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Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains

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Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains. / Wenger, Elisabeth; Mårtensson, Johan; Noack, Hannes; Bodammer, Nils Christian; Kühn, Simone; Schaefer, Sabine; Heinze, Hans-Jochen; Düzel, Emrah; Bäckman, Lars; Lindenberger, Ulman; Lövdén, Martin.

In: HUM BRAIN MAPP, Vol. 35, No. 8, 08.2014, p. 4236-48.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wenger, E, Mårtensson, J, Noack, H, Bodammer, NC, Kühn, S, Schaefer, S, Heinze, H-J, Düzel, E, Bäckman, L, Lindenberger, U & Lövdén, M 2014, 'Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains', HUM BRAIN MAPP, vol. 35, no. 8, pp. 4236-48. https://doi.org/10.1002/hbm.22473

APA

Wenger, E., Mårtensson, J., Noack, H., Bodammer, N. C., Kühn, S., Schaefer, S., Heinze, H-J., Düzel, E., Bäckman, L., Lindenberger, U., & Lövdén, M. (2014). Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains. HUM BRAIN MAPP, 35(8), 4236-48. https://doi.org/10.1002/hbm.22473

Vancouver

Wenger E, Mårtensson J, Noack H, Bodammer NC, Kühn S, Schaefer S et al. Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains. HUM BRAIN MAPP. 2014 Aug;35(8):4236-48. https://doi.org/10.1002/hbm.22473

Bibtex

@article{67a4da40dae94320833208dc51e02c2e,
title = "Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains",
abstract = "We compared hippocampal volume measures obtained by manual tracing to automatic segmentation with FreeSurfer in 44 younger (20-30 years) and 47 older (60-70 years) adults, each measured with magnetic resonance imaging (MRI) over three successive time points, separated by four months. Retest correlations over time were very high for both manual and FreeSurfer segmentations. With FreeSurfer, correlations over time were significantly lower in the older than in the younger age group, which was not the case with manual segmentation. Pearson correlations between manual and FreeSurfer estimates were sufficiently high, numerically even higher in the younger group, whereas intra-class correlation coefficient (ICC) estimates were lower in the younger than in the older group. FreeSurfer yielded higher volume estimates than manual segmentation, particularly in the younger age group. Importantly, FreeSurfer consistently overestimated hippocampal volumes independently of manually assessed volume in the younger age group, but overestimated larger volumes in the older age group to a less extent, introducing a systematic age bias in the data. Age differences in hippocampal volumes were significant with FreeSurfer, but not with manual tracing. Manual tracing resulted in a significant difference between left and right hippocampus (right > left), whereas this asymmetry effect was considerably smaller with FreeSurfer estimates. We conclude that FreeSurfer constitutes a feasible method to assess differences in hippocampal volume in young adults. FreeSurfer estimates in older age groups should, however, be interpreted with care until the automatic segmentation pipeline has been further optimized to increase validity and reliability in this age group.",
keywords = "Adult, Aged, Feasibility Studies, Functional Laterality, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Middle Aged, Organ Size, Pattern Recognition, Automated, Reproducibility of Results, Signal Processing, Computer-Assisted, Software, Young Adult",
author = "Elisabeth Wenger and Johan M{\aa}rtensson and Hannes Noack and Bodammer, {Nils Christian} and Simone K{\"u}hn and Sabine Schaefer and Hans-Jochen Heinze and Emrah D{\"u}zel and Lars B{\"a}ckman and Ulman Lindenberger and Martin L{\"o}vd{\'e}n",
note = "Copyright {\textcopyright} 2014 Wiley Periodicals, Inc.",
year = "2014",
month = aug,
doi = "10.1002/hbm.22473",
language = "English",
volume = "35",
pages = "4236--48",
journal = "HUM BRAIN MAPP",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains

AU - Wenger, Elisabeth

AU - Mårtensson, Johan

AU - Noack, Hannes

AU - Bodammer, Nils Christian

AU - Kühn, Simone

AU - Schaefer, Sabine

AU - Heinze, Hans-Jochen

AU - Düzel, Emrah

AU - Bäckman, Lars

AU - Lindenberger, Ulman

AU - Lövdén, Martin

N1 - Copyright © 2014 Wiley Periodicals, Inc.

PY - 2014/8

Y1 - 2014/8

N2 - We compared hippocampal volume measures obtained by manual tracing to automatic segmentation with FreeSurfer in 44 younger (20-30 years) and 47 older (60-70 years) adults, each measured with magnetic resonance imaging (MRI) over three successive time points, separated by four months. Retest correlations over time were very high for both manual and FreeSurfer segmentations. With FreeSurfer, correlations over time were significantly lower in the older than in the younger age group, which was not the case with manual segmentation. Pearson correlations between manual and FreeSurfer estimates were sufficiently high, numerically even higher in the younger group, whereas intra-class correlation coefficient (ICC) estimates were lower in the younger than in the older group. FreeSurfer yielded higher volume estimates than manual segmentation, particularly in the younger age group. Importantly, FreeSurfer consistently overestimated hippocampal volumes independently of manually assessed volume in the younger age group, but overestimated larger volumes in the older age group to a less extent, introducing a systematic age bias in the data. Age differences in hippocampal volumes were significant with FreeSurfer, but not with manual tracing. Manual tracing resulted in a significant difference between left and right hippocampus (right > left), whereas this asymmetry effect was considerably smaller with FreeSurfer estimates. We conclude that FreeSurfer constitutes a feasible method to assess differences in hippocampal volume in young adults. FreeSurfer estimates in older age groups should, however, be interpreted with care until the automatic segmentation pipeline has been further optimized to increase validity and reliability in this age group.

AB - We compared hippocampal volume measures obtained by manual tracing to automatic segmentation with FreeSurfer in 44 younger (20-30 years) and 47 older (60-70 years) adults, each measured with magnetic resonance imaging (MRI) over three successive time points, separated by four months. Retest correlations over time were very high for both manual and FreeSurfer segmentations. With FreeSurfer, correlations over time were significantly lower in the older than in the younger age group, which was not the case with manual segmentation. Pearson correlations between manual and FreeSurfer estimates were sufficiently high, numerically even higher in the younger group, whereas intra-class correlation coefficient (ICC) estimates were lower in the younger than in the older group. FreeSurfer yielded higher volume estimates than manual segmentation, particularly in the younger age group. Importantly, FreeSurfer consistently overestimated hippocampal volumes independently of manually assessed volume in the younger age group, but overestimated larger volumes in the older age group to a less extent, introducing a systematic age bias in the data. Age differences in hippocampal volumes were significant with FreeSurfer, but not with manual tracing. Manual tracing resulted in a significant difference between left and right hippocampus (right > left), whereas this asymmetry effect was considerably smaller with FreeSurfer estimates. We conclude that FreeSurfer constitutes a feasible method to assess differences in hippocampal volume in young adults. FreeSurfer estimates in older age groups should, however, be interpreted with care until the automatic segmentation pipeline has been further optimized to increase validity and reliability in this age group.

KW - Adult

KW - Aged

KW - Feasibility Studies

KW - Functional Laterality

KW - Hippocampus

KW - Humans

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Middle Aged

KW - Organ Size

KW - Pattern Recognition, Automated

KW - Reproducibility of Results

KW - Signal Processing, Computer-Assisted

KW - Software

KW - Young Adult

U2 - 10.1002/hbm.22473

DO - 10.1002/hbm.22473

M3 - SCORING: Journal article

C2 - 24532539

VL - 35

SP - 4236

EP - 4248

JO - HUM BRAIN MAPP

JF - HUM BRAIN MAPP

SN - 1065-9471

IS - 8

ER -