PortalPublikationenCorrelation of MRI-Lesion Targeted Biopsy vs. Systematic Bio...

Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy

Standard

Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy. / Wenzel, Mike; Preisser, Felix; Wittler, Clarissa; Hoeh, Benedikt; Wild, Peter J; Tschäbunin, Alexandra; Bodelle, Boris; Würnschimmel, Christoph; Tilki, Derya; Graefen, Markus; Becker, Andreas; Karakiewicz, Pierre I; Chun, Felix K H; Kluth, Luis A; Köllermann, Jens; Mandel, Philipp.

in: DIAGNOSTICS, Jahrgang 11, Nr. 5, 882, 15.05.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wenzel, M, Preisser, F, Wittler, C, Hoeh, B, Wild, PJ, Tschäbunin, A, Bodelle, B, Würnschimmel, C, Tilki, D, Graefen, M, Becker, A, Karakiewicz, PI, Chun, FKH, Kluth, LA, Köllermann, J & Mandel, P 2021, 'Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy', DIAGNOSTICS, Jg. 11, Nr. 5, 882. https://doi.org/10.3390/diagnostics11050882

APA

Wenzel, M., Preisser, F., Wittler, C., Hoeh, B., Wild, P. J., Tschäbunin, A., Bodelle, B., Würnschimmel, C., Tilki, D., Graefen, M., Becker, A., Karakiewicz, P. I., Chun, F. K. H., Kluth, L. A., Köllermann, J., & Mandel, P. (2021). Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy. DIAGNOSTICS, 11(5), [882]. https://doi.org/10.3390/diagnostics11050882

Vancouver

Wenzel M, Preisser F, Wittler C, Hoeh B, Wild PJ, Tschäbunin A et al. Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy. DIAGNOSTICS. 2021 Mai 15;11(5). 882. https://doi.org/10.3390/diagnostics11050882

Bibtex

@article{3f4ffdb008cd4ef9a92b51f4272ac2b7,
title = "Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy",
abstract = "BACKGROUND: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear.METHODS: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients' TB and SB GS, as well as for the combined effect of SB + TB.RESULTS: Of 159 eligible patients, 77% were biopsy na{\"i}ve. For SB taken in addition to TB, a Spearman's correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both p < 0.001), but a higher downgrading rate, relative to TB (p < 0.01).CONCLUSIONS: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate.",
author = "Mike Wenzel and Felix Preisser and Clarissa Wittler and Benedikt Hoeh and Wild, {Peter J} and Alexandra Tsch{\"a}bunin and Boris Bodelle and Christoph W{\"u}rnschimmel and Derya Tilki and Markus Graefen and Andreas Becker and Karakiewicz, {Pierre I} and Chun, {Felix K H} and Kluth, {Luis A} and Jens K{\"o}llermann and Philipp Mandel",
year = "2021",
month = may,
day = "15",
doi = "10.3390/diagnostics11050882",
language = "English",
volume = "11",
journal = "DIAGNOSTICS",
issn = "2075-4418",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Correlation of MRI-Lesion Targeted Biopsy vs. Systematic Biopsy Gleason Score with Final Pathological Gleason Score after Radical Prostatectomy

AU - Wenzel, Mike

AU - Preisser, Felix

AU - Wittler, Clarissa

AU - Hoeh, Benedikt

AU - Wild, Peter J

AU - Tschäbunin, Alexandra

AU - Bodelle, Boris

AU - Würnschimmel, Christoph

AU - Tilki, Derya

AU - Graefen, Markus

AU - Becker, Andreas

AU - Karakiewicz, Pierre I

AU - Chun, Felix K H

AU - Kluth, Luis A

AU - Köllermann, Jens

AU - Mandel, Philipp

PY - 2021/5/15

Y1 - 2021/5/15

N2 - BACKGROUND: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear.METHODS: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients' TB and SB GS, as well as for the combined effect of SB + TB.RESULTS: Of 159 eligible patients, 77% were biopsy naïve. For SB taken in addition to TB, a Spearman's correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both p < 0.001), but a higher downgrading rate, relative to TB (p < 0.01).CONCLUSIONS: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate.

AB - BACKGROUND: The impact of MRI-lesion targeted (TB) and systematic biopsy (SB) Gleason score (GS) as a predictor for final pathological GS still remains unclear.METHODS: All patients with TB + SB, and subsequent radical prostatectomy (RP) between 01/2014-12/2020 were analyzed. Rank correlation coefficient predicted concordance with pathological GS for patients' TB and SB GS, as well as for the combined effect of SB + TB.RESULTS: Of 159 eligible patients, 77% were biopsy naïve. For SB taken in addition to TB, a Spearman's correlation of +0.33 was observed regarding final GS. Rates of concordance, upgrading, and downgrading were 37.1, 37.1 and 25.8%, respectively. For TB, a +0.52 correlation was computed regarding final GS. Rates of concordance, upgrading and downgrading for TB biopsy GS were 45.9, 33.3, and 20.8%, respectively. For the combination of SB + TB, a correlation of +0.59 was observed. Rates of concordance, upgrading and downgrading were 49.7, 15.1 and 35.2%, respectively. The combined effect of SB + TB resulted in a lower upgrading rate, relative to TB and SB (both p < 0.001), but a higher downgrading rate, relative to TB (p < 0.01).CONCLUSIONS: GS obtained from TB provided higher concordance and lower upgrading and downgrading rates, relative to SB GS with regard to final pathology. The combined effect of SB + TB led to the highest concordance rate and the lowest upgrading rate.

U2 - 10.3390/diagnostics11050882

DO - 10.3390/diagnostics11050882

M3 - SCORING: Journal article

C2 - 34063557

VL - 11

JO - DIAGNOSTICS

JF - DIAGNOSTICS

SN - 2075-4418

IS - 5

M1 - 882

ER -