Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression.

TY - JOUR

T1 - Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression.

AU - Schlegel, S

AU - von Bardeleben, U

AU - Wiedemann, Klaus

AU - Frommberger, U

AU - Holsboer, F

PY - 1989

Y1 - 1989

N2 - We determined brain density and ventricular measurements with computerized tomography (CT) in 33 depressed patients and compared the results with basal plasma cortisol and its suppressibility by dexamethasone. Mean plasma cortisol was positively related to elevated ventricular brain ratio (VBR). No association could be found between dexamethasone suppression test (DST) status and VBR or any other CT parameter. Elevated plasma cortisol levels and increased VBRs were positively correlated with total scores on the Brief Psychiatric Rating Scale, the Global Assessment Scale and the Bech-Rafaelsen Melancholia Scale, but they were not significantly correlated with total score on the Hamilton Anxiety Scale.

AB - We determined brain density and ventricular measurements with computerized tomography (CT) in 33 depressed patients and compared the results with basal plasma cortisol and its suppressibility by dexamethasone. Mean plasma cortisol was positively related to elevated ventricular brain ratio (VBR). No association could be found between dexamethasone suppression test (DST) status and VBR or any other CT parameter. Elevated plasma cortisol levels and increased VBRs were positively correlated with total scores on the Brief Psychiatric Rating Scale, the Global Assessment Scale and the Bech-Rafaelsen Melancholia Scale, but they were not significantly correlated with total score on the Hamilton Anxiety Scale.

M3 - SCORING: Zeitschriftenaufsatz

VL - 14

SP - 209

EP - 216

JO - PSYCHONEUROENDOCRINO

JF - PSYCHONEUROENDOCRINO

SN - 0306-4530

IS - 3

M1 - 3

ER -