Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland
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Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland. / Schlüter, H; Meissner, M; van der Giet, M; Tepel, M; Bachmann, J; Gross, I; Nordhoff, E; Karas, M; Spieker, C; Witzel, H.
in: CIRC RES, Jahrgang 76, Nr. 4, 04.1995, S. 675-80.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland
AU - Schlüter, H
AU - Meissner, M
AU - van der Giet, M
AU - Tepel, M
AU - Bachmann, J
AU - Gross, I
AU - Nordhoff, E
AU - Karas, M
AU - Spieker, C
AU - Witzel, H
PY - 1995/4
Y1 - 1995/4
N2 - The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain. A further potent vasoconstrictor is isolated from bovine adrenal glands and is identified by chromatography, mass spectrometry, UV spectroscopy, and enzymatic cleavage as coenzyme A glutathione disulfide (CoASSG). CoASSG is found in chromaffin granules of adrenal glands and is released from adrenal medulla slices by carbachol. At a concentration of 10(-12) mol/L CoASSG increases renal vascular resistance. Intra-aortic injection of 5 x 10(-10) mol CoASSG increases blood pressure in the intact animal. Besides its vasopressor properties, this substance potentiates the effects of angiotensin II on vascular tone. It is concluded that CoASSG could play a role in blood pressure regulation not only by direct effects but also by modulation of the action of angiotensin II.
AB - The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain. A further potent vasoconstrictor is isolated from bovine adrenal glands and is identified by chromatography, mass spectrometry, UV spectroscopy, and enzymatic cleavage as coenzyme A glutathione disulfide (CoASSG). CoASSG is found in chromaffin granules of adrenal glands and is released from adrenal medulla slices by carbachol. At a concentration of 10(-12) mol/L CoASSG increases renal vascular resistance. Intra-aortic injection of 5 x 10(-10) mol CoASSG increases blood pressure in the intact animal. Besides its vasopressor properties, this substance potentiates the effects of angiotensin II on vascular tone. It is concluded that CoASSG could play a role in blood pressure regulation not only by direct effects but also by modulation of the action of angiotensin II.
KW - Adrenal Glands
KW - Adrenal Medulla
KW - Animals
KW - Blood Pressure
KW - Calcium
KW - Carbachol
KW - Cattle
KW - Chromaffin Granules
KW - Chromatography, High Pressure Liquid
KW - Coenzyme A
KW - Hemodynamics
KW - In Vitro Techniques
KW - Kidney
KW - Mass Spectrometry
KW - Muscle, Smooth, Vascular
KW - Perfusion
KW - Rats
KW - Spectrophotometry, Ultraviolet
KW - Stimulation, Chemical
KW - Vascular Resistance
KW - Vasoconstrictor Agents
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - SCORING: Journal article
C2 - 7895341
VL - 76
SP - 675
EP - 680
JO - CIRC RES
JF - CIRC RES
SN - 0009-7330
IS - 4
ER -