Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy
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Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy. / Wenzel, Mike; Preisser, Felix; Wittler, Clarissa; Hoeh, Benedikt; Wild, Peter J; Tschäbunin, Alexandra; Bodelle, Boris; Würnschimmel, Christoph; Tilki, Derya; Graefen, Markus; Becker, Andreas; Karakiewicz, Pierre I; Chun, Felix K H; Kluth, Luis A; Köllermann, Jens; Mandel, Philipp.
In: DIAGNOSTICS, Vol. 11, No. 5, 882, 15.05.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy
AU - Wenzel, Mike
AU - Preisser, Felix
AU - Wittler, Clarissa
AU - Hoeh, Benedikt
AU - Wild, Peter J
AU - Tschäbunin, Alexandra
AU - Bodelle, Boris
AU - Würnschimmel, Christoph
AU - Tilki, Derya
AU - Graefen, Markus
AU - Becker, Andreas
AU - Karakiewicz, Pierre I
AU - Chun, Felix K H
AU - Kluth, Luis A
AU - Köllermann, Jens
AU - Mandel, Philipp
PY - 2021/5/15
Y1 - 2021/5/15
N2 - BACKGROUND: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear.METHODS: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients' TB and SB GS, as well as for the combined effect of SB + TB.RESULTS: Of 159 eligible patients, 77% were biopsy naïve. For SB taken in addition to TB, a Spearman's correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both p < 0.001), but a higher downgrading rate, relative to TB (p < 0.01).CONCLUSIONS: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate.
AB - BACKGROUND: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear.METHODS: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients' TB and SB GS, as well as for the combined effect of SB + TB.RESULTS: Of 159 eligible patients, 77% were biopsy naïve. For SB taken in addition to TB, a Spearman's correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both p < 0.001), but a higher downgrading rate, relative to TB (p < 0.01).CONCLUSIONS: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate.
U2 - 10.3390/diagnostics11050882
DO - 10.3390/diagnostics11050882
M3 - SCORING: Journal article
C2 - 34063557
VL - 11
JO - DIAGNOSTICS
JF - DIAGNOSTICS
SN - 2075-4418
IS - 5
M1 - 882
ER -