Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains
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Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains. / Wenger, Elisabeth; Mårtensson, Johan; Noack, Hannes; Bodammer, Nils Christian; Kühn, Simone; Schaefer, Sabine; Heinze, Hans-Jochen; Düzel, Emrah; Bäckman, Lars; Lindenberger, Ulman; Lövdén, Martin.
in: HUM BRAIN MAPP, Jahrgang 35, Nr. 8, 08.2014, S. 4236-48.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Comparing manual and automatic segmentation of hippocampal volumes: reliability and validity issues in younger and older brains
AU - Wenger, Elisabeth
AU - Mårtensson, Johan
AU - Noack, Hannes
AU - Bodammer, Nils Christian
AU - Kühn, Simone
AU - Schaefer, Sabine
AU - Heinze, Hans-Jochen
AU - Düzel, Emrah
AU - Bäckman, Lars
AU - Lindenberger, Ulman
AU - Lövdén, Martin
N1 - Copyright © 2014 Wiley Periodicals, Inc.
PY - 2014/8
Y1 - 2014/8
N2 - We compared hippocampal volume measures obtained by manual tracing to automatic segmentation with FreeSurfer in 44 younger (20-30 years) and 47 older (60-70 years) adults, each measured with magnetic resonance imaging (MRI) over three successive time points, separated by four months. Retest correlations over time were very high for both manual and FreeSurfer segmentations. With FreeSurfer, correlations over time were significantly lower in the older than in the younger age group, which was not the case with manual segmentation. Pearson correlations between manual and FreeSurfer estimates were sufficiently high, numerically even higher in the younger group, whereas intra-class correlation coefficient (ICC) estimates were lower in the younger than in the older group. FreeSurfer yielded higher volume estimates than manual segmentation, particularly in the younger age group. Importantly, FreeSurfer consistently overestimated hippocampal volumes independently of manually assessed volume in the younger age group, but overestimated larger volumes in the older age group to a less extent, introducing a systematic age bias in the data. Age differences in hippocampal volumes were significant with FreeSurfer, but not with manual tracing. Manual tracing resulted in a significant difference between left and right hippocampus (right > left), whereas this asymmetry effect was considerably smaller with FreeSurfer estimates. We conclude that FreeSurfer constitutes a feasible method to assess differences in hippocampal volume in young adults. FreeSurfer estimates in older age groups should, however, be interpreted with care until the automatic segmentation pipeline has been further optimized to increase validity and reliability in this age group.
AB - We compared hippocampal volume measures obtained by manual tracing to automatic segmentation with FreeSurfer in 44 younger (20-30 years) and 47 older (60-70 years) adults, each measured with magnetic resonance imaging (MRI) over three successive time points, separated by four months. Retest correlations over time were very high for both manual and FreeSurfer segmentations. With FreeSurfer, correlations over time were significantly lower in the older than in the younger age group, which was not the case with manual segmentation. Pearson correlations between manual and FreeSurfer estimates were sufficiently high, numerically even higher in the younger group, whereas intra-class correlation coefficient (ICC) estimates were lower in the younger than in the older group. FreeSurfer yielded higher volume estimates than manual segmentation, particularly in the younger age group. Importantly, FreeSurfer consistently overestimated hippocampal volumes independently of manually assessed volume in the younger age group, but overestimated larger volumes in the older age group to a less extent, introducing a systematic age bias in the data. Age differences in hippocampal volumes were significant with FreeSurfer, but not with manual tracing. Manual tracing resulted in a significant difference between left and right hippocampus (right > left), whereas this asymmetry effect was considerably smaller with FreeSurfer estimates. We conclude that FreeSurfer constitutes a feasible method to assess differences in hippocampal volume in young adults. FreeSurfer estimates in older age groups should, however, be interpreted with care until the automatic segmentation pipeline has been further optimized to increase validity and reliability in this age group.
KW - Adult
KW - Aged
KW - Feasibility Studies
KW - Functional Laterality
KW - Hippocampus
KW - Humans
KW - Longitudinal Studies
KW - Magnetic Resonance Imaging
KW - Middle Aged
KW - Organ Size
KW - Pattern Recognition, Automated
KW - Reproducibility of Results
KW - Signal Processing, Computer-Assisted
KW - Software
KW - Young Adult
U2 - 10.1002/hbm.22473
DO - 10.1002/hbm.22473
M3 - SCORING: Journal article
C2 - 24532539
VL - 35
SP - 4236
EP - 4248
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 8
ER -