Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions
Standard
Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions. / Lorenz, Jürgen; Hauck, Michael; Paur, Robert C; Nakamura, Yoko; Zimmermann, Roger; Bromm, Burkhart; Engel, Andreas K.
in: BRAIN BEHAV IMMUN, Jahrgang 19, Nr. 4, 01.07.2005, S. 283-95.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Cortical correlates of false expectations during pain intensity judgments--a possible manifestation of placebo/nocebo cognitions
AU - Lorenz, Jürgen
AU - Hauck, Michael
AU - Paur, Robert C
AU - Nakamura, Yoko
AU - Zimmermann, Roger
AU - Bromm, Burkhart
AU - Engel, Andreas K
PY - 2005/7/1
Y1 - 2005/7/1
N2 - We investigated the effects of expectation on intensity ratings and somatosensory evoked magnetic fields and electrical potentials following painful infrared laser stimuli in six healthy subjects. The stimulus series contained trials preceded by different auditory cues which either contained valid, invalid or no information about the upcoming laser intensity. High and low intensities occurred equally probable across cue types. High intensity stimuli induced greater pain than low intensity across all cue types. Furthermore, laser intensity significantly interacted with cue validity: high intensity stimuli were perceived less painful and low intensity stimuli more painful following invalid compared to valid cues. The amplitude of the evoked magnetic field localized within the contralateral secondary somatosensory cortex (SII) at about 165 ms after laser stimuli varied also both with stimulus intensity and cue validity. The evoked electric potential peaked at about 300 ms after laser stimuli and yielded a single dipole source within a region encompassing the caudal anterior cingulate cortex and posterior cingulate cortex. Its amplitude also varied with stimulus intensity, but failed to show any cue validity effects. This result suggests a priming of early cortical nociceptive sensitivity by cues signaling pain severity. A possible contribution of the SII cortex to the manifestation of nocebo/placebo cognitions is discussed.
AB - We investigated the effects of expectation on intensity ratings and somatosensory evoked magnetic fields and electrical potentials following painful infrared laser stimuli in six healthy subjects. The stimulus series contained trials preceded by different auditory cues which either contained valid, invalid or no information about the upcoming laser intensity. High and low intensities occurred equally probable across cue types. High intensity stimuli induced greater pain than low intensity across all cue types. Furthermore, laser intensity significantly interacted with cue validity: high intensity stimuli were perceived less painful and low intensity stimuli more painful following invalid compared to valid cues. The amplitude of the evoked magnetic field localized within the contralateral secondary somatosensory cortex (SII) at about 165 ms after laser stimuli varied also both with stimulus intensity and cue validity. The evoked electric potential peaked at about 300 ms after laser stimuli and yielded a single dipole source within a region encompassing the caudal anterior cingulate cortex and posterior cingulate cortex. Its amplitude also varied with stimulus intensity, but failed to show any cue validity effects. This result suggests a priming of early cortical nociceptive sensitivity by cues signaling pain severity. A possible contribution of the SII cortex to the manifestation of nocebo/placebo cognitions is discussed.
KW - Acoustic Stimulation
KW - Adult
KW - Association Learning
KW - Cues
KW - Electroencephalography
KW - Evoked Potentials, Somatosensory
KW - Functional Laterality
KW - Gyrus Cinguli
KW - Humans
KW - Judgment
KW - Magnetoencephalography
KW - Male
KW - Nociceptors
KW - Pain Measurement
KW - Pain Threshold
KW - Placebo Effect
KW - Reference Values
KW - Set (Psychology)
U2 - 10.1016/j.bbi.2005.03.010
DO - 10.1016/j.bbi.2005.03.010
M3 - SCORING: Journal article
C2 - 15890494
VL - 19
SP - 283
EP - 295
JO - BRAIN BEHAV IMMUN
JF - BRAIN BEHAV IMMUN
SN - 0889-1591
IS - 4
ER -