Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection
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Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection. / Morgner, A; Miehlke, S; Fischbach, W; Schmitt, W; Müller-Hermelink, H; Greiner, A; Thiede, C; Schetelig, J; Neubauer, A; Stolte, M; Ehninger, G; Bayerdörffer, E.
In: J CLIN ONCOL, Vol. 19, No. 7, 01.04.2001, p. 2041-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection
AU - Morgner, A
AU - Miehlke, S
AU - Fischbach, W
AU - Schmitt, W
AU - Müller-Hermelink, H
AU - Greiner, A
AU - Thiede, C
AU - Schetelig, J
AU - Neubauer, A
AU - Stolte, M
AU - Ehninger, G
AU - Bayerdörffer, E
PY - 2001/4/1
Y1 - 2001/4/1
N2 - PURPOSE: Treatment of low-grade gastric mucosa-associated lymphoid tissue lymphoma by eradication of Helicobacter pylori is reported to result in complete lymphoma remission in approximately 75% of cases. The effect that cure of the infection has on the course of a primary high-grade gastric lymphoma is largely uncertain. The aim of this study was to report the effect of cure of H pylori infection exerted in patients with high-grade B-cell gastric lymphoma.PATIENTS AND METHODS: Eight patients (4 males and 4 females; age range, 26 to 85 years) with H pylori infection and high-grade lymphoma received eradication therapy before planned treatment. The effect of H pylori eradication on the course of high-grade lymphoma was assessed by analysis of surgical specimens (n = 2) or endoscopic biopsies (n = 6).RESULTS: H pylori eradication was successful in all patients and led to complete remission of the lymphoma in seven patients. One patient has experienced partial remission. Two patients were referred to surgery, one of whom (stage II(1E)) had lymph node involvement, and the histologic work-up of the resected stomach revealed residual infiltrates of a low-grade lymphoma, which prompted consolidation chemotherapy. In one patient (initially stage I(1E)), abdominal lymphoma developed 6 months after eradication therapy, which regressed completely after chemotherapy. In four patients, no further treatment was given. Six patients continue in complete remission (range, 6 to 66 months).CONCLUSION: Primary high-grade B-cell gastric lymphoma in stages I(E) through II(E1) associated with H pylori may regress completely after successful cure of the infection. Prospective trials are needed to investigate this treatment in larger numbers of patients.
AB - PURPOSE: Treatment of low-grade gastric mucosa-associated lymphoid tissue lymphoma by eradication of Helicobacter pylori is reported to result in complete lymphoma remission in approximately 75% of cases. The effect that cure of the infection has on the course of a primary high-grade gastric lymphoma is largely uncertain. The aim of this study was to report the effect of cure of H pylori infection exerted in patients with high-grade B-cell gastric lymphoma.PATIENTS AND METHODS: Eight patients (4 males and 4 females; age range, 26 to 85 years) with H pylori infection and high-grade lymphoma received eradication therapy before planned treatment. The effect of H pylori eradication on the course of high-grade lymphoma was assessed by analysis of surgical specimens (n = 2) or endoscopic biopsies (n = 6).RESULTS: H pylori eradication was successful in all patients and led to complete remission of the lymphoma in seven patients. One patient has experienced partial remission. Two patients were referred to surgery, one of whom (stage II(1E)) had lymph node involvement, and the histologic work-up of the resected stomach revealed residual infiltrates of a low-grade lymphoma, which prompted consolidation chemotherapy. In one patient (initially stage I(1E)), abdominal lymphoma developed 6 months after eradication therapy, which regressed completely after chemotherapy. In four patients, no further treatment was given. Six patients continue in complete remission (range, 6 to 66 months).CONCLUSION: Primary high-grade B-cell gastric lymphoma in stages I(E) through II(E1) associated with H pylori may regress completely after successful cure of the infection. Prospective trials are needed to investigate this treatment in larger numbers of patients.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Amoxicillin
KW - Anti-Ulcer Agents
KW - Cell Transformation, Neoplastic
KW - Female
KW - Helicobacter Infections
KW - Helicobacter pylori
KW - Humans
KW - Lymphoma, B-Cell
KW - Lymphoma, B-Cell, Marginal Zone
KW - Lymphoma, Non-Hodgkin
KW - Male
KW - Middle Aged
KW - Omeprazole
KW - Penicillins
KW - Remission Induction
KW - Retrospective Studies
KW - Stomach Neoplasms
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1200/jco.2001.19.7.2041
DO - 10.1200/jco.2001.19.7.2041
M3 - SCORING: Journal article
C2 - 11283137
VL - 19
SP - 2041
EP - 2048
JO - J CLIN ONCOL
JF - J CLIN ONCOL
SN - 0732-183X
IS - 7
ER -