Computational analysis of functional connectivity between areas of primate cerebral cortex
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Computational analysis of functional connectivity between areas of primate cerebral cortex. / Stephan, K E; Hilgetag, C C; Burns, G A; O'Neill, M A; Young, M P; Kötter, R.
in: PHILOS T R SOC B, Jahrgang 355, Nr. 1393, 29.01.2000, S. 111-26.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Computational analysis of functional connectivity between areas of primate cerebral cortex
AU - Stephan, K E
AU - Hilgetag, C C
AU - Burns, G A
AU - O'Neill, M A
AU - Young, M P
AU - Kötter, R
PY - 2000/1/29
Y1 - 2000/1/29
N2 - Recent analyses of association fibre networks in the primate cerebral cortex have revealed a small number of densely intra-connected and hierarchically organized structural systems. Corresponding analyses of data on functional connectivity are required to establish the significance of these structural systems. We therefore built up a relational database by systematically collating published data on the spread of activity after strychnine-induced disinhibition in the macaque cerebral cortex in vivo. After mapping these data to two different parcellation schemes, we used three independent methods of analysis which demonstrate that the cortical network of functional interactions is not homogeneous, but shows a clear segregation into functional assemblies of mutually interacting areas. The assemblies suggest a principal division of the cortex into visual, somatomotor and orbito-temporo-insular systems, while motor and somatosensory areas are inseparably interrelated. These results are largely compatible with corresponding analyses of structural data of mammalian cerebral cortex, and deliver the first functional evidence for 'small-world' architecture of primate cerebral cortex.
AB - Recent analyses of association fibre networks in the primate cerebral cortex have revealed a small number of densely intra-connected and hierarchically organized structural systems. Corresponding analyses of data on functional connectivity are required to establish the significance of these structural systems. We therefore built up a relational database by systematically collating published data on the spread of activity after strychnine-induced disinhibition in the macaque cerebral cortex in vivo. After mapping these data to two different parcellation schemes, we used three independent methods of analysis which demonstrate that the cortical network of functional interactions is not homogeneous, but shows a clear segregation into functional assemblies of mutually interacting areas. The assemblies suggest a principal division of the cortex into visual, somatomotor and orbito-temporo-insular systems, while motor and somatosensory areas are inseparably interrelated. These results are largely compatible with corresponding analyses of structural data of mammalian cerebral cortex, and deliver the first functional evidence for 'small-world' architecture of primate cerebral cortex.
KW - Animals
KW - Brain Mapping
KW - Cerebral Cortex
KW - Cluster Analysis
KW - Convulsants
KW - Epilepsy
KW - Models, Neurological
KW - Neural Pathways
KW - Primates
KW - Strychnine
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1098/rstb.2000.0552
DO - 10.1098/rstb.2000.0552
M3 - SCORING: Journal article
C2 - 10703047
VL - 355
SP - 111
EP - 126
JO - PHILOS T R SOC B
JF - PHILOS T R SOC B
SN - 0962-8436
IS - 1393
ER -