Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling

TY - JOUR

T1 - Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling

AU - Salmani Rahimi, Mahdi

AU - Korosec, Frank R

AU - Wang, Kang

AU - Holmes, James H

AU - Motosugi, Utaroh

AU - Bannas, Peter

AU - Reeder, Scott B

N1 - © 2014 Wiley Periodicals, Inc.

PY - 2015/3

Y1 - 2015/3

N2 - PURPOSE: To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent.METHODS: An interleaved variable density (IVD) undersampling pattern was implemented in combination with a real-time-triggered, time-resolved, dual-echo 3D spoiled gradient echo sequence. Parallel imaging autocalibration lines were acquired only once during the first time frame. Imaging was performed in 10 subjects with focal nodular hyperplasia (FNH) and compared with their clinical MRI. The angiographic phase of the proposed method was compared with a dedicated MR angiogram acquired during a second injection of contrast.RESULTS: A total of 21 FNH, three cavernous hemangiomas, and 109 arterial segments were visualized in 10 subjects. The temporally resolved images depicted the characteristic arterial enhancement pattern of the lesions with a 4-s update rate. Images were graded as having significantly higher quality compared with the clinical MRI. Angiograms produced from the IVD method provided noninferior diagnostic assessment compared with the dedicated MR angiogram.CONCLUSION: Using an undersampled IVD imaging method, we have demonstrated the feasibility of obtaining high spatial and temporal resolution dynamic contrast-enhanced imaging and simultaneous MRA of the liver.

AB - PURPOSE: To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent.METHODS: An interleaved variable density (IVD) undersampling pattern was implemented in combination with a real-time-triggered, time-resolved, dual-echo 3D spoiled gradient echo sequence. Parallel imaging autocalibration lines were acquired only once during the first time frame. Imaging was performed in 10 subjects with focal nodular hyperplasia (FNH) and compared with their clinical MRI. The angiographic phase of the proposed method was compared with a dedicated MR angiogram acquired during a second injection of contrast.RESULTS: A total of 21 FNH, three cavernous hemangiomas, and 109 arterial segments were visualized in 10 subjects. The temporally resolved images depicted the characteristic arterial enhancement pattern of the lesions with a 4-s update rate. Images were graded as having significantly higher quality compared with the clinical MRI. Angiograms produced from the IVD method provided noninferior diagnostic assessment compared with the dedicated MR angiogram.CONCLUSION: Using an undersampled IVD imaging method, we have demonstrated the feasibility of obtaining high spatial and temporal resolution dynamic contrast-enhanced imaging and simultaneous MRA of the liver.

KW - Adult

KW - Algorithms

KW - Contrast Media

KW - Data Interpretation, Statistical

KW - Female

KW - Hemangioma, Cavernous, Central Nervous System

KW - Humans

KW - Image Enhancement

KW - Image Interpretation, Computer-Assisted

KW - Imaging, Three-Dimensional

KW - Liver Neoplasms

KW - Magnetic Resonance Angiography

KW - Male

KW - Meglumine

KW - Organometallic Compounds

KW - Reproducibility of Results

KW - Sample Size

KW - Sensitivity and Specificity

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/mrm.25195

DO - 10.1002/mrm.25195

M3 - SCORING: Journal article

C2 - 24639130

VL - 73

SP - 973

EP - 983

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 3

ER -