Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence
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Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence. / Schilling, C; Kühn, S; Paus, T; Romanowski, A; Banaschewski, T; Barbot, A; Barker, G J; Brühl, R; Büchel, C; Conrod, P J; Dalley, J W; Flor, H; Ittermann, B; Ivanov, N; Mann, K; Martinot, J-L; Nees, F; Rietschel, M; Robbins, T W; Smolka, M N; Ströhle, A; Kathmann, N; Garavan, H; Heinz, A; Schumann, G; Gallinat, Jürgen; IMAGEN Consortium.
in: MOL PSYCHIATR, Jahrgang 18, Nr. 5, 01.05.2013, S. 624-30.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence
AU - Schilling, C
AU - Kühn, S
AU - Paus, T
AU - Romanowski, A
AU - Banaschewski, T
AU - Barbot, A
AU - Barker, G J
AU - Brühl, R
AU - Büchel, C
AU - Conrod, P J
AU - Dalley, J W
AU - Flor, H
AU - Ittermann, B
AU - Ivanov, N
AU - Mann, K
AU - Martinot, J-L
AU - Nees, F
AU - Rietschel, M
AU - Robbins, T W
AU - Smolka, M N
AU - Ströhle, A
AU - Kathmann, N
AU - Garavan, H
AU - Heinz, A
AU - Schumann, G
AU - Gallinat, Jürgen
AU - IMAGEN Consortium
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Impulsiveness is a pivotal personality trait representing a core domain in all major personality inventories. Recently, impulsiveness has been identified as an important modulator of cognitive processing, particularly in tasks that require the processing of large amounts of information. Although brain imaging studies have implicated the prefrontal cortex to be a common underlying representation of impulsiveness and related cognitive functioning, to date a fine-grain and detailed morphometric analysis has not been carried out. On the basis of ahigh-resolution magnetic resonance scans acquired in 1620 healthy adolescents (IMAGEN), the individual cortical thickness (CT) was estimated. Correlations between Cloninger's impulsiveness and CT were studied in an entire cortex analysis. The cluster identified was tested for associations with performance in perceptual reasoning tasks of the Wechsler Intelligence Scale for Children (WISC IV). We observed a significant inverse correlation between trait impulsiveness and CT of the left superior frontal cortex (SFC; Monte Carlo Simulation P<0.01). CT within this cluster correlated with perceptual reasoning scores (Bonferroni corrected) of the WISC IV. On the basis of a large sample of adolescents, we identified an extended area in the SFC as a correlate of impulsiveness, which appears to be in line with the trait character of this prominent personality facet. The association of SFC thickness with perceptual reasoning argues for a common neurobiological basis of personality and specific cognitive domains comprising attention, spatial reasoning and response selection. The results may facilitate the understanding of the role of impulsiveness in several psychiatric disorders associated with prefrontal dysfunctions and cognitive deficits.
AB - Impulsiveness is a pivotal personality trait representing a core domain in all major personality inventories. Recently, impulsiveness has been identified as an important modulator of cognitive processing, particularly in tasks that require the processing of large amounts of information. Although brain imaging studies have implicated the prefrontal cortex to be a common underlying representation of impulsiveness and related cognitive functioning, to date a fine-grain and detailed morphometric analysis has not been carried out. On the basis of ahigh-resolution magnetic resonance scans acquired in 1620 healthy adolescents (IMAGEN), the individual cortical thickness (CT) was estimated. Correlations between Cloninger's impulsiveness and CT were studied in an entire cortex analysis. The cluster identified was tested for associations with performance in perceptual reasoning tasks of the Wechsler Intelligence Scale for Children (WISC IV). We observed a significant inverse correlation between trait impulsiveness and CT of the left superior frontal cortex (SFC; Monte Carlo Simulation P<0.01). CT within this cluster correlated with perceptual reasoning scores (Bonferroni corrected) of the WISC IV. On the basis of a large sample of adolescents, we identified an extended area in the SFC as a correlate of impulsiveness, which appears to be in line with the trait character of this prominent personality facet. The association of SFC thickness with perceptual reasoning argues for a common neurobiological basis of personality and specific cognitive domains comprising attention, spatial reasoning and response selection. The results may facilitate the understanding of the role of impulsiveness in several psychiatric disorders associated with prefrontal dysfunctions and cognitive deficits.
KW - Adolescent
KW - Brain Mapping
KW - Europe
KW - Female
KW - Functional Laterality
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Impulsive Behavior
KW - International Classification of Diseases
KW - Male
KW - Mental Processes
KW - Neuropsychological Tests
KW - Perception
KW - Personality Tests
KW - Prefrontal Cortex
KW - Psychiatric Status Rating Scales
U2 - 10.1038/mp.2012.56
DO - 10.1038/mp.2012.56
M3 - SCORING: Journal article
C2 - 22665261
VL - 18
SP - 624
EP - 630
JO - MOL PSYCHIATR
JF - MOL PSYCHIATR
SN - 1359-4184
IS - 5
ER -