Computational analysis of functional connectivity between areas of primate cerebral cortex

TY - JOUR

T1 - Computational analysis of functional connectivity between areas of primate cerebral cortex

AU - Stephan, K E

AU - Hilgetag, C C

AU - Burns, G A

AU - O'Neill, M A

AU - Young, M P

AU - Kötter, R

PY - 2000/1/29

Y1 - 2000/1/29

N2 - Recent analyses of association fibre networks in the primate cerebral cortex have revealed a small number of densely intra-connected and hierarchically organized structural systems. Corresponding analyses of data on functional connectivity are required to establish the significance of these structural systems. We therefore built up a relational database by systematically collating published data on the spread of activity after strychnine-induced disinhibition in the macaque cerebral cortex in vivo. After mapping these data to two different parcellation schemes, we used three independent methods of analysis which demonstrate that the cortical network of functional interactions is not homogeneous, but shows a clear segregation into functional assemblies of mutually interacting areas. The assemblies suggest a principal division of the cortex into visual, somatomotor and orbito-temporo-insular systems, while motor and somatosensory areas are inseparably interrelated. These results are largely compatible with corresponding analyses of structural data of mammalian cerebral cortex, and deliver the first functional evidence for 'small-world' architecture of primate cerebral cortex.

AB - Recent analyses of association fibre networks in the primate cerebral cortex have revealed a small number of densely intra-connected and hierarchically organized structural systems. Corresponding analyses of data on functional connectivity are required to establish the significance of these structural systems. We therefore built up a relational database by systematically collating published data on the spread of activity after strychnine-induced disinhibition in the macaque cerebral cortex in vivo. After mapping these data to two different parcellation schemes, we used three independent methods of analysis which demonstrate that the cortical network of functional interactions is not homogeneous, but shows a clear segregation into functional assemblies of mutually interacting areas. The assemblies suggest a principal division of the cortex into visual, somatomotor and orbito-temporo-insular systems, while motor and somatosensory areas are inseparably interrelated. These results are largely compatible with corresponding analyses of structural data of mammalian cerebral cortex, and deliver the first functional evidence for 'small-world' architecture of primate cerebral cortex.

KW - Animals

KW - Brain Mapping

KW - Cerebral Cortex

KW - Cluster Analysis

KW - Convulsants

KW - Epilepsy

KW - Models, Neurological

KW - Neural Pathways

KW - Primates

KW - Strychnine

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1098/rstb.2000.0552

DO - 10.1098/rstb.2000.0552

M3 - SCORING: Journal article

C2 - 10703047

VL - 355

SP - 111

EP - 126

JO - PHILOS T R SOC B

JF - PHILOS T R SOC B

SN - 0962-8436

IS - 1393

ER -