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Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland

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Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland. / Schlüter, H; Meissner, M; van der Giet, M; Tepel, M; Bachmann, J; Gross, I; Nordhoff, E; Karas, M; Spieker, C; Witzel, H.

In: CIRC RES, Vol. 76, No. 4, 04.1995, p. 675-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schlüter, H, Meissner, M, van der Giet, M, Tepel, M, Bachmann, J, Gross, I, Nordhoff, E, Karas, M, Spieker, C & Witzel, H 1995, 'Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland', CIRC RES, vol. 76, no. 4, pp. 675-80.

APA

Schlüter, H., Meissner, M., van der Giet, M., Tepel, M., Bachmann, J., Gross, I., Nordhoff, E., Karas, M., Spieker, C., & Witzel, H. (1995). Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland. CIRC RES, 76(4), 675-80.

Vancouver

Schlüter H, Meissner M, van der Giet M, Tepel M, Bachmann J, Gross I et al. Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland. CIRC RES. 1995 Apr;76(4):675-80.

Bibtex

@article{932c7e325bcc4067ba94fe7771106447,
title = "Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland",
abstract = "The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain. A further potent vasoconstrictor is isolated from bovine adrenal glands and is identified by chromatography, mass spectrometry, UV spectroscopy, and enzymatic cleavage as coenzyme A glutathione disulfide (CoASSG). CoASSG is found in chromaffin granules of adrenal glands and is released from adrenal medulla slices by carbachol. At a concentration of 10(-12) mol/L CoASSG increases renal vascular resistance. Intra-aortic injection of 5 x 10(-10) mol CoASSG increases blood pressure in the intact animal. Besides its vasopressor properties, this substance potentiates the effects of angiotensin II on vascular tone. It is concluded that CoASSG could play a role in blood pressure regulation not only by direct effects but also by modulation of the action of angiotensin II.",
keywords = "Adrenal Glands, Adrenal Medulla, Animals, Blood Pressure, Calcium, Carbachol, Cattle, Chromaffin Granules, Chromatography, High Pressure Liquid, Coenzyme A, Hemodynamics, In Vitro Techniques, Kidney, Mass Spectrometry, Muscle, Smooth, Vascular, Perfusion, Rats, Spectrophotometry, Ultraviolet, Stimulation, Chemical, Vascular Resistance, Vasoconstrictor Agents, Journal Article, Research Support, Non-U.S. Gov't",
author = "H Schl{\"u}ter and M Meissner and {van der Giet}, M and M Tepel and J Bachmann and I Gross and E Nordhoff and M Karas and C Spieker and H Witzel",
year = "1995",
month = apr,
language = "English",
volume = "76",
pages = "675--80",
journal = "CIRC RES",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland

AU - Schlüter, H

AU - Meissner, M

AU - van der Giet, M

AU - Tepel, M

AU - Bachmann, J

AU - Gross, I

AU - Nordhoff, E

AU - Karas, M

AU - Spieker, C

AU - Witzel, H

PY - 1995/4

Y1 - 1995/4

N2 - The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain. A further potent vasoconstrictor is isolated from bovine adrenal glands and is identified by chromatography, mass spectrometry, UV spectroscopy, and enzymatic cleavage as coenzyme A glutathione disulfide (CoASSG). CoASSG is found in chromaffin granules of adrenal glands and is released from adrenal medulla slices by carbachol. At a concentration of 10(-12) mol/L CoASSG increases renal vascular resistance. Intra-aortic injection of 5 x 10(-10) mol CoASSG increases blood pressure in the intact animal. Besides its vasopressor properties, this substance potentiates the effects of angiotensin II on vascular tone. It is concluded that CoASSG could play a role in blood pressure regulation not only by direct effects but also by modulation of the action of angiotensin II.

AB - The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain. A further potent vasoconstrictor is isolated from bovine adrenal glands and is identified by chromatography, mass spectrometry, UV spectroscopy, and enzymatic cleavage as coenzyme A glutathione disulfide (CoASSG). CoASSG is found in chromaffin granules of adrenal glands and is released from adrenal medulla slices by carbachol. At a concentration of 10(-12) mol/L CoASSG increases renal vascular resistance. Intra-aortic injection of 5 x 10(-10) mol CoASSG increases blood pressure in the intact animal. Besides its vasopressor properties, this substance potentiates the effects of angiotensin II on vascular tone. It is concluded that CoASSG could play a role in blood pressure regulation not only by direct effects but also by modulation of the action of angiotensin II.

KW - Adrenal Glands

KW - Adrenal Medulla

KW - Animals

KW - Blood Pressure

KW - Calcium

KW - Carbachol

KW - Cattle

KW - Chromaffin Granules

KW - Chromatography, High Pressure Liquid

KW - Coenzyme A

KW - Hemodynamics

KW - In Vitro Techniques

KW - Kidney

KW - Mass Spectrometry

KW - Muscle, Smooth, Vascular

KW - Perfusion

KW - Rats

KW - Spectrophotometry, Ultraviolet

KW - Stimulation, Chemical

KW - Vascular Resistance

KW - Vasoconstrictor Agents

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 7895341

VL - 76

SP - 675

EP - 680

JO - CIRC RES

JF - CIRC RES

SN - 0009-7330

IS - 4

ER -