Cloning of a novel glutamate receptor subunit, GluR5
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Cloning of a novel glutamate receptor subunit, GluR5 : expression in the nervous system during development. / Bettler, B; Boulter, J; Hermans-Borgmeyer, I; O'Shea-Greenfield, A; Deneris, E S; Moll, C; Borgmeyer, U; Hollmann, M; Heinemann, S.
In: NEURON, Vol. 5, No. 5, 11.1990, p. 583-95.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cloning of a novel glutamate receptor subunit, GluR5
T2 - expression in the nervous system during development
AU - Bettler, B
AU - Boulter, J
AU - Hermans-Borgmeyer, I
AU - O'Shea-Greenfield, A
AU - Deneris, E S
AU - Moll, C
AU - Borgmeyer, U
AU - Hollmann, M
AU - Heinemann, S
PY - 1990/11
Y1 - 1990/11
N2 - We have isolated cDNAs encoding a glutamate receptor subunit, designated GluR5, displaying 40%-41% amino acid identity with the kainate/AMPA receptor subunits GluR1, GluR2, GluR3, and GluR4. This level of sequence similarity is significantly below the approximately 70% intersubunit identity characteristic of kainate/AMPA receptors. The GluR5 protein forms homomeric ion channels in Xenopus oocytes that are weakly responsive to L-glutamate. The GluR5 gene is expressed in subsets of neurons throughout the developing and adult central and peripheral nervous systems. During embryogenesis, GluR5 transcripts are detected in areas of neuronal differentiation and synapse formation.
AB - We have isolated cDNAs encoding a glutamate receptor subunit, designated GluR5, displaying 40%-41% amino acid identity with the kainate/AMPA receptor subunits GluR1, GluR2, GluR3, and GluR4. This level of sequence similarity is significantly below the approximately 70% intersubunit identity characteristic of kainate/AMPA receptors. The GluR5 protein forms homomeric ion channels in Xenopus oocytes that are weakly responsive to L-glutamate. The GluR5 gene is expressed in subsets of neurons throughout the developing and adult central and peripheral nervous systems. During embryogenesis, GluR5 transcripts are detected in areas of neuronal differentiation and synapse formation.
KW - Aging
KW - Animals
KW - Base Sequence
KW - Central Nervous System
KW - Cloning, Molecular
KW - Gene Expression Regulation
KW - Genes
KW - Glutamates
KW - Glutamic Acid
KW - In Vitro Techniques
KW - Oocytes
KW - Peripheral Nerves
KW - Receptors, Glutamate
KW - Receptors, Neurotransmitter
KW - Xenopus
M3 - SCORING: Journal article
C2 - 1977421
VL - 5
SP - 583
EP - 595
JO - NEURON
JF - NEURON
SN - 0896-6273
IS - 5
ER -