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Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions

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Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions. / Lorenz, Jürgen; Hauck, Michael; Paur, Robert C; Nakamura, Yoko; Zimmermann, Roger; Bromm, Burkhart; Engel, Andreas K.

In: BRAIN BEHAV IMMUN, Vol. 19, No. 4, 01.07.2005, p. 283-95.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lorenz, J, Hauck, M, Paur, RC, Nakamura, Y, Zimmermann, R, Bromm, B & Engel, AK 2005, 'Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions', BRAIN BEHAV IMMUN, vol. 19, no. 4, pp. 283-95. https://doi.org/10.1016/j.bbi.2005.03.010

APA

Lorenz, J., Hauck, M., Paur, R. C., Nakamura, Y., Zimmermann, R., Bromm, B., & Engel, A. K. (2005). Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions. BRAIN BEHAV IMMUN, 19(4), 283-95. https://doi.org/10.1016/j.bbi.2005.03.010

Vancouver

Lorenz J, Hauck M, Paur RC, Nakamura Y, Zimmermann R, Bromm B et al. Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions. BRAIN BEHAV IMMUN. 2005 Jul 1;19(4):283-95. https://doi.org/10.1016/j.bbi.2005.03.010

Bibtex

@article{f1e043cb43354bacb5536a0c2508952d,
title = "Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions",
abstract = "We investigated the effects of expectation on intensity ratings and somatosensory evoked magnetic fields and electrical potentials following painful infrared laser stimuli in six healthy subjects. The stimulus series contained trials preceded by different auditory cues which either contained valid, invalid or no information about the upcoming laser intensity. High and low intensities occurred equally probable across cue types. High intensity stimuli induced greater pain than low intensity across all cue types. Furthermore, laser intensity significantly interacted with cue validity: high intensity stimuli were perceived less painful and low intensity stimuli more painful following invalid compared to valid cues. The amplitude of the evoked magnetic field localized within the contralateral secondary somatosensory cortex (SII) at about 165 ms after laser stimuli varied also both with stimulus intensity and cue validity. The evoked electric potential peaked at about 300 ms after laser stimuli and yielded a single dipole source within a region encompassing the caudal anterior cingulate cortex and posterior cingulate cortex. Its amplitude also varied with stimulus intensity, but failed to show any cue validity effects. This result suggests a priming of early cortical nociceptive sensitivity by cues signaling pain severity. A possible contribution of the SII cortex to the manifestation of nocebo/placebo cognitions is discussed.",
keywords = "Acoustic Stimulation, Adult, Association Learning, Cues, Electroencephalography, Evoked Potentials, Somatosensory, Functional Laterality, Gyrus Cinguli, Humans, Judgment, Magnetoencephalography, Male, Nociceptors, Pain Measurement, Pain Threshold, Placebo Effect, Reference Values, Set (Psychology)",
author = "J{\"u}rgen Lorenz and Michael Hauck and Paur, {Robert C} and Yoko Nakamura and Roger Zimmermann and Burkhart Bromm and Engel, {Andreas K}",
year = "2005",
month = jul,
day = "1",
doi = "10.1016/j.bbi.2005.03.010",
language = "English",
volume = "19",
pages = "283--95",
journal = "BRAIN BEHAV IMMUN",
issn = "0889-1591",
publisher = "Academic Press Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions

AU - Lorenz, Jürgen

AU - Hauck, Michael

AU - Paur, Robert C

AU - Nakamura, Yoko

AU - Zimmermann, Roger

AU - Bromm, Burkhart

AU - Engel, Andreas K

PY - 2005/7/1

Y1 - 2005/7/1

N2 - We investigated the effects of expectation on intensity ratings and somatosensory evoked magnetic fields and electrical potentials following painful infrared laser stimuli in six healthy subjects. The stimulus series contained trials preceded by different auditory cues which either contained valid, invalid or no information about the upcoming laser intensity. High and low intensities occurred equally probable across cue types. High intensity stimuli induced greater pain than low intensity across all cue types. Furthermore, laser intensity significantly interacted with cue validity: high intensity stimuli were perceived less painful and low intensity stimuli more painful following invalid compared to valid cues. The amplitude of the evoked magnetic field localized within the contralateral secondary somatosensory cortex (SII) at about 165 ms after laser stimuli varied also both with stimulus intensity and cue validity. The evoked electric potential peaked at about 300 ms after laser stimuli and yielded a single dipole source within a region encompassing the caudal anterior cingulate cortex and posterior cingulate cortex. Its amplitude also varied with stimulus intensity, but failed to show any cue validity effects. This result suggests a priming of early cortical nociceptive sensitivity by cues signaling pain severity. A possible contribution of the SII cortex to the manifestation of nocebo/placebo cognitions is discussed.

AB - We investigated the effects of expectation on intensity ratings and somatosensory evoked magnetic fields and electrical potentials following painful infrared laser stimuli in six healthy subjects. The stimulus series contained trials preceded by different auditory cues which either contained valid, invalid or no information about the upcoming laser intensity. High and low intensities occurred equally probable across cue types. High intensity stimuli induced greater pain than low intensity across all cue types. Furthermore, laser intensity significantly interacted with cue validity: high intensity stimuli were perceived less painful and low intensity stimuli more painful following invalid compared to valid cues. The amplitude of the evoked magnetic field localized within the contralateral secondary somatosensory cortex (SII) at about 165 ms after laser stimuli varied also both with stimulus intensity and cue validity. The evoked electric potential peaked at about 300 ms after laser stimuli and yielded a single dipole source within a region encompassing the caudal anterior cingulate cortex and posterior cingulate cortex. Its amplitude also varied with stimulus intensity, but failed to show any cue validity effects. This result suggests a priming of early cortical nociceptive sensitivity by cues signaling pain severity. A possible contribution of the SII cortex to the manifestation of nocebo/placebo cognitions is discussed.

KW - Acoustic Stimulation

KW - Adult

KW - Association Learning

KW - Cues

KW - Electroencephalography

KW - Evoked Potentials, Somatosensory

KW - Functional Laterality

KW - Gyrus Cinguli

KW - Humans

KW - Judgment

KW - Magnetoencephalography

KW - Male

KW - Nociceptors

KW - Pain Measurement

KW - Pain Threshold

KW - Placebo Effect

KW - Reference Values

KW - Set (Psychology)

U2 - 10.1016/j.bbi.2005.03.010

DO - 10.1016/j.bbi.2005.03.010

M3 - SCORING: Journal article

C2 - 15890494

VL - 19

SP - 283

EP - 295

JO - BRAIN BEHAV IMMUN

JF - BRAIN BEHAV IMMUN

SN - 0889-1591

IS - 4

ER -