than 5 mg/L. The 76.9% of the cases with slow-growing bacteria showed a CRP level below 10 mg/L, and 61.5% showed a normal CRP level.CONCLUSIONS: Serum CRP level should not be used as a screening tool to rule out late PJI.LEVEL OF EVIDENCE: Level 2 (diagnostic study).
AB - BACKGROUND: Preoperative diagnosis of periprosthetic joint infection (PJI) is important because of the therapeutic consequences. The aim of the present study is to investigate whether the serum C-reactive protein (CRP) level can be used as a screening tool for late PJI.MATERIALS AND METHODS: A cohort of 390 patients with revision surgery of total hip prostheses (200) or total knee prostheses (190) was assessed for late PJI by determining CRP serum level and performing preoperative aspiration with cultivation and intraoperative tissue analyses with cultivation and histologic examination, using the Musculoskeletal Infection Society (MSIS) and International Consensus Meeting (ICM) criteria.RESULTS: A total of 180 joints were rated as PJI (prevalence 46%). Of these, 42.8% (77) showed a CRP level below 10 mg/L and 28.3% (51) showed a normal CRP level of less than 5 mg/L. The 76.9% of the cases with slow-growing bacteria showed a CRP level below 10 mg/L, and 61.5% showed a normal CRP level.CONCLUSIONS: Serum CRP level should not be used as a screening tool to rule out late PJI.LEVEL OF EVIDENCE: Level 2 (diagnostic study).
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Arthritis, Infectious/blood
KW - Arthroplasty, Replacement, Hip/adverse effects
KW - Arthroplasty, Replacement, Knee/adverse effects
KW - Biomarkers/blood
KW - C-Reactive Protein/metabolism
KW - Female
KW - Humans
KW - Knee Prosthesis/adverse effects
KW - Male
KW - Middle Aged
KW - Prosthesis-Related Infections/blood
U2 - 10.1186/s10195-020-0542-2
DO - 10.1186/s10195-020-0542-2
M3 - SCORING: Journal article
C2 - 32095896
VL - 21
SP - 2
JO - J ORTHOP TRAUMATOL
JF - J ORTHOP TRAUMATOL
SN - 1590-9921
IS - 1
ER -