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Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.

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Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. / Buerger, H; Otterbach, F; Simon, Ronald; Poremba, C; Diallo, R; Decker, T; Riethdorf, L; Brinkschmidt, C; Dockhorn-Dworniczak, B; Boecker, W.

In: J PATHOL, Vol. 187, No. 4, 4, 1999, p. 396-402.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Buerger, H, Otterbach, F, Simon, R, Poremba, C, Diallo, R, Decker, T, Riethdorf, L, Brinkschmidt, C, Dockhorn-Dworniczak, B & Boecker, W 1999, 'Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.', J PATHOL, vol. 187, no. 4, 4, pp. 396-402. <http://www.ncbi.nlm.nih.gov/pubmed/10398097?dopt=Citation>

APA

Buerger, H., Otterbach, F., Simon, R., Poremba, C., Diallo, R., Decker, T., Riethdorf, L., Brinkschmidt, C., Dockhorn-Dworniczak, B., & Boecker, W. (1999). Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. J PATHOL, 187(4), 396-402. [4]. http://www.ncbi.nlm.nih.gov/pubmed/10398097?dopt=Citation

Vancouver

Buerger H, Otterbach F, Simon R, Poremba C, Diallo R, Decker T et al. Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. J PATHOL. 1999;187(4):396-402. 4.

Bibtex

@article{dc913f5b4dbe45c19f3a270b0f9ddbe3,
title = "Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.",
abstract = "There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin-embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative genomic hybridization (CGH). Losses of 16q material were seen almost exclusively in well- and intermediately-differentiated DCIS. These two subgroups differed in the average number of genetic imbalances, 2.5 and 5.5 respectively. Additionally, a higher frequency of gains of 1q and losses of 11q material was seen in intermediately-differentiated in contrast to well-differentiated DCIS. Poorly-differentiated DCIS displayed a higher frequency of amplifications (17q12, 11q13) and a higher average rate of genetic imbalances (7.1). Analysis of adjacent invasive breast carcinoma revealed a genetic pattern almost identical to the one seen in the DCIS counterpart. These data characterize DCIS as a genetically far-advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer.",
author = "H Buerger and F Otterbach and Ronald Simon and C Poremba and R Diallo and T Decker and L Riethdorf and C Brinkschmidt and B Dockhorn-Dworniczak and W Boecker",
year = "1999",
language = "Deutsch",
volume = "187",
pages = "396--402",
journal = "J PATHOL",
issn = "0022-3417",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.

AU - Buerger, H

AU - Otterbach, F

AU - Simon, Ronald

AU - Poremba, C

AU - Diallo, R

AU - Decker, T

AU - Riethdorf, L

AU - Brinkschmidt, C

AU - Dockhorn-Dworniczak, B

AU - Boecker, W

PY - 1999

Y1 - 1999

N2 - There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin-embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative genomic hybridization (CGH). Losses of 16q material were seen almost exclusively in well- and intermediately-differentiated DCIS. These two subgroups differed in the average number of genetic imbalances, 2.5 and 5.5 respectively. Additionally, a higher frequency of gains of 1q and losses of 11q material was seen in intermediately-differentiated in contrast to well-differentiated DCIS. Poorly-differentiated DCIS displayed a higher frequency of amplifications (17q12, 11q13) and a higher average rate of genetic imbalances (7.1). Analysis of adjacent invasive breast carcinoma revealed a genetic pattern almost identical to the one seen in the DCIS counterpart. These data characterize DCIS as a genetically far-advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer.

AB - There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin-embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative genomic hybridization (CGH). Losses of 16q material were seen almost exclusively in well- and intermediately-differentiated DCIS. These two subgroups differed in the average number of genetic imbalances, 2.5 and 5.5 respectively. Additionally, a higher frequency of gains of 1q and losses of 11q material was seen in intermediately-differentiated in contrast to well-differentiated DCIS. Poorly-differentiated DCIS displayed a higher frequency of amplifications (17q12, 11q13) and a higher average rate of genetic imbalances (7.1). Analysis of adjacent invasive breast carcinoma revealed a genetic pattern almost identical to the one seen in the DCIS counterpart. These data characterize DCIS as a genetically far-advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer.

M3 - SCORING: Zeitschriftenaufsatz

VL - 187

SP - 396

EP - 402

JO - J PATHOL

JF - J PATHOL

SN - 0022-3417

IS - 4

M1 - 4

ER -