Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. / Askew, Katharine; Li, Kaizhen; Olmos-Alonso, Adrian; Garcia-Moreno, Fernando; Liang, Yajie; Richardson, Philippa; Tipton, Tom; Chapman, Mark A; Riecken, Kristoffer; Beccari, Sol; Sierra, Amanda; Molnár, Zoltán; Cragg, Mark S; Garaschuk, Olga; Perry, V Hugh; Gomez-Nicola, Diego.
in: CELL REP, Jahrgang 18, Nr. 2, 10.01.2017, S. 391-405.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
AU - Askew, Katharine
AU - Li, Kaizhen
AU - Olmos-Alonso, Adrian
AU - Garcia-Moreno, Fernando
AU - Liang, Yajie
AU - Richardson, Philippa
AU - Tipton, Tom
AU - Chapman, Mark A
AU - Riecken, Kristoffer
AU - Beccari, Sol
AU - Sierra, Amanda
AU - Molnár, Zoltán
AU - Cragg, Mark S
AU - Garaschuk, Olga
AU - Perry, V Hugh
AU - Gomez-Nicola, Diego
N1 - Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2017/1/10
Y1 - 2017/1/10
N2 - Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.
AB - Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.
U2 - 10.1016/j.celrep.2016.12.041
DO - 10.1016/j.celrep.2016.12.041
M3 - SCORING: Journal article
C2 - 28076784
VL - 18
SP - 391
EP - 405
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 2
ER -