Claudication, in contrast to angina pectoris, independently predicts mortality risk in the general population
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Claudication, in contrast to angina pectoris, independently predicts mortality risk in the general population. / Kieback, Arne G; Lorbeer, Roberto; Wallaschofski, Henri; Ittermann, Till; Völzke, Henry; Felix, Stephan; Dörr, Marcus.
In: VASA, Vol. 41, No. 2, 03.2012, p. 105-113.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Claudication, in contrast to angina pectoris, independently predicts mortality risk in the general population
AU - Kieback, Arne G
AU - Lorbeer, Roberto
AU - Wallaschofski, Henri
AU - Ittermann, Till
AU - Völzke, Henry
AU - Felix, Stephan
AU - Dörr, Marcus
PY - 2012/3
Y1 - 2012/3
N2 - BACKGROUND: The aim of our analyses was to investigate whether claudication and angina pectoris, each defined and based on the answer to a single question, are predictive of future mortality.PROBANDS AND METHODS: The study population consisted of 3995 subjects selected from the population-based Study of Health In Pomerania (SHIP). Kaplan-Meier analysis and multivariable Cox proportional hazards regression analysis were used to analyze the association of angina pectoris and claudication with all-cause and cardiovascular mortality adjusted for major cardiovascular risk factors.RESULTS: At baseline, 417 individuals had symptoms of angina pectoris, and 323 had symptoms of claudication. During a median follow-up of 8.5 years, 277 individuals died. Individuals with claudication had a higher fully-adjusted all-cause mortality rate (Hazard Ratio (HR) 1.79; 95 % CI 1.34, 2.39, p < 0.001) and a higher sex- and age-adjusted cardiovascular mortality rate (HR 1.76; 95 % CI 1.03, 2.99, p = 0.038) compared to subjects without claudication. In contrast, subjects with angina pectoris had neither an elevated fully-adjusted all-cause mortality rate (HR 1.15; 95 % CI 0.82, 1.61, p = 0.413) nor sex- and age-adjusted cardiovascular mortality rate (HR 0.71; 95 % CI 0.34, 1.48, p = 0.363) compared to those without this symptom.CONCLUSIONS: Claudication, in contrast to angina pectoris, is a strong, independent predictor of all-cause mortality.
AB - BACKGROUND: The aim of our analyses was to investigate whether claudication and angina pectoris, each defined and based on the answer to a single question, are predictive of future mortality.PROBANDS AND METHODS: The study population consisted of 3995 subjects selected from the population-based Study of Health In Pomerania (SHIP). Kaplan-Meier analysis and multivariable Cox proportional hazards regression analysis were used to analyze the association of angina pectoris and claudication with all-cause and cardiovascular mortality adjusted for major cardiovascular risk factors.RESULTS: At baseline, 417 individuals had symptoms of angina pectoris, and 323 had symptoms of claudication. During a median follow-up of 8.5 years, 277 individuals died. Individuals with claudication had a higher fully-adjusted all-cause mortality rate (Hazard Ratio (HR) 1.79; 95 % CI 1.34, 2.39, p < 0.001) and a higher sex- and age-adjusted cardiovascular mortality rate (HR 1.76; 95 % CI 1.03, 2.99, p = 0.038) compared to subjects without claudication. In contrast, subjects with angina pectoris had neither an elevated fully-adjusted all-cause mortality rate (HR 1.15; 95 % CI 0.82, 1.61, p = 0.413) nor sex- and age-adjusted cardiovascular mortality rate (HR 0.71; 95 % CI 0.34, 1.48, p = 0.363) compared to those without this symptom.CONCLUSIONS: Claudication, in contrast to angina pectoris, is a strong, independent predictor of all-cause mortality.
KW - Adult
KW - Aged
KW - Angina Pectoris/mortality
KW - Female
KW - Germany/epidemiology
KW - Health Surveys
KW - Humans
KW - Intermittent Claudication/mortality
KW - Kaplan-Meier Estimate
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Prognosis
KW - Proportional Hazards Models
KW - Risk Assessment
KW - Risk Factors
KW - Surveys and Questionnaires
KW - Time Factors
U2 - 10.1024/0301-1526/a000172
DO - 10.1024/0301-1526/a000172
M3 - SCORING: Journal article
C2 - 22403128
VL - 41
SP - 105
EP - 113
JO - VASA
JF - VASA
SN - 0301-1526
IS - 2
ER -