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Correlations enhance the behavioral readout of neural population activity in association cortex

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Correlations enhance the behavioral readout of neural population activity in association cortex. / Valente, Martina; Pica, Giuseppe; Bondanelli, Giulio; Moroni, Monica; Runyan, Caroline A; Morcos, Ari S; Harvey, Christopher D; Panzeri, Stefano.

in: NAT NEUROSCI, Jahrgang 24, Nr. 7, 07.2021, S. 975-986.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Valente, M, Pica, G, Bondanelli, G, Moroni, M, Runyan, CA, Morcos, AS, Harvey, CD & Panzeri, S 2021, 'Correlations enhance the behavioral readout of neural population activity in association cortex', NAT NEUROSCI, Jg. 24, Nr. 7, S. 975-986. https://doi.org/10.1038/s41593-021-00845-1

APA

Valente, M., Pica, G., Bondanelli, G., Moroni, M., Runyan, C. A., Morcos, A. S., Harvey, C. D., & Panzeri, S. (2021). Correlations enhance the behavioral readout of neural population activity in association cortex. NAT NEUROSCI, 24(7), 975-986. https://doi.org/10.1038/s41593-021-00845-1

Vancouver

Valente M, Pica G, Bondanelli G, Moroni M, Runyan CA, Morcos AS et al. Correlations enhance the behavioral readout of neural population activity in association cortex. NAT NEUROSCI. 2021 Jul;24(7):975-986. https://doi.org/10.1038/s41593-021-00845-1

Bibtex

@article{22f82189e2b2426b850e451ae3579c48,
title = "Correlations enhance the behavioral readout of neural population activity in association cortex",
abstract = "Noise correlations (that is, trial-to-trial covariations in neural activity for a given stimulus) limit the stimulus information encoded by neural populations, leading to the widely held prediction that they impair perceptual discrimination behaviors. However, this prediction neglects the effects of correlations on information readout. We studied how correlations affect both encoding and readout of sensory information. We analyzed calcium imaging data from mouse posterior parietal cortex during two perceptual discrimination tasks. Correlations reduced the encoded stimulus information, but, seemingly paradoxically, were higher when mice made correct rather than incorrect choices. Single-trial behavioral choices depended not only on the stimulus information encoded by the whole population, but unexpectedly also on the consistency of information across neurons and time. Because correlations increased information consistency, they enhanced the conversion of sensory information into behavioral choices, overcoming their detrimental information-limiting effects. Thus, correlations in association cortex can benefit task performance even if they decrease sensory information.",
keywords = "Animals, Choice Behavior/physiology, Mice, Models, Neurological, Neurons/physiology, Parietal Lobe/physiology",
author = "Martina Valente and Giuseppe Pica and Giulio Bondanelli and Monica Moroni and Runyan, {Caroline A} and Morcos, {Ari S} and Harvey, {Christopher D} and Stefano Panzeri",
year = "2021",
month = jul,
doi = "10.1038/s41593-021-00845-1",
language = "English",
volume = "24",
pages = "975--986",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Correlations enhance the behavioral readout of neural population activity in association cortex

AU - Valente, Martina

AU - Pica, Giuseppe

AU - Bondanelli, Giulio

AU - Moroni, Monica

AU - Runyan, Caroline A

AU - Morcos, Ari S

AU - Harvey, Christopher D

AU - Panzeri, Stefano

PY - 2021/7

Y1 - 2021/7

N2 - Noise correlations (that is, trial-to-trial covariations in neural activity for a given stimulus) limit the stimulus information encoded by neural populations, leading to the widely held prediction that they impair perceptual discrimination behaviors. However, this prediction neglects the effects of correlations on information readout. We studied how correlations affect both encoding and readout of sensory information. We analyzed calcium imaging data from mouse posterior parietal cortex during two perceptual discrimination tasks. Correlations reduced the encoded stimulus information, but, seemingly paradoxically, were higher when mice made correct rather than incorrect choices. Single-trial behavioral choices depended not only on the stimulus information encoded by the whole population, but unexpectedly also on the consistency of information across neurons and time. Because correlations increased information consistency, they enhanced the conversion of sensory information into behavioral choices, overcoming their detrimental information-limiting effects. Thus, correlations in association cortex can benefit task performance even if they decrease sensory information.

AB - Noise correlations (that is, trial-to-trial covariations in neural activity for a given stimulus) limit the stimulus information encoded by neural populations, leading to the widely held prediction that they impair perceptual discrimination behaviors. However, this prediction neglects the effects of correlations on information readout. We studied how correlations affect both encoding and readout of sensory information. We analyzed calcium imaging data from mouse posterior parietal cortex during two perceptual discrimination tasks. Correlations reduced the encoded stimulus information, but, seemingly paradoxically, were higher when mice made correct rather than incorrect choices. Single-trial behavioral choices depended not only on the stimulus information encoded by the whole population, but unexpectedly also on the consistency of information across neurons and time. Because correlations increased information consistency, they enhanced the conversion of sensory information into behavioral choices, overcoming their detrimental information-limiting effects. Thus, correlations in association cortex can benefit task performance even if they decrease sensory information.

KW - Animals

KW - Choice Behavior/physiology

KW - Mice

KW - Models, Neurological

KW - Neurons/physiology

KW - Parietal Lobe/physiology

U2 - 10.1038/s41593-021-00845-1

DO - 10.1038/s41593-021-00845-1

M3 - SCORING: Journal article

C2 - 33986549

VL - 24

SP - 975

EP - 986

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 7

ER -