Complementary encoding of spatial information in hippocampal astrocytes
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Complementary encoding of spatial information in hippocampal astrocytes. / Curreli, Sebastiano; Bonato, Jacopo; Romanzi, Sara; Panzeri, Stefano; Fellin, Tommaso.
in: PLOS BIOL, Jahrgang 20, Nr. 3, e3001530, 03.03.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Complementary encoding of spatial information in hippocampal astrocytes
AU - Curreli, Sebastiano
AU - Bonato, Jacopo
AU - Romanzi, Sara
AU - Panzeri, Stefano
AU - Fellin, Tommaso
PY - 2022/3/3
Y1 - 2022/3/3
N2 - Calcium dynamics into astrocytes influence the activity of nearby neuronal structures. However, because previous reports show that astrocytic calcium signals largely mirror neighboring neuronal activity, current information coding models neglect astrocytes. Using simultaneous two-photon calcium imaging of astrocytes and neurons in the hippocampus of mice navigating a virtual environment, we demonstrate that astrocytic calcium signals encode (i.e., statistically reflect) spatial information that could not be explained by visual cue information. Calcium events carrying spatial information occurred in topographically organized astrocytic subregions. Importantly, astrocytes encoded spatial information that was complementary and synergistic to that carried by neurons, improving spatial position decoding when astrocytic signals were considered alongside neuronal ones. These results suggest that the complementary place dependence of localized astrocytic calcium signals may regulate clusters of nearby synapses, enabling dynamic, context-dependent variations in population coding within brain circuits.
AB - Calcium dynamics into astrocytes influence the activity of nearby neuronal structures. However, because previous reports show that astrocytic calcium signals largely mirror neighboring neuronal activity, current information coding models neglect astrocytes. Using simultaneous two-photon calcium imaging of astrocytes and neurons in the hippocampus of mice navigating a virtual environment, we demonstrate that astrocytic calcium signals encode (i.e., statistically reflect) spatial information that could not be explained by visual cue information. Calcium events carrying spatial information occurred in topographically organized astrocytic subregions. Importantly, astrocytes encoded spatial information that was complementary and synergistic to that carried by neurons, improving spatial position decoding when astrocytic signals were considered alongside neuronal ones. These results suggest that the complementary place dependence of localized astrocytic calcium signals may regulate clusters of nearby synapses, enabling dynamic, context-dependent variations in population coding within brain circuits.
U2 - 10.1371/journal.pbio.3001530
DO - 10.1371/journal.pbio.3001530
M3 - SCORING: Journal article
C2 - 35239646
VL - 20
JO - PLOS BIOL
JF - PLOS BIOL
SN - 1544-9173
IS - 3
M1 - e3001530
ER -