Correlations enhance the behavioral readout of neural population activity in association cortex
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Correlations enhance the behavioral readout of neural population activity in association cortex. / Valente, Martina; Pica, Giuseppe; Bondanelli, Giulio; Moroni, Monica; Runyan, Caroline A; Morcos, Ari S; Harvey, Christopher D; Panzeri, Stefano.
In: NAT NEUROSCI, Vol. 24, No. 7, 07.2021, p. 975-986.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Correlations enhance the behavioral readout of neural population activity in association cortex
AU - Valente, Martina
AU - Pica, Giuseppe
AU - Bondanelli, Giulio
AU - Moroni, Monica
AU - Runyan, Caroline A
AU - Morcos, Ari S
AU - Harvey, Christopher D
AU - Panzeri, Stefano
PY - 2021/7
Y1 - 2021/7
N2 - Noise correlations (that is, trial-to-trial covariations in neural activity for a given stimulus) limit the stimulus information encoded by neural populations, leading to the widely held prediction that they impair perceptual discrimination behaviors. However, this prediction neglects the effects of correlations on information readout. We studied how correlations affect both encoding and readout of sensory information. We analyzed calcium imaging data from mouse posterior parietal cortex during two perceptual discrimination tasks. Correlations reduced the encoded stimulus information, but, seemingly paradoxically, were higher when mice made correct rather than incorrect choices. Single-trial behavioral choices depended not only on the stimulus information encoded by the whole population, but unexpectedly also on the consistency of information across neurons and time. Because correlations increased information consistency, they enhanced the conversion of sensory information into behavioral choices, overcoming their detrimental information-limiting effects. Thus, correlations in association cortex can benefit task performance even if they decrease sensory information.
AB - Noise correlations (that is, trial-to-trial covariations in neural activity for a given stimulus) limit the stimulus information encoded by neural populations, leading to the widely held prediction that they impair perceptual discrimination behaviors. However, this prediction neglects the effects of correlations on information readout. We studied how correlations affect both encoding and readout of sensory information. We analyzed calcium imaging data from mouse posterior parietal cortex during two perceptual discrimination tasks. Correlations reduced the encoded stimulus information, but, seemingly paradoxically, were higher when mice made correct rather than incorrect choices. Single-trial behavioral choices depended not only on the stimulus information encoded by the whole population, but unexpectedly also on the consistency of information across neurons and time. Because correlations increased information consistency, they enhanced the conversion of sensory information into behavioral choices, overcoming their detrimental information-limiting effects. Thus, correlations in association cortex can benefit task performance even if they decrease sensory information.
KW - Animals
KW - Choice Behavior/physiology
KW - Mice
KW - Models, Neurological
KW - Neurons/physiology
KW - Parietal Lobe/physiology
U2 - 10.1038/s41593-021-00845-1
DO - 10.1038/s41593-021-00845-1
M3 - SCORING: Journal article
C2 - 33986549
VL - 24
SP - 975
EP - 986
JO - NAT NEUROSCI
JF - NAT NEUROSCI
SN - 1097-6256
IS - 7
ER -