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Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence

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Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence. / Schilling, C; Kühn, S; Paus, T; Romanowski, A; Banaschewski, T; Barbot, A; Barker, G J; Brühl, R; Büchel, C; Conrod, P J; Dalley, J W; Flor, H; Ittermann, B; Ivanov, N; Mann, K; Martinot, J-L; Nees, F; Rietschel, M; Robbins, T W; Smolka, M N; Ströhle, A; Kathmann, N; Garavan, H; Heinz, A; Schumann, G; Gallinat, Jürgen; IMAGEN Consortium.

In: MOL PSYCHIATR, Vol. 18, No. 5, 01.05.2013, p. 624-30.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schilling, C, Kühn, S, Paus, T, Romanowski, A, Banaschewski, T, Barbot, A, Barker, GJ, Brühl, R, Büchel, C, Conrod, PJ, Dalley, JW, Flor, H, Ittermann, B, Ivanov, N, Mann, K, Martinot, J-L, Nees, F, Rietschel, M, Robbins, TW, Smolka, MN, Ströhle, A, Kathmann, N, Garavan, H, Heinz, A, Schumann, G, Gallinat, J & IMAGEN Consortium 2013, 'Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence', MOL PSYCHIATR, vol. 18, no. 5, pp. 624-30. https://doi.org/10.1038/mp.2012.56

APA

Schilling, C., Kühn, S., Paus, T., Romanowski, A., Banaschewski, T., Barbot, A., Barker, G. J., Brühl, R., Büchel, C., Conrod, P. J., Dalley, J. W., Flor, H., Ittermann, B., Ivanov, N., Mann, K., Martinot, J-L., Nees, F., Rietschel, M., Robbins, T. W., ... IMAGEN Consortium (2013). Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence. MOL PSYCHIATR, 18(5), 624-30. https://doi.org/10.1038/mp.2012.56

Vancouver

Schilling C, Kühn S, Paus T, Romanowski A, Banaschewski T, Barbot A et al. Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence. MOL PSYCHIATR. 2013 May 1;18(5):624-30. https://doi.org/10.1038/mp.2012.56

Bibtex

@article{3a44e0091dbc4c58b3ab8c163448c517,
title = "Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence",
abstract = "Impulsiveness is a pivotal personality trait representing a core domain in all major personality inventories. Recently, impulsiveness has been identified as an important modulator of cognitive processing, particularly in tasks that require the processing of large amounts of information. Although brain imaging studies have implicated the prefrontal cortex to be a common underlying representation of impulsiveness and related cognitive functioning, to date a fine-grain and detailed morphometric analysis has not been carried out. On the basis of ahigh-resolution magnetic resonance scans acquired in 1620 healthy adolescents (IMAGEN), the individual cortical thickness (CT) was estimated. Correlations between Cloninger's impulsiveness and CT were studied in an entire cortex analysis. The cluster identified was tested for associations with performance in perceptual reasoning tasks of the Wechsler Intelligence Scale for Children (WISC IV). We observed a significant inverse correlation between trait impulsiveness and CT of the left superior frontal cortex (SFC; Monte Carlo Simulation P<0.01). CT within this cluster correlated with perceptual reasoning scores (Bonferroni corrected) of the WISC IV. On the basis of a large sample of adolescents, we identified an extended area in the SFC as a correlate of impulsiveness, which appears to be in line with the trait character of this prominent personality facet. The association of SFC thickness with perceptual reasoning argues for a common neurobiological basis of personality and specific cognitive domains comprising attention, spatial reasoning and response selection. The results may facilitate the understanding of the role of impulsiveness in several psychiatric disorders associated with prefrontal dysfunctions and cognitive deficits.",
keywords = "Adolescent, Brain Mapping, Europe, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, International Classification of Diseases, Male, Mental Processes, Neuropsychological Tests, Perception, Personality Tests, Prefrontal Cortex, Psychiatric Status Rating Scales",
author = "C Schilling and S K{\"u}hn and T Paus and A Romanowski and T Banaschewski and A Barbot and Barker, {G J} and R Br{\"u}hl and C B{\"u}chel and Conrod, {P J} and Dalley, {J W} and H Flor and B Ittermann and N Ivanov and K Mann and J-L Martinot and F Nees and M Rietschel and Robbins, {T W} and Smolka, {M N} and A Str{\"o}hle and N Kathmann and H Garavan and A Heinz and G Schumann and J{\"u}rgen Gallinat and {IMAGEN Consortium}",
year = "2013",
month = may,
day = "1",
doi = "10.1038/mp.2012.56",
language = "English",
volume = "18",
pages = "624--30",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence

AU - Schilling, C

AU - Kühn, S

AU - Paus, T

AU - Romanowski, A

AU - Banaschewski, T

AU - Barbot, A

AU - Barker, G J

AU - Brühl, R

AU - Büchel, C

AU - Conrod, P J

AU - Dalley, J W

AU - Flor, H

AU - Ittermann, B

AU - Ivanov, N

AU - Mann, K

AU - Martinot, J-L

AU - Nees, F

AU - Rietschel, M

AU - Robbins, T W

AU - Smolka, M N

AU - Ströhle, A

AU - Kathmann, N

AU - Garavan, H

AU - Heinz, A

AU - Schumann, G

AU - Gallinat, Jürgen

AU - IMAGEN Consortium

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Impulsiveness is a pivotal personality trait representing a core domain in all major personality inventories. Recently, impulsiveness has been identified as an important modulator of cognitive processing, particularly in tasks that require the processing of large amounts of information. Although brain imaging studies have implicated the prefrontal cortex to be a common underlying representation of impulsiveness and related cognitive functioning, to date a fine-grain and detailed morphometric analysis has not been carried out. On the basis of ahigh-resolution magnetic resonance scans acquired in 1620 healthy adolescents (IMAGEN), the individual cortical thickness (CT) was estimated. Correlations between Cloninger's impulsiveness and CT were studied in an entire cortex analysis. The cluster identified was tested for associations with performance in perceptual reasoning tasks of the Wechsler Intelligence Scale for Children (WISC IV). We observed a significant inverse correlation between trait impulsiveness and CT of the left superior frontal cortex (SFC; Monte Carlo Simulation P<0.01). CT within this cluster correlated with perceptual reasoning scores (Bonferroni corrected) of the WISC IV. On the basis of a large sample of adolescents, we identified an extended area in the SFC as a correlate of impulsiveness, which appears to be in line with the trait character of this prominent personality facet. The association of SFC thickness with perceptual reasoning argues for a common neurobiological basis of personality and specific cognitive domains comprising attention, spatial reasoning and response selection. The results may facilitate the understanding of the role of impulsiveness in several psychiatric disorders associated with prefrontal dysfunctions and cognitive deficits.

AB - Impulsiveness is a pivotal personality trait representing a core domain in all major personality inventories. Recently, impulsiveness has been identified as an important modulator of cognitive processing, particularly in tasks that require the processing of large amounts of information. Although brain imaging studies have implicated the prefrontal cortex to be a common underlying representation of impulsiveness and related cognitive functioning, to date a fine-grain and detailed morphometric analysis has not been carried out. On the basis of ahigh-resolution magnetic resonance scans acquired in 1620 healthy adolescents (IMAGEN), the individual cortical thickness (CT) was estimated. Correlations between Cloninger's impulsiveness and CT were studied in an entire cortex analysis. The cluster identified was tested for associations with performance in perceptual reasoning tasks of the Wechsler Intelligence Scale for Children (WISC IV). We observed a significant inverse correlation between trait impulsiveness and CT of the left superior frontal cortex (SFC; Monte Carlo Simulation P<0.01). CT within this cluster correlated with perceptual reasoning scores (Bonferroni corrected) of the WISC IV. On the basis of a large sample of adolescents, we identified an extended area in the SFC as a correlate of impulsiveness, which appears to be in line with the trait character of this prominent personality facet. The association of SFC thickness with perceptual reasoning argues for a common neurobiological basis of personality and specific cognitive domains comprising attention, spatial reasoning and response selection. The results may facilitate the understanding of the role of impulsiveness in several psychiatric disorders associated with prefrontal dysfunctions and cognitive deficits.

KW - Adolescent

KW - Brain Mapping

KW - Europe

KW - Female

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Impulsive Behavior

KW - International Classification of Diseases

KW - Male

KW - Mental Processes

KW - Neuropsychological Tests

KW - Perception

KW - Personality Tests

KW - Prefrontal Cortex

KW - Psychiatric Status Rating Scales

U2 - 10.1038/mp.2012.56

DO - 10.1038/mp.2012.56

M3 - SCORING: Journal article

C2 - 22665261

VL - 18

SP - 624

EP - 630

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

IS - 5

ER -