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COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas

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COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. / Armentano, Maria; Chou, Shen-Ju; Tomassy, Giulio Srubek; Leingärtner, Axel; O'Leary, Dennis D M; Studer, Michèle.

in: NAT NEUROSCI, Jahrgang 10, Nr. 10, 01.10.2007, S. 1277-86.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Armentano, M, Chou, S-J, Tomassy, GS, Leingärtner, A, O'Leary, DDM & Studer, M 2007, 'COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas', NAT NEUROSCI, Jg. 10, Nr. 10, S. 1277-86. https://doi.org/10.1038/nn1958

APA

Armentano, M., Chou, S-J., Tomassy, G. S., Leingärtner, A., O'Leary, D. D. M., & Studer, M. (2007). COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. NAT NEUROSCI, 10(10), 1277-86. https://doi.org/10.1038/nn1958

Vancouver

Armentano M, Chou S-J, Tomassy GS, Leingärtner A, O'Leary DDM, Studer M. COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. NAT NEUROSCI. 2007 Okt 1;10(10):1277-86. https://doi.org/10.1038/nn1958

Bibtex

@article{d436b881920747ba8d2420f175904c27,
title = "COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas",
abstract = "We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.",
keywords = "Animals, Body Patterning, COUP Transcription Factor I, Embryo, Mammalian, Fibroblast Growth Factor 8, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Cortex, Neural Pathways, PAX2 Transcription Factor, Serotonin, Somatosensory Cortex, Transcription Factors",
author = "Maria Armentano and Shen-Ju Chou and Tomassy, {Giulio Srubek} and Axel Leing{\"a}rtner and O'Leary, {Dennis D M} and Mich{\`e}le Studer",
year = "2007",
month = oct,
day = "1",
doi = "10.1038/nn1958",
language = "English",
volume = "10",
pages = "1277--86",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas

AU - Armentano, Maria

AU - Chou, Shen-Ju

AU - Tomassy, Giulio Srubek

AU - Leingärtner, Axel

AU - O'Leary, Dennis D M

AU - Studer, Michèle

PY - 2007/10/1

Y1 - 2007/10/1

N2 - We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.

AB - We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.

KW - Animals

KW - Body Patterning

KW - COUP Transcription Factor I

KW - Embryo, Mammalian

KW - Fibroblast Growth Factor 8

KW - Gene Expression Regulation, Developmental

KW - Homeodomain Proteins

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Motor Cortex

KW - Neural Pathways

KW - PAX2 Transcription Factor

KW - Serotonin

KW - Somatosensory Cortex

KW - Transcription Factors

U2 - 10.1038/nn1958

DO - 10.1038/nn1958

M3 - SCORING: Journal article

C2 - 17828260

VL - 10

SP - 1277

EP - 1286

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 10

ER -