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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. / Askew, Katharine; Li, Kaizhen; Olmos-Alonso, Adrian; Garcia-Moreno, Fernando; Liang, Yajie; Richardson, Philippa; Tipton, Tom; Chapman, Mark A; Riecken, Kristoffer; Beccari, Sol; Sierra, Amanda; Molnár, Zoltán; Cragg, Mark S; Garaschuk, Olga; Perry, V Hugh; Gomez-Nicola, Diego.

In: CELL REP, Vol. 18, No. 2, 10.01.2017, p. 391-405.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Askew, K, Li, K, Olmos-Alonso, A, Garcia-Moreno, F, Liang, Y, Richardson, P, Tipton, T, Chapman, MA, Riecken, K, Beccari, S, Sierra, A, Molnár, Z, Cragg, MS, Garaschuk, O, Perry, VH & Gomez-Nicola, D 2017, 'Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain', CELL REP, vol. 18, no. 2, pp. 391-405. https://doi.org/10.1016/j.celrep.2016.12.041

APA

Askew, K., Li, K., Olmos-Alonso, A., Garcia-Moreno, F., Liang, Y., Richardson, P., Tipton, T., Chapman, M. A., Riecken, K., Beccari, S., Sierra, A., Molnár, Z., Cragg, M. S., Garaschuk, O., Perry, V. H., & Gomez-Nicola, D. (2017). Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. CELL REP, 18(2), 391-405. https://doi.org/10.1016/j.celrep.2016.12.041

Vancouver

Askew K, Li K, Olmos-Alonso A, Garcia-Moreno F, Liang Y, Richardson P et al. Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. CELL REP. 2017 Jan 10;18(2):391-405. https://doi.org/10.1016/j.celrep.2016.12.041

Bibtex

@article{5204143ff30a40858f732fa12a0a618e,
title = "Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain",
abstract = "Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.",
author = "Katharine Askew and Kaizhen Li and Adrian Olmos-Alonso and Fernando Garcia-Moreno and Yajie Liang and Philippa Richardson and Tom Tipton and Chapman, {Mark A} and Kristoffer Riecken and Sol Beccari and Amanda Sierra and Zolt{\'a}n Moln{\'a}r and Cragg, {Mark S} and Olga Garaschuk and Perry, {V Hugh} and Diego Gomez-Nicola",
note = "Copyright {\textcopyright} 2017 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = jan,
day = "10",
doi = "10.1016/j.celrep.2016.12.041",
language = "English",
volume = "18",
pages = "391--405",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

AU - Askew, Katharine

AU - Li, Kaizhen

AU - Olmos-Alonso, Adrian

AU - Garcia-Moreno, Fernando

AU - Liang, Yajie

AU - Richardson, Philippa

AU - Tipton, Tom

AU - Chapman, Mark A

AU - Riecken, Kristoffer

AU - Beccari, Sol

AU - Sierra, Amanda

AU - Molnár, Zoltán

AU - Cragg, Mark S

AU - Garaschuk, Olga

AU - Perry, V Hugh

AU - Gomez-Nicola, Diego

N1 - Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2017/1/10

Y1 - 2017/1/10

N2 - Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.

AB - Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.

U2 - 10.1016/j.celrep.2016.12.041

DO - 10.1016/j.celrep.2016.12.041

M3 - SCORING: Journal article

C2 - 28076784

VL - 18

SP - 391

EP - 405

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 2

ER -