Clinical risk factors of oral leukoplakia in a representative sample of the US population
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Clinical risk factors of oral leukoplakia in a representative sample of the US population. / Dietrich, Thomas; Reichart, Peter A; Scheifele, Christian.
in: ORAL ONCOL, Jahrgang 40, Nr. 2, 01.02.2004, S. 158-63.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Clinical risk factors of oral leukoplakia in a representative sample of the US population
AU - Dietrich, Thomas
AU - Reichart, Peter A
AU - Scheifele, Christian
PY - 2004/2/1
Y1 - 2004/2/1
N2 - Studies on the risk factors of oral leukoplakia (OL) are relatively scarce. The objectives of this paper are to assess the clinical risk factors of OL in a representative sample of the US population. Data from the oral mucosal tissue assessment and some other covariates of 15,811 participants in the US National Health and Nutrition Examination Survey (NHANES III) were included. The clinical definition of OL was applied according to the WHO criteria. Tobacco smoking was found as the strongest independent risk factor. The OR were 3.00 (0.77-11.8) for < or =10 cigarettes/day up to 6.01 (2.4-15.0) for >20 cigarettes/day. Diabetes, age and socio-economic status were found as independent predictors of OL. Alcohol consumption, race/ethnicity, years of education and BMI showed no independent association with OL. Females with a history of estrogen use were less likely to have OL with an OR of 0.34 (0.11-1.07). In conclusion, the role of diabetes and estrogen in the pathogenesis of OL should be further investigated.
AB - Studies on the risk factors of oral leukoplakia (OL) are relatively scarce. The objectives of this paper are to assess the clinical risk factors of OL in a representative sample of the US population. Data from the oral mucosal tissue assessment and some other covariates of 15,811 participants in the US National Health and Nutrition Examination Survey (NHANES III) were included. The clinical definition of OL was applied according to the WHO criteria. Tobacco smoking was found as the strongest independent risk factor. The OR were 3.00 (0.77-11.8) for < or =10 cigarettes/day up to 6.01 (2.4-15.0) for >20 cigarettes/day. Diabetes, age and socio-economic status were found as independent predictors of OL. Alcohol consumption, race/ethnicity, years of education and BMI showed no independent association with OL. Females with a history of estrogen use were less likely to have OL with an OR of 0.34 (0.11-1.07). In conclusion, the role of diabetes and estrogen in the pathogenesis of OL should be further investigated.
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Diabetes Complications
KW - Female
KW - Health Surveys
KW - Humans
KW - Leukoplakia, Oral/etiology
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Risk Factors
KW - Smoking/adverse effects
KW - Social Class
U2 - 10.1016/s1368-8375(03)00145-3
DO - 10.1016/s1368-8375(03)00145-3
M3 - SCORING: Journal article
C2 - 14693239
VL - 40
SP - 158
EP - 163
JO - ORAL ONCOL
JF - ORAL ONCOL
SN - 1368-8375
IS - 2
ER -