COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas
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COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. / Armentano, Maria; Chou, Shen-Ju; Tomassy, Giulio Srubek; Leingärtner, Axel; O'Leary, Dennis D M; Studer, Michèle.
In: NAT NEUROSCI, Vol. 10, No. 10, 01.10.2007, p. 1277-86.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas
AU - Armentano, Maria
AU - Chou, Shen-Ju
AU - Tomassy, Giulio Srubek
AU - Leingärtner, Axel
AU - O'Leary, Dennis D M
AU - Studer, Michèle
PY - 2007/10/1
Y1 - 2007/10/1
N2 - We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.
AB - We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.
KW - Animals
KW - Body Patterning
KW - COUP Transcription Factor I
KW - Embryo, Mammalian
KW - Fibroblast Growth Factor 8
KW - Gene Expression Regulation, Developmental
KW - Homeodomain Proteins
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Transgenic
KW - Motor Cortex
KW - Neural Pathways
KW - PAX2 Transcription Factor
KW - Serotonin
KW - Somatosensory Cortex
KW - Transcription Factors
U2 - 10.1038/nn1958
DO - 10.1038/nn1958
M3 - SCORING: Journal article
C2 - 17828260
VL - 10
SP - 1277
EP - 1286
JO - NAT NEUROSCI
JF - NAT NEUROSCI
SN - 1097-6256
IS - 10
ER -