Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. / Hollingworth, Paul; Harold, Denise; Sims, Rebecca; Gerrish, Amy; Lambert, Jean-Charles; Carrasquillo, Minerva M; Abraham, Richard; Hamshere, Marian L; Pahwa, Jaspreet Singh; Moskvina, Valentina; Dowzell, Kimberley; Jones, Nicola; Stretton, Alexandra; Thomas, Charlene; Richards, Alex; Ivanov, Dobril; Widdowson, Caroline; Chapman, Jade; Lovestone, Simon; Powell, John; Proitsi, Petroula; Lupton, Michelle K; Brayne, Carol; Rubinsztein, David C; Gill, Michael; Lawlor, Brian; Lynch, Aoibhinn; Brown, Kristelle S; Passmore, Peter A; Craig, David; McGuinness, Bernadette; Todd, Stephen; Holmes, Clive; Mann, David; Smith, A David; Beaumont, Helen; Warden, Donald; Wilcock, Gordon; Love, Seth; Kehoe, Patrick G; Hooper, Nigel M; Vardy, Emma R L C; Hardy, John; Mead, Simon; Fox, Nick C; Rossor, Martin; Collinge, John; Maier, Wolfgang; Jessen, Frank; Rüther, Eckart; Schürmann, Britta; Heun, Reiner; Kölsch, Heike; Bussche van den, Hendrik; Heuser, Isabella; Kornhuber, Johannes; Wiltfang, Jens; Dichgans, Martin; Frölich, Lutz; Hampel, Harald; Gallacher, John; Hüll, Michael; Rujescu, Dan; Giegling, Ina; Goate, Alison M; Kauwe, John S K; Cruchaga, Carlos; Nowotny, Petra; Morris, John C; Mayo, Kevin; Sleegers, Kristel; Bettens, Karolien; Engelborghs, Sebastiaan; Deyn, De; Peter, P; Christine, Van Broeckhoven; Livingston, Gill; Bass, Nicholas J; Gurling, Hugh; McQuillin, Andrew; Gwilliam, Rhian; Deloukas, Panagiotis; Al-Chalabi, Ammar; Shaw, Christopher E; Tsolaki, Magda; Singleton, Andrew B; Guerreiro, Rita; Mühleisen, Thomas W; Nöthen, Markus M; Moebus, Susanne; Jöckel, Karl-Heinz; Klopp, Norman; Wichmann, H-Erich; Pankratz, V Shane; Sando, Sigrid B; Aasly, Jan O; Barcikowska, Maria; Wszolek, Zbigniew K; Dickson, Dennis W; Graff-Radford, Neill R; Petersen, Ronald C; Initiative, Alzheimer's Disease Neuroimaging; Duijn, van; Cornelia, M; Breteler, Monique M B; Ikram, M Arfan; DeStefano, Anita L; Fitzpatrick, Annette L; Lopez, Oscar; Launer, Lenore J; Seshadri, Sudha; Consortium, CHARGE; Berr, Claudine; Campion, Dominique; Epelbaum, Jacques; Dartigues, Jean-François; Tzourio, Christophe; Alpérovitch, Annick; Lathrop, Mark; Feulner, Thomas M; Friedrich, Patricia; Riehle, Caterina; Krawczak, Michael; Schreiber, Stefan; Mayhaus, Manuel; Nicolhaus, S; Wagenpfeil, Stefan; Steinberg, Stacy; Stefansson, Hreinn; Stefansson, Kari; Snaedal, Jon; Björnsson, Sigurbjörn; Jonsson, Palmi V; Chouraki, Vincent; Genier-Boley, Benjamin; Hiltunen, Mikko; Soininen, Hilkka; Combarros, Onofre; Zelenika, Diana; Delepine, Marc; Bullido, Maria J; Pasquier, Florence; Mateo, Ignacio; Frank-Garcia, Ana; Porcellini, Elisa; Hanon, Olivier; Coto, Eliecer; Alvarez, Victoria; Bosco, Paolo; Siciliano, Gabriele; Mancuso, Michelangelo; Panza, Francesco; Solfrizzi, Vincenzo; Nacmias, Benedetta; Sorbi, Sandro; Bossù, Paola; Piccardi, Paola; Arosio, Beatrice; Annoni, Giorgio; Seripa, Davide; Pilotto, Alberto; Scarpini, Elio; Galimberti, Daniela; Brice, Alexis; Hannequin, Didier; Licastro, Federico; Jones, Lesley; Holmans, Peter A; Jonsson, Thorlakur; Riemenschneider, Matthias; Morgan, Kevin; Younkin, Steven G; Owen, Michael J; O'Donovan, Michael; Amouyel, Philippe; Williams, Julie.
in: NAT GENET, Jahrgang 43, Nr. 5, 5, 2011, S. 429-435.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
AU - Hollingworth, Paul
AU - Harold, Denise
AU - Sims, Rebecca
AU - Gerrish, Amy
AU - Lambert, Jean-Charles
AU - Carrasquillo, Minerva M
AU - Abraham, Richard
AU - Hamshere, Marian L
AU - Pahwa, Jaspreet Singh
AU - Moskvina, Valentina
AU - Dowzell, Kimberley
AU - Jones, Nicola
AU - Stretton, Alexandra
AU - Thomas, Charlene
AU - Richards, Alex
AU - Ivanov, Dobril
AU - Widdowson, Caroline
AU - Chapman, Jade
AU - Lovestone, Simon
AU - Powell, John
AU - Proitsi, Petroula
AU - Lupton, Michelle K
AU - Brayne, Carol
AU - Rubinsztein, David C
AU - Gill, Michael
AU - Lawlor, Brian
AU - Lynch, Aoibhinn
AU - Brown, Kristelle S
AU - Passmore, Peter A
AU - Craig, David
AU - McGuinness, Bernadette
AU - Todd, Stephen
AU - Holmes, Clive
AU - Mann, David
AU - Smith, A David
AU - Beaumont, Helen
AU - Warden, Donald
AU - Wilcock, Gordon
AU - Love, Seth
AU - Kehoe, Patrick G
AU - Hooper, Nigel M
AU - Vardy, Emma R L C
AU - Hardy, John
AU - Mead, Simon
AU - Fox, Nick C
AU - Rossor, Martin
AU - Collinge, John
AU - Maier, Wolfgang
AU - Jessen, Frank
AU - Rüther, Eckart
AU - Schürmann, Britta
AU - Heun, Reiner
AU - Kölsch, Heike
AU - Bussche van den, Hendrik
AU - Heuser, Isabella
AU - Kornhuber, Johannes
AU - Wiltfang, Jens
AU - Dichgans, Martin
AU - Frölich, Lutz
AU - Hampel, Harald
AU - Gallacher, John
AU - Hüll, Michael
AU - Rujescu, Dan
AU - Giegling, Ina
AU - Goate, Alison M
AU - Kauwe, John S K
AU - Cruchaga, Carlos
AU - Nowotny, Petra
AU - Morris, John C
AU - Mayo, Kevin
AU - Sleegers, Kristel
AU - Bettens, Karolien
AU - Engelborghs, Sebastiaan
AU - Deyn, De
AU - Peter, P
AU - Christine, Van Broeckhoven
AU - Livingston, Gill
AU - Bass, Nicholas J
AU - Gurling, Hugh
AU - McQuillin, Andrew
AU - Gwilliam, Rhian
AU - Deloukas, Panagiotis
AU - Al-Chalabi, Ammar
AU - Shaw, Christopher E
AU - Tsolaki, Magda
AU - Singleton, Andrew B
AU - Guerreiro, Rita
AU - Mühleisen, Thomas W
AU - Nöthen, Markus M
AU - Moebus, Susanne
AU - Jöckel, Karl-Heinz
AU - Klopp, Norman
AU - Wichmann, H-Erich
AU - Pankratz, V Shane
AU - Sando, Sigrid B
AU - Aasly, Jan O
AU - Barcikowska, Maria
AU - Wszolek, Zbigniew K
AU - Dickson, Dennis W
AU - Graff-Radford, Neill R
AU - Petersen, Ronald C
AU - Initiative, Alzheimer's Disease Neuroimaging
AU - Duijn, van
AU - Cornelia, M
AU - Breteler, Monique M B
AU - Ikram, M Arfan
AU - DeStefano, Anita L
AU - Fitzpatrick, Annette L
AU - Lopez, Oscar
AU - Launer, Lenore J
AU - Seshadri, Sudha
AU - Consortium, CHARGE
AU - Berr, Claudine
AU - Campion, Dominique
AU - Epelbaum, Jacques
AU - Dartigues, Jean-François
AU - Tzourio, Christophe
AU - Alpérovitch, Annick
AU - Lathrop, Mark
AU - Feulner, Thomas M
AU - Friedrich, Patricia
AU - Riehle, Caterina
AU - Krawczak, Michael
AU - Schreiber, Stefan
AU - Mayhaus, Manuel
AU - Nicolhaus, S
AU - Wagenpfeil, Stefan
AU - Steinberg, Stacy
AU - Stefansson, Hreinn
AU - Stefansson, Kari
AU - Snaedal, Jon
AU - Björnsson, Sigurbjörn
AU - Jonsson, Palmi V
AU - Chouraki, Vincent
AU - Genier-Boley, Benjamin
AU - Hiltunen, Mikko
AU - Soininen, Hilkka
AU - Combarros, Onofre
AU - Zelenika, Diana
AU - Delepine, Marc
AU - Bullido, Maria J
AU - Pasquier, Florence
AU - Mateo, Ignacio
AU - Frank-Garcia, Ana
AU - Porcellini, Elisa
AU - Hanon, Olivier
AU - Coto, Eliecer
AU - Alvarez, Victoria
AU - Bosco, Paolo
AU - Siciliano, Gabriele
AU - Mancuso, Michelangelo
AU - Panza, Francesco
AU - Solfrizzi, Vincenzo
AU - Nacmias, Benedetta
AU - Sorbi, Sandro
AU - Bossù, Paola
AU - Piccardi, Paola
AU - Arosio, Beatrice
AU - Annoni, Giorgio
AU - Seripa, Davide
AU - Pilotto, Alberto
AU - Scarpini, Elio
AU - Galimberti, Daniela
AU - Brice, Alexis
AU - Hannequin, Didier
AU - Licastro, Federico
AU - Jones, Lesley
AU - Holmans, Peter A
AU - Jonsson, Thorlakur
AU - Riemenschneider, Matthias
AU - Morgan, Kevin
AU - Younkin, Steven G
AU - Owen, Michael J
AU - O'Donovan, Michael
AU - Amouyel, Philippe
AU - Williams, Julie
PY - 2011
Y1 - 2011
N2 - We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ? 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).
AB - We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ? 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Aged, 80 and over
KW - Multigene Family
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Polymorphism, Single Nucleotide
KW - Case-Control Studies
KW - Genetic Variation
KW - ATP-Binding Cassette Transporters/genetics
KW - Adaptor Proteins, Signal Transducing/genetics
KW - Alzheimer Disease/genetics
KW - Antigens, CD/genetics
KW - Antigens, Differentiation, Myelomonocytic/genetics
KW - Cytoskeletal Proteins/genetics
KW - Databases, Genetic
KW - Membrane Proteins/genetics
KW - Receptor, EphA1/genetics
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Aged, 80 and over
KW - Multigene Family
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Polymorphism, Single Nucleotide
KW - Case-Control Studies
KW - Genetic Variation
KW - ATP-Binding Cassette Transporters/genetics
KW - Adaptor Proteins, Signal Transducing/genetics
KW - Alzheimer Disease/genetics
KW - Antigens, CD/genetics
KW - Antigens, Differentiation, Myelomonocytic/genetics
KW - Cytoskeletal Proteins/genetics
KW - Databases, Genetic
KW - Membrane Proteins/genetics
KW - Receptor, EphA1/genetics
M3 - SCORING: Journal article
VL - 43
SP - 429
EP - 435
JO - NAT GENET
JF - NAT GENET
SN - 1061-4036
IS - 5
M1 - 5
ER -