Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.
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Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. / Buerger, H; Otterbach, F; Simon, Ronald; Poremba, C; Diallo, R; Decker, T; Riethdorf, L; Brinkschmidt, C; Dockhorn-Dworniczak, B; Boecker, W.
in: J PATHOL, Jahrgang 187, Nr. 4, 4, 1999, S. 396-402.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways.
AU - Buerger, H
AU - Otterbach, F
AU - Simon, Ronald
AU - Poremba, C
AU - Diallo, R
AU - Decker, T
AU - Riethdorf, L
AU - Brinkschmidt, C
AU - Dockhorn-Dworniczak, B
AU - Boecker, W
PY - 1999
Y1 - 1999
N2 - There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin-embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative genomic hybridization (CGH). Losses of 16q material were seen almost exclusively in well- and intermediately-differentiated DCIS. These two subgroups differed in the average number of genetic imbalances, 2.5 and 5.5 respectively. Additionally, a higher frequency of gains of 1q and losses of 11q material was seen in intermediately-differentiated in contrast to well-differentiated DCIS. Poorly-differentiated DCIS displayed a higher frequency of amplifications (17q12, 11q13) and a higher average rate of genetic imbalances (7.1). Analysis of adjacent invasive breast carcinoma revealed a genetic pattern almost identical to the one seen in the DCIS counterpart. These data characterize DCIS as a genetically far-advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer.
AB - There is strong evidence that ductal carcinoma in situ (DCIS) represents a precursor lesion of invasive breast cancer. In order to analyse specific chromosomal alterations of DCIS, 38 paraffin-embedded specimens of DCIS and six associated invasive carcinomas were examined by means of comparative genomic hybridization (CGH). Losses of 16q material were seen almost exclusively in well- and intermediately-differentiated DCIS. These two subgroups differed in the average number of genetic imbalances, 2.5 and 5.5 respectively. Additionally, a higher frequency of gains of 1q and losses of 11q material was seen in intermediately-differentiated in contrast to well-differentiated DCIS. Poorly-differentiated DCIS displayed a higher frequency of amplifications (17q12, 11q13) and a higher average rate of genetic imbalances (7.1). Analysis of adjacent invasive breast carcinoma revealed a genetic pattern almost identical to the one seen in the DCIS counterpart. These data characterize DCIS as a genetically far-advanced, heterogeneous lesion and as a direct precursor of invasive breast cancer.
M3 - SCORING: Zeitschriftenaufsatz
VL - 187
SP - 396
EP - 402
JO - J PATHOL
JF - J PATHOL
SN - 0022-3417
IS - 4
M1 - 4
ER -