Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling
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Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling. / Salmani Rahimi, Mahdi; Korosec, Frank R; Wang, Kang; Holmes, James H; Motosugi, Utaroh; Bannas, Peter; Reeder, Scott B.
In: MAGN RESON MED, Vol. 73, No. 3, 03.2015, p. 973-83.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling
AU - Salmani Rahimi, Mahdi
AU - Korosec, Frank R
AU - Wang, Kang
AU - Holmes, James H
AU - Motosugi, Utaroh
AU - Bannas, Peter
AU - Reeder, Scott B
N1 - © 2014 Wiley Periodicals, Inc.
PY - 2015/3
Y1 - 2015/3
N2 - PURPOSE: To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent.METHODS: An interleaved variable density (IVD) undersampling pattern was implemented in combination with a real-time-triggered, time-resolved, dual-echo 3D spoiled gradient echo sequence. Parallel imaging autocalibration lines were acquired only once during the first time frame. Imaging was performed in 10 subjects with focal nodular hyperplasia (FNH) and compared with their clinical MRI. The angiographic phase of the proposed method was compared with a dedicated MR angiogram acquired during a second injection of contrast.RESULTS: A total of 21 FNH, three cavernous hemangiomas, and 109 arterial segments were visualized in 10 subjects. The temporally resolved images depicted the characteristic arterial enhancement pattern of the lesions with a 4-s update rate. Images were graded as having significantly higher quality compared with the clinical MRI. Angiograms produced from the IVD method provided noninferior diagnostic assessment compared with the dedicated MR angiogram.CONCLUSION: Using an undersampled IVD imaging method, we have demonstrated the feasibility of obtaining high spatial and temporal resolution dynamic contrast-enhanced imaging and simultaneous MRA of the liver.
AB - PURPOSE: To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent.METHODS: An interleaved variable density (IVD) undersampling pattern was implemented in combination with a real-time-triggered, time-resolved, dual-echo 3D spoiled gradient echo sequence. Parallel imaging autocalibration lines were acquired only once during the first time frame. Imaging was performed in 10 subjects with focal nodular hyperplasia (FNH) and compared with their clinical MRI. The angiographic phase of the proposed method was compared with a dedicated MR angiogram acquired during a second injection of contrast.RESULTS: A total of 21 FNH, three cavernous hemangiomas, and 109 arterial segments were visualized in 10 subjects. The temporally resolved images depicted the characteristic arterial enhancement pattern of the lesions with a 4-s update rate. Images were graded as having significantly higher quality compared with the clinical MRI. Angiograms produced from the IVD method provided noninferior diagnostic assessment compared with the dedicated MR angiogram.CONCLUSION: Using an undersampled IVD imaging method, we have demonstrated the feasibility of obtaining high spatial and temporal resolution dynamic contrast-enhanced imaging and simultaneous MRA of the liver.
KW - Adult
KW - Algorithms
KW - Contrast Media
KW - Data Interpretation, Statistical
KW - Female
KW - Hemangioma, Cavernous, Central Nervous System
KW - Humans
KW - Image Enhancement
KW - Image Interpretation, Computer-Assisted
KW - Imaging, Three-Dimensional
KW - Liver Neoplasms
KW - Magnetic Resonance Angiography
KW - Male
KW - Meglumine
KW - Organometallic Compounds
KW - Reproducibility of Results
KW - Sample Size
KW - Sensitivity and Specificity
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/mrm.25195
DO - 10.1002/mrm.25195
M3 - SCORING: Journal article
C2 - 24639130
VL - 73
SP - 973
EP - 983
JO - MAGN RESON MED
JF - MAGN RESON MED
SN - 0740-3194
IS - 3
ER -