Clinical risk factors of oral leukoplakia in a representative sample of the US population

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Clinical risk factors of oral leukoplakia in a representative sample of the US population. / Dietrich, Thomas; Reichart, Peter A; Scheifele, Christian.

In: ORAL ONCOL, Vol. 40, No. 2, 01.02.2004, p. 158-63.

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@article{af312c240f394ca4b7853887f4b4888c,
title = "Clinical risk factors of oral leukoplakia in a representative sample of the US population",
abstract = "Studies on the risk factors of oral leukoplakia (OL) are relatively scarce. The objectives of this paper are to assess the clinical risk factors of OL in a representative sample of the US population. Data from the oral mucosal tissue assessment and some other covariates of 15,811 participants in the US National Health and Nutrition Examination Survey (NHANES III) were included. The clinical definition of OL was applied according to the WHO criteria. Tobacco smoking was found as the strongest independent risk factor. The OR were 3.00 (0.77-11.8) for < or =10 cigarettes/day up to 6.01 (2.4-15.0) for >20 cigarettes/day. Diabetes, age and socio-economic status were found as independent predictors of OL. Alcohol consumption, race/ethnicity, years of education and BMI showed no independent association with OL. Females with a history of estrogen use were less likely to have OL with an OR of 0.34 (0.11-1.07). In conclusion, the role of diabetes and estrogen in the pathogenesis of OL should be further investigated.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Diabetes Complications, Female, Health Surveys, Humans, Leukoplakia, Oral/etiology, Logistic Models, Male, Middle Aged, Risk Factors, Smoking/adverse effects, Social Class",
author = "Thomas Dietrich and Reichart, {Peter A} and Christian Scheifele",
year = "2004",
month = feb,
day = "1",
doi = "10.1016/s1368-8375(03)00145-3",
language = "English",
volume = "40",
pages = "158--63",
journal = "ORAL ONCOL",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "2",

}

RIS

TY - JOUR

T1 - Clinical risk factors of oral leukoplakia in a representative sample of the US population

AU - Dietrich, Thomas

AU - Reichart, Peter A

AU - Scheifele, Christian

PY - 2004/2/1

Y1 - 2004/2/1

N2 - Studies on the risk factors of oral leukoplakia (OL) are relatively scarce. The objectives of this paper are to assess the clinical risk factors of OL in a representative sample of the US population. Data from the oral mucosal tissue assessment and some other covariates of 15,811 participants in the US National Health and Nutrition Examination Survey (NHANES III) were included. The clinical definition of OL was applied according to the WHO criteria. Tobacco smoking was found as the strongest independent risk factor. The OR were 3.00 (0.77-11.8) for < or =10 cigarettes/day up to 6.01 (2.4-15.0) for >20 cigarettes/day. Diabetes, age and socio-economic status were found as independent predictors of OL. Alcohol consumption, race/ethnicity, years of education and BMI showed no independent association with OL. Females with a history of estrogen use were less likely to have OL with an OR of 0.34 (0.11-1.07). In conclusion, the role of diabetes and estrogen in the pathogenesis of OL should be further investigated.

AB - Studies on the risk factors of oral leukoplakia (OL) are relatively scarce. The objectives of this paper are to assess the clinical risk factors of OL in a representative sample of the US population. Data from the oral mucosal tissue assessment and some other covariates of 15,811 participants in the US National Health and Nutrition Examination Survey (NHANES III) were included. The clinical definition of OL was applied according to the WHO criteria. Tobacco smoking was found as the strongest independent risk factor. The OR were 3.00 (0.77-11.8) for < or =10 cigarettes/day up to 6.01 (2.4-15.0) for >20 cigarettes/day. Diabetes, age and socio-economic status were found as independent predictors of OL. Alcohol consumption, race/ethnicity, years of education and BMI showed no independent association with OL. Females with a history of estrogen use were less likely to have OL with an OR of 0.34 (0.11-1.07). In conclusion, the role of diabetes and estrogen in the pathogenesis of OL should be further investigated.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Diabetes Complications

KW - Female

KW - Health Surveys

KW - Humans

KW - Leukoplakia, Oral/etiology

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Smoking/adverse effects

KW - Social Class

U2 - 10.1016/s1368-8375(03)00145-3

DO - 10.1016/s1368-8375(03)00145-3

M3 - SCORING: Journal article

C2 - 14693239

VL - 40

SP - 158

EP - 163

JO - ORAL ONCOL

JF - ORAL ONCOL

SN - 1368-8375

IS - 2

ER -