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Complementary encoding of spatial information in hippocampal astrocytes

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Complementary encoding of spatial information in hippocampal astrocytes. / Curreli, Sebastiano; Bonato, Jacopo; Romanzi, Sara; Panzeri, Stefano; Fellin, Tommaso.

In: PLOS BIOL, Vol. 20, No. 3, e3001530, 03.03.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Curreli, S, Bonato, J, Romanzi, S, Panzeri, S & Fellin, T 2022, 'Complementary encoding of spatial information in hippocampal astrocytes', PLOS BIOL, vol. 20, no. 3, e3001530. https://doi.org/10.1371/journal.pbio.3001530

APA

Curreli, S., Bonato, J., Romanzi, S., Panzeri, S., & Fellin, T. (2022). Complementary encoding of spatial information in hippocampal astrocytes. PLOS BIOL, 20(3), [e3001530]. https://doi.org/10.1371/journal.pbio.3001530

Vancouver

Curreli S, Bonato J, Romanzi S, Panzeri S, Fellin T. Complementary encoding of spatial information in hippocampal astrocytes. PLOS BIOL. 2022 Mar 3;20(3). e3001530. https://doi.org/10.1371/journal.pbio.3001530

Bibtex

@article{f75ad18829374daaa9033b536679d622,
title = "Complementary encoding of spatial information in hippocampal astrocytes",
abstract = "Calcium dynamics into astrocytes influence the activity of nearby neuronal structures. However, because previous reports show that astrocytic calcium signals largely mirror neighboring neuronal activity, current information coding models neglect astrocytes. Using simultaneous two-photon calcium imaging of astrocytes and neurons in the hippocampus of mice navigating a virtual environment, we demonstrate that astrocytic calcium signals encode (i.e., statistically reflect) spatial information that could not be explained by visual cue information. Calcium events carrying spatial information occurred in topographically organized astrocytic subregions. Importantly, astrocytes encoded spatial information that was complementary and synergistic to that carried by neurons, improving spatial position decoding when astrocytic signals were considered alongside neuronal ones. These results suggest that the complementary place dependence of localized astrocytic calcium signals may regulate clusters of nearby synapses, enabling dynamic, context-dependent variations in population coding within brain circuits.",
author = "Sebastiano Curreli and Jacopo Bonato and Sara Romanzi and Stefano Panzeri and Tommaso Fellin",
year = "2022",
month = mar,
day = "3",
doi = "10.1371/journal.pbio.3001530",
language = "English",
volume = "20",
journal = "PLOS BIOL",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Complementary encoding of spatial information in hippocampal astrocytes

AU - Curreli, Sebastiano

AU - Bonato, Jacopo

AU - Romanzi, Sara

AU - Panzeri, Stefano

AU - Fellin, Tommaso

PY - 2022/3/3

Y1 - 2022/3/3

N2 - Calcium dynamics into astrocytes influence the activity of nearby neuronal structures. However, because previous reports show that astrocytic calcium signals largely mirror neighboring neuronal activity, current information coding models neglect astrocytes. Using simultaneous two-photon calcium imaging of astrocytes and neurons in the hippocampus of mice navigating a virtual environment, we demonstrate that astrocytic calcium signals encode (i.e., statistically reflect) spatial information that could not be explained by visual cue information. Calcium events carrying spatial information occurred in topographically organized astrocytic subregions. Importantly, astrocytes encoded spatial information that was complementary and synergistic to that carried by neurons, improving spatial position decoding when astrocytic signals were considered alongside neuronal ones. These results suggest that the complementary place dependence of localized astrocytic calcium signals may regulate clusters of nearby synapses, enabling dynamic, context-dependent variations in population coding within brain circuits.

AB - Calcium dynamics into astrocytes influence the activity of nearby neuronal structures. However, because previous reports show that astrocytic calcium signals largely mirror neighboring neuronal activity, current information coding models neglect astrocytes. Using simultaneous two-photon calcium imaging of astrocytes and neurons in the hippocampus of mice navigating a virtual environment, we demonstrate that astrocytic calcium signals encode (i.e., statistically reflect) spatial information that could not be explained by visual cue information. Calcium events carrying spatial information occurred in topographically organized astrocytic subregions. Importantly, astrocytes encoded spatial information that was complementary and synergistic to that carried by neurons, improving spatial position decoding when astrocytic signals were considered alongside neuronal ones. These results suggest that the complementary place dependence of localized astrocytic calcium signals may regulate clusters of nearby synapses, enabling dynamic, context-dependent variations in population coding within brain circuits.

U2 - 10.1371/journal.pbio.3001530

DO - 10.1371/journal.pbio.3001530

M3 - SCORING: Journal article

C2 - 35239646

VL - 20

JO - PLOS BIOL

JF - PLOS BIOL

SN - 1544-9173

IS - 3

M1 - e3001530

ER -