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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. / Hollingworth, Paul; Harold, Denise; Sims, Rebecca; Gerrish, Amy; Lambert, Jean-Charles; Carrasquillo, Minerva M; Abraham, Richard; Hamshere, Marian L; Pahwa, Jaspreet Singh; Moskvina, Valentina; Dowzell, Kimberley; Jones, Nicola; Stretton, Alexandra; Thomas, Charlene; Richards, Alex; Ivanov, Dobril; Widdowson, Caroline; Chapman, Jade; Lovestone, Simon; Powell, John; Proitsi, Petroula; Lupton, Michelle K; Brayne, Carol; Rubinsztein, David C; Gill, Michael; Lawlor, Brian; Lynch, Aoibhinn; Brown, Kristelle S; Passmore, Peter A; Craig, David; McGuinness, Bernadette; Todd, Stephen; Holmes, Clive; Mann, David; Smith, A David; Beaumont, Helen; Warden, Donald; Wilcock, Gordon; Love, Seth; Kehoe, Patrick G; Hooper, Nigel M; Vardy, Emma R L C; Hardy, John; Mead, Simon; Fox, Nick C; Rossor, Martin; Collinge, John; Maier, Wolfgang; Jessen, Frank; Rüther, Eckart; Schürmann, Britta; Heun, Reiner; Kölsch, Heike; Bussche van den, Hendrik; Heuser, Isabella; Kornhuber, Johannes; Wiltfang, Jens; Dichgans, Martin; Frölich, Lutz; Hampel, Harald; Gallacher, John; Hüll, Michael; Rujescu, Dan; Giegling, Ina; Goate, Alison M; Kauwe, John S K; Cruchaga, Carlos; Nowotny, Petra; Morris, John C; Mayo, Kevin; Sleegers, Kristel; Bettens, Karolien; Engelborghs, Sebastiaan; Deyn, De; Peter, P; Christine, Van Broeckhoven; Livingston, Gill; Bass, Nicholas J; Gurling, Hugh; McQuillin, Andrew; Gwilliam, Rhian; Deloukas, Panagiotis; Al-Chalabi, Ammar; Shaw, Christopher E; Tsolaki, Magda; Singleton, Andrew B; Guerreiro, Rita; Mühleisen, Thomas W; Nöthen, Markus M; Moebus, Susanne; Jöckel, Karl-Heinz; Klopp, Norman; Wichmann, H-Erich; Pankratz, V Shane; Sando, Sigrid B; Aasly, Jan O; Barcikowska, Maria; Wszolek, Zbigniew K; Dickson, Dennis W; Graff-Radford, Neill R; Petersen, Ronald C; Initiative, Alzheimer's Disease Neuroimaging; Duijn, van; Cornelia, M; Breteler, Monique M B; Ikram, M Arfan; DeStefano, Anita L; Fitzpatrick, Annette L; Lopez, Oscar; Launer, Lenore J; Seshadri, Sudha; Consortium, CHARGE; Berr, Claudine; Campion, Dominique; Epelbaum, Jacques; Dartigues, Jean-François; Tzourio, Christophe; Alpérovitch, Annick; Lathrop, Mark; Feulner, Thomas M; Friedrich, Patricia; Riehle, Caterina; Krawczak, Michael; Schreiber, Stefan; Mayhaus, Manuel; Nicolhaus, S; Wagenpfeil, Stefan; Steinberg, Stacy; Stefansson, Hreinn; Stefansson, Kari; Snaedal, Jon; Björnsson, Sigurbjörn; Jonsson, Palmi V; Chouraki, Vincent; Genier-Boley, Benjamin; Hiltunen, Mikko; Soininen, Hilkka; Combarros, Onofre; Zelenika, Diana; Delepine, Marc; Bullido, Maria J; Pasquier, Florence; Mateo, Ignacio; Frank-Garcia, Ana; Porcellini, Elisa; Hanon, Olivier; Coto, Eliecer; Alvarez, Victoria; Bosco, Paolo; Siciliano, Gabriele; Mancuso, Michelangelo; Panza, Francesco; Solfrizzi, Vincenzo; Nacmias, Benedetta; Sorbi, Sandro; Bossù, Paola; Piccardi, Paola; Arosio, Beatrice; Annoni, Giorgio; Seripa, Davide; Pilotto, Alberto; Scarpini, Elio; Galimberti, Daniela; Brice, Alexis; Hannequin, Didier; Licastro, Federico; Jones, Lesley; Holmans, Peter A; Jonsson, Thorlakur; Riemenschneider, Matthias; Morgan, Kevin; Younkin, Steven G; Owen, Michael J; O'Donovan, Michael; Amouyel, Philippe; Williams, Julie.

In: NAT GENET, Vol. 43, No. 5, 5, 2011, p. 429-435.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hollingworth, P, Harold, D, Sims, R, Gerrish, A, Lambert, J-C, Carrasquillo, MM, Abraham, R, Hamshere, ML, Pahwa, JS, Moskvina, V, Dowzell, K, Jones, N, Stretton, A, Thomas, C, Richards, A, Ivanov, D, Widdowson, C, Chapman, J, Lovestone, S, Powell, J, Proitsi, P, Lupton, MK, Brayne, C, Rubinsztein, DC, Gill, M, Lawlor, B, Lynch, A, Brown, KS, Passmore, PA, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, AD, Beaumont, H, Warden, D, Wilcock, G, Love, S, Kehoe, PG, Hooper, NM, Vardy, ERLC, Hardy, J, Mead, S, Fox, NC, Rossor, M, Collinge, J, Maier, W, Jessen, F, Rüther, E, Schürmann, B, Heun, R, Kölsch, H, Bussche van den, H, Heuser, I, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Gallacher, J, Hüll, M, Rujescu, D, Giegling, I, Goate, AM, Kauwe, JSK, Cruchaga, C, Nowotny, P, Morris, JC, Mayo, K, Sleegers, K, Bettens, K, Engelborghs, S, Deyn, D, Peter, P, Christine, VB, Livingston, G, Bass, NJ, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, CE, Tsolaki, M, Singleton, AB, Guerreiro, R, Mühleisen, TW, Nöthen, MM, Moebus, S, Jöckel, K-H, Klopp, N, Wichmann, H-E, Pankratz, VS, Sando, SB, Aasly, JO, Barcikowska, M, Wszolek, ZK, Dickson, DW, Graff-Radford, NR, Petersen, RC, Initiative, ADN, Duijn, V, Cornelia, M, Breteler, MMB, Ikram, MA, DeStefano, AL, Fitzpatrick, AL, Lopez, O, Launer, LJ, Seshadri, S, Consortium, CHARGE, Berr, C, Campion, D, Epelbaum, J, Dartigues, J-F, Tzourio, C, Alpérovitch, A, Lathrop, M, Feulner, TM, Friedrich, P, Riehle, C, Krawczak, M, Schreiber, S, Mayhaus, M, Nicolhaus, S, Wagenpfeil, S, Steinberg, S, Stefansson, H, Stefansson, K, Snaedal, J, Björnsson, S, Jonsson, PV, Chouraki, V, Genier-Boley, B, Hiltunen, M, Soininen, H, Combarros, O, Zelenika, D, Delepine, M, Bullido, MJ, Pasquier, F, Mateo, I, Frank-Garcia, A, Porcellini, E, Hanon, O, Coto, E, Alvarez, V, Bosco, P, Siciliano, G, Mancuso, M, Panza, F, Solfrizzi, V, Nacmias, B, Sorbi, S, Bossù, P, Piccardi, P, Arosio, B, Annoni, G, Seripa, D, Pilotto, A, Scarpini, E, Galimberti, D, Brice, A, Hannequin, D, Licastro, F, Jones, L, Holmans, PA, Jonsson, T, Riemenschneider, M, Morgan, K, Younkin, SG, Owen, MJ, O'Donovan, M, Amouyel, P & Williams, J 2011, 'Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.', NAT GENET, vol. 43, no. 5, 5, pp. 429-435. <http://www.ncbi.nlm.nih.gov/pubmed/21460840?dopt=Citation>

APA

Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J-C., Carrasquillo, M. M., Abraham, R., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Jones, N., Stretton, A., Thomas, C., Richards, A., Ivanov, D., Widdowson, C., Chapman, J., Lovestone, S., ... Williams, J. (2011). Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. NAT GENET, 43(5), 429-435. [5]. http://www.ncbi.nlm.nih.gov/pubmed/21460840?dopt=Citation

Vancouver

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J-C, Carrasquillo MM et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. NAT GENET. 2011;43(5):429-435. 5.

Bibtex

@article{f541a92155a74965903d43577a6fc310,
title = "Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.",
abstract = "We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ? 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).",
keywords = "Humans, Male, Aged, Female, Aged, 80 and over, Multigene Family, Genetic Predisposition to Disease, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Case-Control Studies, Genetic Variation, ATP-Binding Cassette Transporters/*genetics, Adaptor Proteins, Signal Transducing/*genetics, Alzheimer Disease/*genetics, Antigens, CD/*genetics, Antigens, Differentiation, Myelomonocytic/*genetics, Cytoskeletal Proteins/*genetics, Databases, Genetic, Membrane Proteins/*genetics, Receptor, EphA1/*genetics, Humans, Male, Aged, Female, Aged, 80 and over, Multigene Family, Genetic Predisposition to Disease, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Case-Control Studies, Genetic Variation, ATP-Binding Cassette Transporters/*genetics, Adaptor Proteins, Signal Transducing/*genetics, Alzheimer Disease/*genetics, Antigens, CD/*genetics, Antigens, Differentiation, Myelomonocytic/*genetics, Cytoskeletal Proteins/*genetics, Databases, Genetic, Membrane Proteins/*genetics, Receptor, EphA1/*genetics",
author = "Paul Hollingworth and Denise Harold and Rebecca Sims and Amy Gerrish and Jean-Charles Lambert and Carrasquillo, {Minerva M} and Richard Abraham and Hamshere, {Marian L} and Pahwa, {Jaspreet Singh} and Valentina Moskvina and Kimberley Dowzell and Nicola Jones and Alexandra Stretton and Charlene Thomas and Alex Richards and Dobril Ivanov and Caroline Widdowson and Jade Chapman and Simon Lovestone and John Powell and Petroula Proitsi and Lupton, {Michelle K} and Carol Brayne and Rubinsztein, {David C} and Michael Gill and Brian Lawlor and Aoibhinn Lynch and Brown, {Kristelle S} and Passmore, {Peter A} and David Craig and Bernadette McGuinness and Stephen Todd and Clive Holmes and David Mann and Smith, {A David} and Helen Beaumont and Donald Warden and Gordon Wilcock and Seth Love and Kehoe, {Patrick G} and Hooper, {Nigel M} and Vardy, {Emma R L C} and John Hardy and Simon Mead and Fox, {Nick C} and Martin Rossor and John Collinge and Wolfgang Maier and Frank Jessen and Eckart R{\"u}ther and Britta Sch{\"u}rmann and Reiner Heun and Heike K{\"o}lsch and {Bussche van den}, Hendrik and Isabella Heuser and Johannes Kornhuber and Jens Wiltfang and Martin Dichgans and Lutz Fr{\"o}lich and Harald Hampel and John Gallacher and Michael H{\"u}ll and Dan Rujescu and Ina Giegling and Goate, {Alison M} and Kauwe, {John S K} and Carlos Cruchaga and Petra Nowotny and Morris, {John C} and Kevin Mayo and Kristel Sleegers and Karolien Bettens and Sebastiaan Engelborghs and De Deyn and P Peter and Christine, {Van Broeckhoven} and Gill Livingston and Bass, {Nicholas J} and Hugh Gurling and Andrew McQuillin and Rhian Gwilliam and Panagiotis Deloukas and Ammar Al-Chalabi and Shaw, {Christopher E} and Magda Tsolaki and Singleton, {Andrew B} and Rita Guerreiro and M{\"u}hleisen, {Thomas W} and N{\"o}then, {Markus M} and Susanne Moebus and Karl-Heinz J{\"o}ckel and Norman Klopp and H-Erich Wichmann and Pankratz, {V Shane} and Sando, {Sigrid B} and Aasly, {Jan O} and Maria Barcikowska and Wszolek, {Zbigniew K} and Dickson, {Dennis W} and Graff-Radford, {Neill R} and Petersen, {Ronald C} and Initiative, {Alzheimer's Disease Neuroimaging} and van Duijn and M Cornelia and Breteler, {Monique M B} and Ikram, {M Arfan} and DeStefano, {Anita L} and Fitzpatrick, {Annette L} and Oscar Lopez and Launer, {Lenore J} and Sudha Seshadri and CHARGE Consortium and Claudine Berr and Dominique Campion and Jacques Epelbaum and Jean-Fran{\c c}ois Dartigues and Christophe Tzourio and Annick Alp{\'e}rovitch and Mark Lathrop and Feulner, {Thomas M} and Patricia Friedrich and Caterina Riehle and Michael Krawczak and Stefan Schreiber and Manuel Mayhaus and S Nicolhaus and Stefan Wagenpfeil and Stacy Steinberg and Hreinn Stefansson and Kari Stefansson and Jon Snaedal and Sigurbj{\"o}rn Bj{\"o}rnsson and Jonsson, {Palmi V} and Vincent Chouraki and Benjamin Genier-Boley and Mikko Hiltunen and Hilkka Soininen and Onofre Combarros and Diana Zelenika and Marc Delepine and Bullido, {Maria J} and Florence Pasquier and Ignacio Mateo and Ana Frank-Garcia and Elisa Porcellini and Olivier Hanon and Eliecer Coto and Victoria Alvarez and Paolo Bosco and Gabriele Siciliano and Michelangelo Mancuso and Francesco Panza and Vincenzo Solfrizzi and Benedetta Nacmias and Sandro Sorbi and Paola Boss{\`u} and Paola Piccardi and Beatrice Arosio and Giorgio Annoni and Davide Seripa and Alberto Pilotto and Elio Scarpini and Daniela Galimberti and Alexis Brice and Didier Hannequin and Federico Licastro and Lesley Jones and Holmans, {Peter A} and Thorlakur Jonsson and Matthias Riemenschneider and Kevin Morgan and Younkin, {Steven G} and Owen, {Michael J} and Michael O'Donovan and Philippe Amouyel and Julie Williams",
year = "2011",
language = "English",
volume = "43",
pages = "429--435",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

AU - Hollingworth, Paul

AU - Harold, Denise

AU - Sims, Rebecca

AU - Gerrish, Amy

AU - Lambert, Jean-Charles

AU - Carrasquillo, Minerva M

AU - Abraham, Richard

AU - Hamshere, Marian L

AU - Pahwa, Jaspreet Singh

AU - Moskvina, Valentina

AU - Dowzell, Kimberley

AU - Jones, Nicola

AU - Stretton, Alexandra

AU - Thomas, Charlene

AU - Richards, Alex

AU - Ivanov, Dobril

AU - Widdowson, Caroline

AU - Chapman, Jade

AU - Lovestone, Simon

AU - Powell, John

AU - Proitsi, Petroula

AU - Lupton, Michelle K

AU - Brayne, Carol

AU - Rubinsztein, David C

AU - Gill, Michael

AU - Lawlor, Brian

AU - Lynch, Aoibhinn

AU - Brown, Kristelle S

AU - Passmore, Peter A

AU - Craig, David

AU - McGuinness, Bernadette

AU - Todd, Stephen

AU - Holmes, Clive

AU - Mann, David

AU - Smith, A David

AU - Beaumont, Helen

AU - Warden, Donald

AU - Wilcock, Gordon

AU - Love, Seth

AU - Kehoe, Patrick G

AU - Hooper, Nigel M

AU - Vardy, Emma R L C

AU - Hardy, John

AU - Mead, Simon

AU - Fox, Nick C

AU - Rossor, Martin

AU - Collinge, John

AU - Maier, Wolfgang

AU - Jessen, Frank

AU - Rüther, Eckart

AU - Schürmann, Britta

AU - Heun, Reiner

AU - Kölsch, Heike

AU - Bussche van den, Hendrik

AU - Heuser, Isabella

AU - Kornhuber, Johannes

AU - Wiltfang, Jens

AU - Dichgans, Martin

AU - Frölich, Lutz

AU - Hampel, Harald

AU - Gallacher, John

AU - Hüll, Michael

AU - Rujescu, Dan

AU - Giegling, Ina

AU - Goate, Alison M

AU - Kauwe, John S K

AU - Cruchaga, Carlos

AU - Nowotny, Petra

AU - Morris, John C

AU - Mayo, Kevin

AU - Sleegers, Kristel

AU - Bettens, Karolien

AU - Engelborghs, Sebastiaan

AU - Deyn, De

AU - Peter, P

AU - Christine, Van Broeckhoven

AU - Livingston, Gill

AU - Bass, Nicholas J

AU - Gurling, Hugh

AU - McQuillin, Andrew

AU - Gwilliam, Rhian

AU - Deloukas, Panagiotis

AU - Al-Chalabi, Ammar

AU - Shaw, Christopher E

AU - Tsolaki, Magda

AU - Singleton, Andrew B

AU - Guerreiro, Rita

AU - Mühleisen, Thomas W

AU - Nöthen, Markus M

AU - Moebus, Susanne

AU - Jöckel, Karl-Heinz

AU - Klopp, Norman

AU - Wichmann, H-Erich

AU - Pankratz, V Shane

AU - Sando, Sigrid B

AU - Aasly, Jan O

AU - Barcikowska, Maria

AU - Wszolek, Zbigniew K

AU - Dickson, Dennis W

AU - Graff-Radford, Neill R

AU - Petersen, Ronald C

AU - Initiative, Alzheimer's Disease Neuroimaging

AU - Duijn, van

AU - Cornelia, M

AU - Breteler, Monique M B

AU - Ikram, M Arfan

AU - DeStefano, Anita L

AU - Fitzpatrick, Annette L

AU - Lopez, Oscar

AU - Launer, Lenore J

AU - Seshadri, Sudha

AU - Consortium, CHARGE

AU - Berr, Claudine

AU - Campion, Dominique

AU - Epelbaum, Jacques

AU - Dartigues, Jean-François

AU - Tzourio, Christophe

AU - Alpérovitch, Annick

AU - Lathrop, Mark

AU - Feulner, Thomas M

AU - Friedrich, Patricia

AU - Riehle, Caterina

AU - Krawczak, Michael

AU - Schreiber, Stefan

AU - Mayhaus, Manuel

AU - Nicolhaus, S

AU - Wagenpfeil, Stefan

AU - Steinberg, Stacy

AU - Stefansson, Hreinn

AU - Stefansson, Kari

AU - Snaedal, Jon

AU - Björnsson, Sigurbjörn

AU - Jonsson, Palmi V

AU - Chouraki, Vincent

AU - Genier-Boley, Benjamin

AU - Hiltunen, Mikko

AU - Soininen, Hilkka

AU - Combarros, Onofre

AU - Zelenika, Diana

AU - Delepine, Marc

AU - Bullido, Maria J

AU - Pasquier, Florence

AU - Mateo, Ignacio

AU - Frank-Garcia, Ana

AU - Porcellini, Elisa

AU - Hanon, Olivier

AU - Coto, Eliecer

AU - Alvarez, Victoria

AU - Bosco, Paolo

AU - Siciliano, Gabriele

AU - Mancuso, Michelangelo

AU - Panza, Francesco

AU - Solfrizzi, Vincenzo

AU - Nacmias, Benedetta

AU - Sorbi, Sandro

AU - Bossù, Paola

AU - Piccardi, Paola

AU - Arosio, Beatrice

AU - Annoni, Giorgio

AU - Seripa, Davide

AU - Pilotto, Alberto

AU - Scarpini, Elio

AU - Galimberti, Daniela

AU - Brice, Alexis

AU - Hannequin, Didier

AU - Licastro, Federico

AU - Jones, Lesley

AU - Holmans, Peter A

AU - Jonsson, Thorlakur

AU - Riemenschneider, Matthias

AU - Morgan, Kevin

AU - Younkin, Steven G

AU - Owen, Michael J

AU - O'Donovan, Michael

AU - Amouyel, Philippe

AU - Williams, Julie

PY - 2011

Y1 - 2011

N2 - We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ? 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).

AB - We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ? 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Aged, 80 and over

KW - Multigene Family

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Polymorphism, Single Nucleotide

KW - Case-Control Studies

KW - Genetic Variation

KW - ATP-Binding Cassette Transporters/genetics

KW - Adaptor Proteins, Signal Transducing/genetics

KW - Alzheimer Disease/genetics

KW - Antigens, CD/genetics

KW - Antigens, Differentiation, Myelomonocytic/genetics

KW - Cytoskeletal Proteins/genetics

KW - Databases, Genetic

KW - Membrane Proteins/genetics

KW - Receptor, EphA1/genetics

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Aged, 80 and over

KW - Multigene Family

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Polymorphism, Single Nucleotide

KW - Case-Control Studies

KW - Genetic Variation

KW - ATP-Binding Cassette Transporters/genetics

KW - Adaptor Proteins, Signal Transducing/genetics

KW - Alzheimer Disease/genetics

KW - Antigens, CD/genetics

KW - Antigens, Differentiation, Myelomonocytic/genetics

KW - Cytoskeletal Proteins/genetics

KW - Databases, Genetic

KW - Membrane Proteins/genetics

KW - Receptor, EphA1/genetics

M3 - SCORING: Journal article

VL - 43

SP - 429

EP - 435

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 5

M1 - 5

ER -