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Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection

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Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection. / Morgner, A; Miehlke, S; Fischbach, W; Schmitt, W; Müller-Hermelink, H; Greiner, A; Thiede, C; Schetelig, J; Neubauer, A; Stolte, M; Ehninger, G; Bayerdörffer, E.

in: J CLIN ONCOL, Jahrgang 19, Nr. 7, 01.04.2001, S. 2041-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Morgner, A, Miehlke, S, Fischbach, W, Schmitt, W, Müller-Hermelink, H, Greiner, A, Thiede, C, Schetelig, J, Neubauer, A, Stolte, M, Ehninger, G & Bayerdörffer, E 2001, 'Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection', J CLIN ONCOL, Jg. 19, Nr. 7, S. 2041-8. https://doi.org/10.1200/jco.2001.19.7.2041

APA

Morgner, A., Miehlke, S., Fischbach, W., Schmitt, W., Müller-Hermelink, H., Greiner, A., Thiede, C., Schetelig, J., Neubauer, A., Stolte, M., Ehninger, G., & Bayerdörffer, E. (2001). Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection. J CLIN ONCOL, 19(7), 2041-8. https://doi.org/10.1200/jco.2001.19.7.2041

Vancouver

Morgner A, Miehlke S, Fischbach W, Schmitt W, Müller-Hermelink H, Greiner A et al. Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection. J CLIN ONCOL. 2001 Apr 1;19(7):2041-8. https://doi.org/10.1200/jco.2001.19.7.2041

Bibtex

@article{14748a8876f444d5b01a017ef1b0a18b,
title = "Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection",
abstract = "PURPOSE: Treatment of low-grade gastric mucosa-associated lymphoid tissue lymphoma by eradication of Helicobacter pylori is reported to result in complete lymphoma remission in approximately 75% of cases. The effect that cure of the infection has on the course of a primary high-grade gastric lymphoma is largely uncertain. The aim of this study was to report the effect of cure of H pylori infection exerted in patients with high-grade B-cell gastric lymphoma.PATIENTS AND METHODS: Eight patients (4 males and 4 females; age range, 26 to 85 years) with H pylori infection and high-grade lymphoma received eradication therapy before planned treatment. The effect of H pylori eradication on the course of high-grade lymphoma was assessed by analysis of surgical specimens (n = 2) or endoscopic biopsies (n = 6).RESULTS: H pylori eradication was successful in all patients and led to complete remission of the lymphoma in seven patients. One patient has experienced partial remission. Two patients were referred to surgery, one of whom (stage II(1E)) had lymph node involvement, and the histologic work-up of the resected stomach revealed residual infiltrates of a low-grade lymphoma, which prompted consolidation chemotherapy. In one patient (initially stage I(1E)), abdominal lymphoma developed 6 months after eradication therapy, which regressed completely after chemotherapy. In four patients, no further treatment was given. Six patients continue in complete remission (range, 6 to 66 months).CONCLUSION: Primary high-grade B-cell gastric lymphoma in stages I(E) through II(E1) associated with H pylori may regress completely after successful cure of the infection. Prospective trials are needed to investigate this treatment in larger numbers of patients.",
keywords = "Adult, Aged, Aged, 80 and over, Amoxicillin, Anti-Ulcer Agents, Cell Transformation, Neoplastic, Female, Helicobacter Infections, Helicobacter pylori, Humans, Lymphoma, B-Cell, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Non-Hodgkin, Male, Middle Aged, Omeprazole, Penicillins, Remission Induction, Retrospective Studies, Stomach Neoplasms, Journal Article, Research Support, Non-U.S. Gov't",
author = "A Morgner and S Miehlke and W Fischbach and W Schmitt and H M{\"u}ller-Hermelink and A Greiner and C Thiede and J Schetelig and A Neubauer and M Stolte and G Ehninger and E Bayerd{\"o}rffer",
year = "2001",
month = apr,
day = "1",
doi = "10.1200/jco.2001.19.7.2041",
language = "English",
volume = "19",
pages = "2041--8",
journal = "J CLIN ONCOL",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "7",

}

RIS

TY - JOUR

T1 - Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection

AU - Morgner, A

AU - Miehlke, S

AU - Fischbach, W

AU - Schmitt, W

AU - Müller-Hermelink, H

AU - Greiner, A

AU - Thiede, C

AU - Schetelig, J

AU - Neubauer, A

AU - Stolte, M

AU - Ehninger, G

AU - Bayerdörffer, E

PY - 2001/4/1

Y1 - 2001/4/1

N2 - PURPOSE: Treatment of low-grade gastric mucosa-associated lymphoid tissue lymphoma by eradication of Helicobacter pylori is reported to result in complete lymphoma remission in approximately 75% of cases. The effect that cure of the infection has on the course of a primary high-grade gastric lymphoma is largely uncertain. The aim of this study was to report the effect of cure of H pylori infection exerted in patients with high-grade B-cell gastric lymphoma.PATIENTS AND METHODS: Eight patients (4 males and 4 females; age range, 26 to 85 years) with H pylori infection and high-grade lymphoma received eradication therapy before planned treatment. The effect of H pylori eradication on the course of high-grade lymphoma was assessed by analysis of surgical specimens (n = 2) or endoscopic biopsies (n = 6).RESULTS: H pylori eradication was successful in all patients and led to complete remission of the lymphoma in seven patients. One patient has experienced partial remission. Two patients were referred to surgery, one of whom (stage II(1E)) had lymph node involvement, and the histologic work-up of the resected stomach revealed residual infiltrates of a low-grade lymphoma, which prompted consolidation chemotherapy. In one patient (initially stage I(1E)), abdominal lymphoma developed 6 months after eradication therapy, which regressed completely after chemotherapy. In four patients, no further treatment was given. Six patients continue in complete remission (range, 6 to 66 months).CONCLUSION: Primary high-grade B-cell gastric lymphoma in stages I(E) through II(E1) associated with H pylori may regress completely after successful cure of the infection. Prospective trials are needed to investigate this treatment in larger numbers of patients.

AB - PURPOSE: Treatment of low-grade gastric mucosa-associated lymphoid tissue lymphoma by eradication of Helicobacter pylori is reported to result in complete lymphoma remission in approximately 75% of cases. The effect that cure of the infection has on the course of a primary high-grade gastric lymphoma is largely uncertain. The aim of this study was to report the effect of cure of H pylori infection exerted in patients with high-grade B-cell gastric lymphoma.PATIENTS AND METHODS: Eight patients (4 males and 4 females; age range, 26 to 85 years) with H pylori infection and high-grade lymphoma received eradication therapy before planned treatment. The effect of H pylori eradication on the course of high-grade lymphoma was assessed by analysis of surgical specimens (n = 2) or endoscopic biopsies (n = 6).RESULTS: H pylori eradication was successful in all patients and led to complete remission of the lymphoma in seven patients. One patient has experienced partial remission. Two patients were referred to surgery, one of whom (stage II(1E)) had lymph node involvement, and the histologic work-up of the resected stomach revealed residual infiltrates of a low-grade lymphoma, which prompted consolidation chemotherapy. In one patient (initially stage I(1E)), abdominal lymphoma developed 6 months after eradication therapy, which regressed completely after chemotherapy. In four patients, no further treatment was given. Six patients continue in complete remission (range, 6 to 66 months).CONCLUSION: Primary high-grade B-cell gastric lymphoma in stages I(E) through II(E1) associated with H pylori may regress completely after successful cure of the infection. Prospective trials are needed to investigate this treatment in larger numbers of patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Amoxicillin

KW - Anti-Ulcer Agents

KW - Cell Transformation, Neoplastic

KW - Female

KW - Helicobacter Infections

KW - Helicobacter pylori

KW - Humans

KW - Lymphoma, B-Cell

KW - Lymphoma, B-Cell, Marginal Zone

KW - Lymphoma, Non-Hodgkin

KW - Male

KW - Middle Aged

KW - Omeprazole

KW - Penicillins

KW - Remission Induction

KW - Retrospective Studies

KW - Stomach Neoplasms

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1200/jco.2001.19.7.2041

DO - 10.1200/jco.2001.19.7.2041

M3 - SCORING: Journal article

C2 - 11283137

VL - 19

SP - 2041

EP - 2048

JO - J CLIN ONCOL

JF - J CLIN ONCOL

SN - 0732-183X

IS - 7

ER -